Engineering of Saccharomyces cerevisiae for efficient fermentation of cellulose

Oh, Eun Joong; Jin, Yong-Su

doi:10.1093/femsyr/foz089

Engineering of Saccharomyces cerevisiae for efficient fermentation of cellulose

Journal Article · Thu Jan 09 00:00:00 EST 2020 · FEMS Yeast Research

DOI:https://doi.org/10.1093/femsyr/foz089· OSTI ID:1592780

Oh, Eun Joong ^[1]; ^[2]

Univ. of Colorado, Boulder, CO (United States); Renewable and Sustainable Energy Inst. (RASEI), Boulder, CO (United States)
Univ. of Illinois at Urbana-Champaign, IL (United States). Dept. of Food Science and Human Nutrition; Univ. of Illinois at Urbana-Champaign, IL (United States). Carl R. Woese Inst. for Genomic Biology; Center for Advanced Bioenergy and Bioproducts Innovation (CABBI), Urbana, IL (United States)

ABSTRACT

Conversion of lignocellulosic biomass to biofuels using microbial fermentation is a promising option to substitute petroleum-based production economically and sustainably. The substantial efforts to design yeast strains for biomass hydrolysis have led to industrially applicable biological routes. Saccharomyces cerevisiae is a robust microbial platform widely used in biofuel production, based on its amenability to systems and synthetic biology tools. The vital challenges for the efficient microbial conversion of lignocellulosic biomass by engineered S. cerevisiae include heterologous expression of cellulolytic enzymes, co-fermentation of hexose and pentose sugars, and robustness against various stresses. Scientists developed many engineering strategies for cellulolytic S. cerevisiae strains, bringing the application of consolidated bioprocess at an industrial scale. Recent advances in the development and implementation of engineered yeast strains capable of assimilating lignocellulose will be reviewed.

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Research Organization:: Center for Advanced Bioenergy and Bioproducts Innovation (CABBI), Urbana, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)

Grant/Contract Number:: SC0018420

OSTI ID:: 1592780

Alternate ID(s):: OSTI ID: 1595946

Journal Information:: FEMS Yeast Research, Journal Name: FEMS Yeast Research Journal Issue: 1 Vol. 20; ISSN 1567-1356

Country of Publication:: United States

Language:: English

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