One-Pot Hydrothermal Synthesis of Elements (B, N, P)-Doped Fluorescent Carbon Dots for Cell Labelling, Differentiation and Outgrowth of Neuronal Cells

Kumar, Vijay B.; Kumar, Raj; Friedman, Ofir; Golan, Yuval; Gedanken, Aharon; Shefi, Orit

doi:10.1002/slct.201900581

Title: One-Pot Hydrothermal Synthesis of Elements (B, N, P)-Doped Fluorescent Carbon Dots for Cell Labelling, Differentiation and Outgrowth of Neuronal Cells

Journal Article · Thu Apr 11 00:00:00 EDT 2019 · Chemistry Select

DOI:https://doi.org/10.1002/slct.201900581· OSTI ID:1544748

^[1];

^[2]; Friedman, Ofir ^[3]; Golan, Yuval ^[3];

^[2]; Shefi, Orit ^[2]

Bar-Ilan Univ., Ramat Gan (Israel); Ben-Gurion Univ. of the Negev, Beer Sheva (Israel); Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Bar-Ilan Univ., Ramat Gan (Israel)
Ben-Gurion Univ. of the Negev, Beer Sheva (Israel)

The use of the chemically modified one-step facile hydrothermal process to develop Boron (B), Nitrogen (N), and Phosphorous (P) doped carbon dots (E@CDs) is reported on in this work. The chemical characterization of the E@CDs was systematically studied by several analytical techniques that confer doping of elements by known characteristics. The obtained E@CDs had observed very homogeneous size distribution and displayed excitation dependent fluorescence properties, and high quantum yield (QY) was measured in case of B and N doping. Excellent cell viability and good cellular uptake was observed for all E@CDs. Lastly, E@CDs were compared with pristine CDs on their effect on cell labelling, neural differentiation process and outgrowth of neurite network. By manipulating the doping of CDs, we can control the branching pattern and outgrowth of neuronal developments. The E@CDs are capable due to their photostability biocompatibility, and possible selective affinity towards nanomedicine applications.

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Research Organization:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 1544748

Report Number(s):: LA-UR-19-26191

Journal Information:: Chemistry Select, Vol. 4, Issue 14; ISSN 2365-6549

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 23 works

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References (46)

Evaluation of the photocatalytic activity of Ln3+–TiO2 nanomaterial using fluorescence technique for real wastewater treatment Saif, M.; Aboul-Fotouh, S. M. K.; El-Molla, S. A. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Vol. 128 https://doi.org/10.1016/j.saa.2014.02.031	journal	July 2014
From Molecular Design and Materials Construction to Organic Nanophotonic Devices Zhang, Chuang; Yan, Yongli; Zhao, Yong Sheng Accounts of Chemical Research, Vol. 47, Issue 12 https://doi.org/10.1021/ar500192v	journal	October 2014
Fluorescent PLLA-nanodiamond composites for bone tissue engineering Zhang, Qingwei; Mochalin, Vadym N.; Neitzel, Ioannis Biomaterials, Vol. 32, Issue 1 https://doi.org/10.1016/j.biomaterials.2010.08.090	journal	January 2011
Novel fluorescent carbonic nanomaterials for sensing and imaging Demchenko, Alexander P.; Dekaliuk, Mariia O. Methods and Applications in Fluorescence, Vol. 1, Issue 4 https://doi.org/10.1088/2050-6120/1/4/042001	journal	August 2013
Prolonged controlled delivery of nerve growth factor using porous silicon nanostructures Zilony, Neta; Rosenberg, Michal; Holtzman, Liran Journal of Controlled Release, Vol. 257 https://doi.org/10.1016/j.jconrel.2016.12.008	journal	July 2017
A hydrothermal reaction of an aqueous solution of BSA yields highly fluorescent N doped C-dots used for imaging of live mammalian cells Kumar, Vijay Bhooshan; Sheinberger, Jonathan; Porat, Zeev Journal of Materials Chemistry B, Vol. 4, Issue 17 https://doi.org/10.1039/C6TB00519E	journal	January 2016
A review of carbon dots in biological applications Wang, Jilong; Qiu, Jingjing Journal of Materials Science, Vol. 51, Issue 10 https://doi.org/10.1007/s10853-016-9797-7	journal	February 2016
Amine-functionalized, porous silica-coated NaYF4:Yb/Er upconversion nanophosphors for efficient delivery of doxorubicin and curcumin Reddy, Kumbam Lingeshwar; Sharma, Peeyush Kumar; Singh, Ashutosh Materials Science and Engineering: C, Vol. 96 https://doi.org/10.1016/j.msec.2018.11.007	journal	March 2019
Fluorescent Nanoparticles with Tissue-Dependent Affinity for Live Zebrafish Imaging Khajuria, Deepak Kumar; Kumar, Vijay Bhooshan; Karasik, David ACS Applied Materials & Interfaces, Vol. 9, Issue 22 https://doi.org/10.1021/acsami.7b04668	journal	May 2017
Carbon-Dot-Based Ratiometric Fluorescent Probe for Imaging and Biosensing of Superoxide Anion in Live Cells Gao, Xiang; Ding, Changqin; Zhu, Anwei Analytical Chemistry, Vol. 86, Issue 14 https://doi.org/10.1021/ac501499y	journal	June 2014
Solid lipid nanoparticles for the controlled delivery of poorly water soluble non-steroidal anti-inflammatory drugs Kumar, Raj; Singh, Ashutosh; Garg, Neha Ultrasonics Sonochemistry, Vol. 40 https://doi.org/10.1016/j.ultsonch.2017.08.018	journal	January 2018
Toxicity of carbon dots – Effect of surface functionalization on the cell viability, reactive oxygen species generation and cell cycle Havrdova, Marketa; Hola, Katerina; Skopalik, Josef Carbon, Vol. 99 https://doi.org/10.1016/j.carbon.2015.12.027	journal	April 2016
Progress of Carbon Quantum Dots in Photocatalysis Applications Zhang, Zhijie; Zheng, Tingting; Li, Xiaoming Particle & Particle Systems Characterization, Vol. 33, Issue 8 https://doi.org/10.1002/ppsc.201500243	journal	April 2016
High catalytic activities of palladium nanowires synthesized using liquid crystal templating approach Chawla, Mohit; Kumar, Raj; Siril, Prem Felix Journal of Molecular Catalysis A: Chemical, Vol. 423 https://doi.org/10.1016/j.molcata.2016.06.014	journal	November 2016
Ultrafine Highly Magnetic Fluorescent γ-Fe ₂ O ₃ /NCD Nanocomposites for Neuronal Manipulations Kumar, Vijay Bhooshan; Marcus, Michal; Porat, Ze’ev ACS Omega, Vol. 3, Issue 2 https://doi.org/10.1021/acsomega.7b01666	journal	February 2018
Non-metal single/dual doped carbon quantum dots: a general flame synthetic method and electro-catalytic properties Han, Yuzhi; Tang, Di; Yang, Yanmei Nanoscale, Vol. 7, Issue 14 https://doi.org/10.1039/C4NR07116F	journal	January 2015
Activated Carbon Modified with Carbon Nanodots as Novel Electrode Material for Supercapacitors Kumar, Vijay Bhooshan; Borenstein, Arie; Markovsky, Boris The Journal of Physical Chemistry C, Vol. 120, Issue 25 https://doi.org/10.1021/acs.jpcc.6b04045	journal	June 2016
Refractive-Index Tuning of Highly Fluorescent Carbon Dots Kumar, Vijay Bhooshan; Sahu, Amit Kumar; Mohsin, Abu S. M. ACS Applied Materials & Interfaces, Vol. 9, Issue 34 https://doi.org/10.1021/acsami.7b08985	journal	August 2017
Chemiluminescence behavior of the carbon dots and the reduced state carbon dots Teng, Ping; Xie, Jianxin; Long, Yijuan Journal of Luminescence, Vol. 146 https://doi.org/10.1016/j.jlumin.2013.09.036	journal	February 2014
Carbon nanomaterials: multi-functional agents for biomedical fluorescence and Raman imaging Bartelmess, J.; Quinn, S. J.; Giordani, S. Chemical Society Reviews, Vol. 44, Issue 14 https://doi.org/10.1039/C4CS00306C	journal	January 2015
Luminescent nanomaterials for biological labelling Wang, Feng; Tan, Wee Beng; Zhang, Yong Nanotechnology, Vol. 17, Issue 1 https://doi.org/10.1088/0957-4484/17/1/R01	journal	November 2005
Strong Two-Photon-Induced Fluorescence from Photostable, Biocompatible Nitrogen-Doped Graphene Quantum Dots for Cellular and Deep-Tissue Imaging Liu, Qian; Guo, Beidou; Rao, Ziyu Nano Letters, Vol. 13, Issue 6 https://doi.org/10.1021/nl400368v	journal	May 2013
Recent applications of carbon nanomaterials in fluorescence biosensing and bioimaging Wen, Jia; Xu, Yongqian; Li, Hongjuan Chemical Communications, Vol. 51, Issue 57 https://doi.org/10.1039/C5CC02887F	journal	January 2015
Hydrothermal synthesis of nitrogen and boron doped carbon quantum dots with yellow-green emission for sensing Cr( vi ), anti-counterfeiting and cell imaging Guo, Yongming; Chen, Yuzhi; Cao, Fengpu RSC Adv., Vol. 7, Issue 76 https://doi.org/10.1039/C7RA09785A	journal	January 2017
Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots Lovrić, Jasmina; Bazzi, Hassan S.; Cuie, Yan Journal of Molecular Medicine, Vol. 83, Issue 5 https://doi.org/10.1007/s00109-004-0629-x	journal	February 2005
One-step synthesis of silver nanoparticles using carbon dots as reducing and stabilizing agents and their antibacterial mechanisms Jin, Jian-Cheng; Xu, Zi-Qiang; Dong, Ping Carbon, Vol. 94 https://doi.org/10.1016/j.carbon.2015.05.084	journal	November 2015
Solar-Light-Driven Photocatalytic Activity of Novel Sn@C-Dots-Modified TiO ₂ Catalyst Kumar, Vijay Bhooshan; Perkas, Nina; Porat, Ze'ev ChemistrySelect, Vol. 2, Issue 23 https://doi.org/10.1002/slct.201701375	journal	August 2017
The sonochemical synthesis of Ga@C-dots particles Kumar, Vijay Bhooshan; Perelshtein, Ilana; Lipovsky, Anat RSC Advances, Vol. 5, Issue 32 https://doi.org/10.1039/C5RA01101A	journal	January 2015
Lanthanide Doped Near Infrared Active Upconversion Nanophosphors: Fundamental Concepts, Synthesis Strategies, and Technological Applications Lingeshwar Reddy, Kumbam; Balaji, Ramachandran; Kumar, Ashish Small, Vol. 14, Issue 37 https://doi.org/10.1002/smll.201801304	journal	July 2018
Facile synthesis of pristine graphene-palladium nanocomposites with extraordinary catalytic activities using swollen liquid crystals Vats, T.; Dutt, S.; Kumar, R. Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep33053	journal	September 2016
"In vivo" monitoring of neuronal network activity in zebrafish by two-photon Ca2+ imaging Brustein, E.; Marandi, N.; Kovalchuk, Y. Pflügers Archiv - European Journal of Physiology, Vol. 446, Issue 6 https://doi.org/10.1007/s00424-003-1138-4	journal	July 2003
Glowing Graphene Quantum Dots and Carbon Dots: Properties, Syntheses, and Biological Applications Zheng, Xin Ting; Ananthanarayanan, Arundithi; Luo, Kathy Qian Small, Vol. 11, Issue 14 https://doi.org/10.1002/smll.201402648	journal	December 2014
The in vitro and in vivo toxicity of graphene quantum dots Chong, Yu; Ma, Yufei; Shen, He Biomaterials, Vol. 35, Issue 19 https://doi.org/10.1016/j.biomaterials.2014.03.021	journal	June 2014
Doped Carbon Dots for Sensing and Bioimaging Applications: A Minireview Atabaev, Timur Nanomaterials, Vol. 8, Issue 5 https://doi.org/10.3390/nano8050342	journal	May 2018
Boron and nitrogen co-doped carbon dots as a sensitive fluorescent probe for the detection of curcumin Bian, Wei; Wang, Xuan; Wang, Yakun Luminescence, Vol. 33, Issue 1 https://doi.org/10.1002/bio.3390	journal	September 2017
Graphene based materials: Past, present and future Singh, Virendra; Joung, Daeha; Zhai, Lei Progress in Materials Science, Vol. 56, Issue 8 https://doi.org/10.1016/j.pmatsci.2011.03.003	journal	October 2011
Facile one-step sonochemical synthesis of ultrafine and stable fluorescent C-dots Kumar, Vijay Bhooshan; Porat, Ze’ev; Gedanken, Aharon Ultrasonics Sonochemistry, Vol. 28 https://doi.org/10.1016/j.ultsonch.2015.08.005	journal	January 2016
Antiparasitic Ointment Based on a Biocompatibile Carbon Dot Nanocomposite Kumar, Vijay Bhooshan; Dolitzky, Avishay; Michaeli, Shulamit ACS Applied Nano Materials, Vol. 1, Issue 4 https://doi.org/10.1021/acsanm.8b00213	journal	March 2018
Semiconductor Clusters, Nanocrystals, and Quantum Dots Alivisatos, A. P. Science, Vol. 271, Issue 5251, p. 933-937 https://doi.org/10.1126/science.271.5251.933	journal	February 1996
Iron oxide nanoparticles for neuronal cell applications: uptake study and magnetic manipulations Marcus, Michal; Karni, Moshe; Baranes, Koby Journal of Nanobiotechnology, Vol. 14, Issue 1 https://doi.org/10.1186/s12951-016-0190-0	journal	May 2016
Non-heavy-metal ZnS quantum dots with bright blue photoluminescence by a one-step aqueous synthesis Li, Hui; Shih, Wan Y.; Shih, Wei-Heng Nanotechnology, Vol. 18, Issue 20 https://doi.org/10.1088/0957-4484/18/20/205604	journal	April 2007
Carbon Quantum Dots Induced Ultrasmall BiOI Nanosheets with Assembled Hollow Structures for Broad Spectrum Photocatalytic Activity and Mechanism Insight Di, Jun; Xia, Jiexiang; Ji, Mengxia Langmuir, Vol. 32, Issue 8 https://doi.org/10.1021/acs.langmuir.5b04308	journal	February 2016
Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy Hong, Guosong; Diao, Shuo; Antaris, Alexander L. Chemical Reviews, Vol. 115, Issue 19 https://doi.org/10.1021/acs.chemrev.5b00008	journal	April 2015
Unusual anti-leukemia activity of nanoformulated naproxen and other non-steroidal anti-inflammatory drugs Kumar, Raj; Siril, Prem Felix; Javid, Farideh Materials Science and Engineering: C, Vol. 69 https://doi.org/10.1016/j.msec.2016.08.024	journal	December 2016
Synthesis of Sulfur-Selenium Doped Carbon Quantum Dots for Biological Imaging and Scavenging Reactive Oxygen Species Huang, Guojie; Lin, Yaqi; Zhang, Linxiu Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-55996-w	journal	December 2019
Iron oxide nanoparticles for neuronal cell applications: uptake study and magnetic manipulations. Marcus, M.; Karni, M.; Baranes, Koby Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.9619	text	January 2016

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36 MATERIALS SCIENCE
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Doped carbon dots
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Hydrothermal process
Nanoparticle
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Neural tissue engineering

Title: One-Pot Hydrothermal Synthesis of Elements (B, N, P)-Doped Fluorescent Carbon Dots for Cell Labelling, Differentiation and Outgrowth of Neuronal Cells

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