Development and Scale-up of Continuous Electrocatalytic Hydrogenation of Functionalized Nitro Arenes, Nitriles, and Unsaturated Aldehydes
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- GSK, Advanced Manufacturing Technologies, King of Prussia, PA (United States)
- GSK, Advanced Manufacturing Technologies, King of Prussia, PA (United States); Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- GSK, Advanced Manufacturing Technologies, King of Prussia, PA (United States); Univ. of Victoria, Victoria, BC (Canada)
- GSK, API Chemistry, Hertfordshire (United Kingdom)
Electrolysis flow reactors based on the filter-press architecture of redox flow batteries have proven to be effective and scalable toward the production of commercially relevant, pharmaceutical quantities of anilines (>500 kg/year) from halogen-, hydroxyl-, and carbonyl-substituted nitroarenes. Turbulent flow through the carbon felts on which the catalysts were supported facilitated scaling toward production levels because it conferred on the reactors scale-independent, plug flow-like residence time distributions and high mass transfer coefficients. Equipping the cells with microreference electrodes made it possible to transfer reaction conditions first developed in batch systems to the continuous flow reactors. In conclusion, the catalysts prepared by incipient wetness impregnation of metal salts into lightly oxidized carbon felt supports were readily generalizable.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- Grant/Contract Number:
- AC05-76RL01830
- OSTI ID:
- 1572942
- Report Number(s):
- PNNL-SA-123343
- Journal Information:
- Organic Process Research & Development, Vol. 23, Issue 9; ISSN 1083-6160
- Publisher:
- ACS PublicationsCopyright Statement
- Country of Publication:
- United States
- Language:
- English
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