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Influence of side-chain length on long-term release kinetics from poly(2-oxazoline)-drug conjugate networks

Journal Article · · European Polymer Journal
 [1];  [2];  [2];  [1];  [1];  [3];  [3];  [2];  [1]
  1. Queensland Univ. of Technology, Queensland (Australia). Inst. of Health and Biomedical Innovation, Science and Engineering Faculty
  2. Ghent Univ., Ghent (Belgium). Supramolecular Chemistry Group, Centre of Macromolecular Chemistry (CMaC), Dept. of Organic and Macromolecular Chemistry
  3. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Four drug-conjugated poly(2-alkyl-2-oxazoline) (PAOx) networks with different hydrophobicity were synthesized via copolymerization of either 2-methyl-, 2-ethyl-, 2-propyl- or 2-butyl-2-oxazoline with the functional monomer, 2-dec-9-enyl-2-oxazoline. The incorporation of a labile ester linkage between the polymer and the drug benazepril allowed for sustained drug release over periods of months with the release rates strongly depending on the hydrophobicity of the polymer pendant groups. Drug loading of 13 ± 2 wt% was used with 10 mol% crosslinking sites simply by tuning the thiol-ene stoichiometry. The networks exhibited negligible cell toxicity but cell repulsion was observed for hydrogels based on poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline) while those based on poly(2-n-propyl-2-oxazoline) and poly(2-n-butyl-2-oxaoline) showed cell adhesion. Furthermore, these results suggest that PAOx networks have great potential as drug delivery devices for long-lasting drug release applications.

Research Organization:
Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)
Sponsoring Organization:
USDOE National Nuclear Security Administration (NNSA)
Grant/Contract Number:
AC04-94AL85000
OSTI ID:
1574440
Alternate ID(s):
OSTI ID: 1775758
Report Number(s):
SAND--2019-12725J; 680588
Journal Information:
European Polymer Journal, Journal Name: European Polymer Journal Journal Issue: C Vol. 120; ISSN 0014-3057
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

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Acyl guanidine functional poly(2‐oxazoline)s as reactive intermediates and stimuli‐responsive materials journal November 2019

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