Sol–Gel‐Based Advanced Porous Silica Materials for Biomedical Applications

Lei, Qi; Guo, Jimin; Noureddine, Achraf; Wang, Aixia; Wuttke, Stefan; Brinker, C. Jeffrey; Zhu, Wei

doi:10.1002/adfm.201909539

Sol–Gel‐Based Advanced Porous Silica Materials for Biomedical Applications

Journal Article · Thu Apr 02 00:00:00 EDT 2020 · Advanced Functional Materials

DOI:https://doi.org/10.1002/adfm.201909539· OSTI ID:1608069

Lei, Qi ^[1]; Guo, Jimin ^[2]; Noureddine, Achraf ^[3]; Wang, Aixia ^[1]; Wuttke, Stefan ^[4]; ^[3]; Zhu, Wei ^[1]

MOE International Joint Research Laboratory on Synthetic Biology and Medicines School of Biology and Biological Engineering South China University of Technology Guangzhou 510006 P. R. China
Center for Micro‐Engineered Materials Department of Chemical and Biological Engineering the University of New Mexico Albuquerque NM 87131 USA, Department of Internal Medicine, Molecular Medicine the University of New Mexico Albuquerque NM 87131 USA
Center for Micro‐Engineered Materials Department of Chemical and Biological Engineering the University of New Mexico Albuquerque NM 87131 USA
BCMaterials Basque Center for Materials UPV/EHU Science Park Leioa 48940 Spain, Ikerbasque Basque Foundation for Science Bilbao 48013 Spain

Abstract

Porous silica‐based materials have burgeoning applications ranging from fillers and additives, to adsorbents, catalysts, and recently therapeutic agents and vaccines in nanomedicine. The preponderance of these materials is made by sol–gel processing wherein soluble silica precursors are reacted to form amorphous networks composed of siloxane bonds. The facile sol–gel approach allows for an unlimited variety of binary tertiary and more complex chemical compositions including organic ligands and networks resulting in so‐called organic–inorganic hybrid materials. Here, a brief review of the recent progress in sol–gel‐derived silica materials prepared as particles, thin films, biosilica/silica bioreplicas (of molecules, cells and organisms), and their related preparation, properties, and bioapplications is provided. First, it highlights the recent achievements of mesoporous silica nanoparticles in biomedical applications, including therapeutic agent delivery, multimodal imaging and theranostics, and bone tissue engineering and repair. Second, the research in evaporation‐induced self‐assembly (EISA)‐based mesostructured silica thin films and cell‐directed EISA in bio/nano interfaces for various bioapplications, such as bioactive coatings, biosensing, and living cell immobilization, has been reviewed. Third, the pioneering work in biomimetic silicification/immobilization of biomolecules and bio‐organisms and silica bioreplication of complex bio‐organisms is summarized. Finally, it is concluded with personal perspectives on the directions of future work on this field.

View Accepted Manuscript (Publisher)

Sponsoring Organization:: USDOE

OSTI ID:: 1608069

Journal Information:: Advanced Functional Materials, Journal Name: Advanced Functional Materials Journal Issue: 41 Vol. 30; ISSN 1616-301X

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

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Templating of Mesoporous Molecular Sieves by Nonionic Polyethylene Oxide Surfactants Bagshaw, S. A.; Prouzet, E.; Pinnavaia, T. J. Science, Vol. 269, Issue 5228 https://doi.org/10.1126/science.269.5228.1242	journal	September 1995
Triblock Copolymer Syntheses of Mesoporous Silica with Periodic 50 to 300 Angstrom Pores Zhao, Dongyuan; Feng, Jianglin; Huo, Qisheng Science, Vol. 279, Issue 5350, p. 548-552 https://doi.org/10.1126/science.279.5350.548	journal	January 1998
Polycationic Peptides from Diatom Biosilica That Direct Silica Nanosphere Formation Kröger, Nils; Deutzmann, Rainer; Sumper, Manfred Science, Vol. 286, Issue 5442, p. 1129-1132 https://doi.org/10.1126/science.286.5442.1129	journal	November 1999
Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe Phillips, E.; Penate-Medina, O.; Zanzonico, P. B. Science Translational Medicine, Vol. 6, Issue 260 https://doi.org/10.1126/scitranslmed.3009524	journal	October 2014
Live Diatom Silica Immobilization of Multimeric and Redox-Active Enzymes Sheppard, V. C.; Scheffel, A.; Poulsen, N. Applied and Environmental Microbiology, Vol. 78, Issue 1 https://doi.org/10.1128/AEM.06698-11	journal	November 2011
Unique Biological Degradation Behavior of Stöber Mesoporous Silica Nanoparticles from Their Interiors to Their Exteriors Chen, Guotao; Teng, Zhaogang; Su, Xiaodan Journal of Biomedical Nanotechnology, Vol. 11, Issue 4 https://doi.org/10.1166/jbn.2015.2072	journal	April 2015
The Preparation of Alkyltriinethylaininonium–Kaneinite Complexes and Their Conversion to Microporous Materials Yanagisawa, Tsuneo; Shimizu, Toshio; Kuroda, Kazuyuki Bulletin of the Chemical Society of Japan, Vol. 63, Issue 4 https://doi.org/10.1246/bcsj.63.988	journal	April 1990
FRET Imaging of Diatoms Expressing a Biosilica-Localized Ribose Sensor Marshall, Kathryn E.; Robinson, Errol W.; Hengel, Shawna M. PLoS ONE, Vol. 7, Issue 3 https://doi.org/10.1371/journal.pone.0033771	journal	March 2012
Nanoporous silica coatings on implant surfaces: characterization, stability, biocompatibility and drug release properties Ehlert, Nina; Lüßenhop, Tammo; Krueger, Ilka BioNanoMaterials, Vol. 14, Issue 1-2 https://doi.org/10.1515/bnm-2012-1001	journal	January 2013
Evaporation-Induced Self-Assembly: Functional Nanostructures Made Easy Brinker, C. Jeffrey MRS Bulletin, Vol. 29, Issue 9 https://doi.org/10.1557/mrs2004.183	journal	September 2004
Silaffins in Silica Biomineralization and Biomimetic Silica Precipitation Lechner, Carolin; Becker, Christian Marine Drugs, Vol. 13, Issue 8 https://doi.org/10.3390/md13085297	journal	August 2015
Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances Narayan, Reema; Nayak, Usha; Raichur, Ashok Pharmaceutics, Vol. 10, Issue 3 https://doi.org/10.3390/pharmaceutics10030118	journal	August 2018

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