Nanoconfinement Effects on Redox Probe Transport in Lipid Assemblies on and in Mesoporous Silica Thin Films

Zhou, Shanshan; Guilfoil, Emma; He, Yuxin; Nagpure, Suraj; Islam, Syed Z.; Khan, M. Arif; Rankin, Stephen E.; Knutson, Barbara L.

doi:10.1002/admi.201901787

Nanoconfinement Effects on Redox Probe Transport in Lipid Assemblies on and in Mesoporous Silica Thin Films

Journal Article · Thu Feb 13 23:00:00 EST 2020 · Advanced Materials Interfaces

DOI:https://doi.org/10.1002/admi.201901787· OSTI ID:1599655

Zhou, Shanshan ^[1]; Guilfoil, Emma ^[1]; He, Yuxin ^[1]; Nagpure, Suraj ^[1]; Islam, Syed Z. ^[1]; Khan, M. Arif ^[1]; ^[1]; ^[1]

Department of Chemical and Materials Engineering University of Kentucky 177 F.P. Anderson Tower Lexington KY 40506‐0046 USA

Abstract

Redox probe transport through supported lipid bilayers and nanopore‐confined lipid assemblies on silica thin films is examined using electrochemical impedance spectroscopy (EIS). These supported lipid systems are emerging biomimetic separation and sensor platforms. The ability to quantify the accessibility of the pore structure of the mesoporous silica thin films is demonstrated, which is essential for the incorporation of carriers into the lipids for selective solute transport. Redox probe molecules with varying hydrophilicity are used to compare ion transport in supported lipid pore‐spanning bilayers (enveloped bilayers) and novel lipid filled pores of mesoporous silica thin films. The films feature orthogonally oriented 8–10 nm cylindrical nanopores formed by deposition of P123‐templated silica sols onto chemically modified fluorine‐doped tin oxide. Nanopore accessibility is confirmed by EIS with hydrophilic probe 1,1′‐ferrocenedimethanol (FDM). Filling the pores with lipid 1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphocholine results in a superior barrier (with roughly 1/9 the permeability) to transport of FDM compared to fragile enveloped lipid bilayers deposited by vesicle fusion. The pore‐confined lipids not only provide a better barrier to FDM, but also a better pathway for the transport across the films of a hydrophobic redox probe 1,1′‐dioctadecyl‐4,4′‐bipyridinium dibromide, with an ideal transport selectivity of 11 compared to FDM.

View Accepted Manuscript (Publisher)

Sponsoring Organization:: USDOE

Grant/Contract Number:: NONE; AC02-06CH11357

OSTI ID:: 1599655

Alternate ID(s):: OSTI ID: 1616613

Journal Information:: Advanced Materials Interfaces, Journal Name: Advanced Materials Interfaces Journal Issue: 7 Vol. 7; ISSN 2196-7350

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

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