Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia

Journal Article · · Cancer Cell

Not Available

Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER); USDOE Office of Science (SC), Basic Energy Sciences (BES); Leukemia & Lymphoma Society; National Institutes of Health (NIH)
Grant/Contract Number:
SC0012704; AC02-76SF00515
OSTI ID:
1595501
Alternate ID(s):
OSTI ID: 1570747
OSTI ID: 1783959
Journal Information:
Cancer Cell, Journal Name: Cancer Cell Journal Issue: 1 Vol. 34; ISSN 1535-6108
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

References (56)

UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
Web servers and services for electrostatics calculations with APBS and PDB2PQR journal February 2011
The Bifunctional Cytosolic 5′-Nucleotidase: Regulation of the Phosphotransferase and Nucleotidase Activities journal July 1994
Computer Analysis of Bacterial Haloacid Dehalogenases Defines a Large Superfamily of Hydrolases with Diverse Specificity journal November 1994
XtalView/Xfit—A Versatile Program for Manipulating Atomic Coordinates and Electron Density journal April 1999
Nucleoside phosphotransferase activity of human colon carcinoma cytosolic 5′-nucleotidase journal November 1991
5′-nucleotidase of chicken liver journal September 1967
Diadenosine tetraphosphate activates cytosol 5′-nucleotidase journal July 1986
The phosphotransferase activity of cytosolic 5′-nucleotidase; a purine analog phosphorylating enzyme journal June 1996
High Km soluble 5′-nucleotidase from human placenta. Properties and allosteric regulation by IMP and ATP. journal December 1988
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Role of 5′-nucleotidase in thiopurine metabolism: Enzyme kinetic profile and association with thio-GMP levels in patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment journal November 2005
Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5′-Nucleotidase II journal May 2011
The 5′-nucleotidases as regulators of nucleotide and drug metabolism journal July 2005
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain journal May 1998
Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia journal February 2017
Super-resolution biomolecular crystallography with low-resolution data journal April 2010
Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations journal May 2015
Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia journal January 2018
Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing journal June 2014
Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia journal March 2015
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia journal February 2013
The Cancer Genome Atlas Pan-Cancer analysis project journal September 2013
Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas journal January 2014
Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL journal February 2013
A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia journal September 2014
Negative feedback–defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL journal May 2015
Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia journal September 2015
I-TASSER: a unified platform for automated protein structure and function prediction journal March 2010
Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation journal February 2018
Bovine cytosolic IMP/GMP-specific 5′-nucleotidase: cloning and expression of active enzyme in Escherichia coli journal December 1997
IMP-GMP 5′-Nucleotidase from Rat Brain: Activation by Polyphosphates journal September 1998
Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia journal September 2016
A New Class of Phosphotransferases Phosphorylated on an Aspartate Residue in an Amino-terminal DXDX(T/V) Motif journal June 1998
Bovine Cytosolic 5′-Nucleotidase Acts through the Formation of an Aspartate 52-Phosphoenzyme Intermediate journal September 2001
Crystal Structure of Human Cytosolic 5′-Nucleotidase II journal June 2007
Fast and accurate short read alignment with Burrows-Wheeler transform journal May 2009
OncodriveCLUST: exploiting the positional clustering of somatic mutations to identify cancer genes journal July 2013
Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc journal February 1999
The PredictProtein server journal July 2004
Dali server update journal April 2016
COMO : a program for combined molecular replacement journal July 2001
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Modeling of loops in protein structures journal January 2000
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia journal October 2004
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells journal December 2013
Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders journal January 2014
The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants journal July 1997
Therapeutic targeting of HES1 transcriptional programs in T-ALL journal April 2015
SAVI: a statistical algorithm for variant frequency identification journal January 2013
Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia journal October 2016
3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets journal January 2017
Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool journal January 2017
Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis journal February 2017
Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation journal August 2015
A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w journal April 2012

Similar Records

Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia
Journal Article · Fri Dec 31 23:00:00 EST 2021 · Cancer Cell · OSTI ID:1783959

Outcome following late marrow relapse in childhood acute lymphoblastic leukemia
Journal Article · Mon Oct 01 00:00:00 EDT 1984 · J. Clin. Oncol.; (United States) · OSTI ID:5615300

Related Subjects