Value-added biotransformation of cellulosic sugars by engineered Saccharomyces cerevisiae

Lane, Stephan; Dong, Jia; Jin, Yong -Su

doi:10.1016/j.biortech.2018.04.013

Value-added biotransformation of cellulosic sugars by engineered Saccharomyces cerevisiae

Journal Article · Sat Apr 07 00:00:00 EDT 2018 · Bioresource Technology

DOI:https://doi.org/10.1016/j.biortech.2018.04.013· OSTI ID:1489217

Lane, Stephan ^[1]; Dong, Jia ^[2]; Jin, Yong -Su ^[2]

Univ. of Illinois at Urbana-Champaign, Urbana, IL (United States); CABBI
Univ. of Illinois at Urbana-Champaign, Urbana, IL (United States)

The substantial research efforts into lignocellulosic biofuels have generated an abundance of valuable knowledge and technologies for metabolic engineering. In particular, these investments have led to a vast growth in proficiency of engineering the yeast Saccharomyces cerevisiae for consuming lignocellulosic sugars, enabling the simultaneous assimilation of multiple carbon sources, and producing a large variety of value-added products by introduction of heterologous metabolic pathways. While microbial conversion of cellulosic sugars into large-volume low-value biofuels is not currently economically feasible, there may still be opportunities to produce other value-added chemicals as regulation of cellulosic sugar metabolism is quite different from glucose metabolism. Furthermore, this review summarizes these recent advances with an emphasis on employing engineered yeast for the bioconversion of lignocellulosic sugars into a variety of non-ethanol value-added products.

View Accepted Manuscript (DOE)

Research Organization:: Center for Advanced Bioenergy and Bioproducts Innovation (CABBI), Urbana, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)

Grant/Contract Number:: SC0018420

OSTI ID:: 1489217

Alternate ID(s):: OSTI ID: 2396777
OSTI ID: 1991832

Journal Information:: Bioresource Technology, Journal Name: Bioresource Technology Journal Issue: C Vol. 260; ISSN 0960-8524

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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