Supramolecular strategies for protein immobilization and modification

Finbloom, Joel A.; Francis, Matthew B.

doi:10.1016/j.cbpa.2018.05.023

Supramolecular strategies for protein immobilization and modification

Journal Article · Sun Jul 21 00:00:00 EDT 2019 · Current Opinion in Chemical Biology

DOI:https://doi.org/10.1016/j.cbpa.2018.05.023· OSTI ID:1559158

Finbloom, Joel A. ^[1]; Francis, Matthew B. ^[2]

Univ. of California, Berkeley, CA (United States). Dept. of Chemistry
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Science Div.

Protein immobilization and modification are widely used techniques in the fields of chemical biology and biomaterials science. While covalent strategies based on small molecules are traditionally used, supramolecular chemistry offers numerous useful opportunities for guiding the modification locations on complex protein landscapes and introducing different degrees of reversibility into the products. In this opinion, we highlight recent advances in using supramolecular interactions, particularly host-guest chemistry, for controlling protein modification and immobilization. We discuss supramolecular strategies for protein-conjugate purification and capture, as well as for protein modification via host-guest interactions and metal coordination. Lastly, we address recent advances in utilizing supramolecular interactions to direct covalent protein modification. These examples of supramolecular chemical biology present opportunities to advance a wide range of applications, including proteomics and drug delivery.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1559158

Journal Information:: Current Opinion in Chemical Biology, Journal Name: Current Opinion in Chemical Biology Journal Issue: C Vol. 46; ISSN 1367-5931

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Supramolecular strategies for protein immobilization and modification

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