Optical Biosensors Based on Photonic Crystals Supporting Bound States in the Continuum

Romano, Silvia; Lamberti, Annalisa; Masullo, Mariorosario; Penzo, Erika; Cabrini, Stefano; Rendina, Ivo; Mocella, Vito

doi:10.3390/ma11040526

Title: Optical Biosensors Based on Photonic Crystals Supporting Bound States in the Continuum

Journal Article · Fri Mar 30 00:00:00 EDT 2018 · Materials

DOI:https://doi.org/10.3390/ma11040526· OSTI ID:1596670

Romano, Silvia ^[1]; Lamberti, Annalisa ^[2];

^[3]; Penzo, Erika ^[4]; Cabrini, Stefano ^[4]; Rendina, Ivo ^[1]; Mocella, Vito ^[1]

National Council of Research, Naples (Italy). Inst. for Microelectronics and Microsystems
Univ. of Naples Federico II (Italy)
Univ. of Naples, Napoli (Italy)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

A novel optical label-free bio-sensing platform based on a new class of resonances supported in a photonic crystal metasurface is reported herein. Molecular binding is detected as a shift in the resonant wavelength of the bound states in the continuum of radiation modes. The new configuration is applied to the recognition of the interaction between protein p53 and its protein regulatory partner murine double minute 2 (MDM2). A detection limit of 66 nM for the protein p53 is found. The device provides an excellent interrogation stability and loss-free operation, requires minimal optical interrogation equipment and can be easily optimized to work in a wide wavelength range.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1596670

Journal Information:: Materials, Vol. 11, Issue 4; ISSN 1996-1944

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 64 works

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