Identification of circadian rhythms in Nannochloropsis species using bioluminescence reporter lines

Poliner, Eric; Cummings, Cameron; Newton, Linsey; Farré, Eva M.

doi:10.1111/tpj.14314

Identification of circadian rhythms in Nannochloropsis species using bioluminescence reporter lines

Journal Article · Fri Apr 19 00:00:00 EDT 2019 · The Plant Journal

DOI:https://doi.org/10.1111/tpj.14314· OSTI ID:1603781

Poliner, Eric ^[1]; Cummings, Cameron ^[2]; Newton, Linsey ^[2]; ^[2]

Michigan State Univ., East Lansing, MI (United States); MSU Plant Biology Department
Michigan State Univ., East Lansing, MI (United States)

Circadian clocks allow organisms to predict environmental changes caused by the rotation of the Earth. Although circadian rhythms are widespread among different taxa, the core components of circadian oscillators are not conserved and differ between bacteria, plants, animals and fungi. Stramenopiles are a large group of organisms in which circadian rhythms have been only poorly characterized and no clock components have been identified. In this work, we have investigated cell division and molecular rhythms in Nannochloropsis species. In the four strains tested, cell division occurred principally during the night period under diel conditions; however, these rhythms damped within 2–3 days after transfer to constant light. We developed firefly luciferase reporters for the long-term monitoring of in vivo transcriptional rhythms in two Nannochlropsis species, Nannochloropsis oceanica CCMP1779 and Nannochloropsis salina CCMP537. The reporter lines express anticipatory behavior under light/dark cycles and free-running bioluminescence rhythms with periods of ~21–31 h that damped within ~3–4 days under constant light. Using different entrainment regimes, we demonstrate that these rhythms are modulated by a circadian-type oscillator. In addition, the phase of free-running luminescence rhythms can be modulated pharmacologically using a CK1 ε/δ inhibitor, suggesting a role of this kinase in the Nannochloropsis clock. Finally, together with the molecular and genomic tools available for Nannochloropsis species, these reporter lines represent an excellent system for future studies on the molecular mechanisms of stramenopile circadian oscillators.

View Accepted Manuscript (DOE)

Research Organization:: Michigan State Univ., East Lansing, MI (United States)

Sponsoring Organization:: National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

Grant/Contract Number:: FG02-91ER20021

OSTI ID:: 1603781

Journal Information:: The Plant Journal, Journal Name: The Plant Journal Journal Issue: 1 Vol. 99; ISSN 0960-7412

Publisher:: Society for Experimental BiologyCopyright Statement

Country of Publication:: United States

Language:: English

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54 ENVIRONMENTAL SCIENCES
59 BASIC BIOLOGICAL SCIENCES
Nannochloropsis genus
Nannochloropsis oceanica
Nannochloropsis salina
bioluminescence reporter
cell division
circadian rhythms
luciferase
stramenopiles
transcription

Identification of circadian rhythms in Nannochloropsis species using bioluminescence reporter lines

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