Genome-wide analysis of cytochrome P450s of Trichoderma spp.: annotation and evolutionary relationships

Chadha, Sonia; Mehetre, Sayaji T.; Bansal, Ravindra; Kuo, Alan; Aerts, Andrea; Grigoriev, Igor V.; Druzhinina, Irina S.; Mukherjee, Prasun K.

doi:10.1186/s40694-018-0056-3

Genome-wide analysis of cytochrome P450s of Trichoderma spp.: annotation and evolutionary relationships

Journal Article · Mon Jun 04 00:00:00 EDT 2018 · Fungal Biology and Biotechnology

DOI:https://doi.org/10.1186/s40694-018-0056-3· OSTI ID:1544287

Chadha, Sonia ^[1]; Mehetre, Sayaji T. ^[1]; Bansal, Ravindra ^[1]; Kuo, Alan ^[2]; Aerts, Andrea ^[2]; Grigoriev, Igor V. ^[2]; Druzhinina, Irina S. ^[3]; Mukherjee, Prasun K. ^[1]

Bhabha Atomic Research Centre (BARC), Mumbai (India)
USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States)
Technische Univ. Wien, Vienna (Austria)

Background

Cytochrome P450s form an important group of enzymes involved in xenobiotics degradation and metabolism, both primary and secondary. These enzymes are also useful in industry as biotechnological tools for bioconversion and a few are reported to be involved in pathogenicity. Trichoderma spp. are widely used in industry and agriculture and are known for their biosynthetic potential of a large number of secondary metabolites. For realising the full biosynthetic potential of an organism, it is important to do a genome-wide annotation and cataloguing of these enzymes.

Results

Here, we have studied the genomes of seven species (T. asperellum, T. atroviride, T. citrinoviride, T. longibrachiatum, T. reesei , T. harzianum and T. virens) and identified a total of 477 cytochrome P450s. We present here the classification, evolution and structure as well as predicted function of these proteins. This study would pave the way for functional characterization of these groups of enzymes and will also help in realization of their full economic potential.

Conclusion

Our CYPome annotation and evolutionary studies of the seven Trichoderma species now provides opportunities for exploration of research-driven strategies to select Trichoderma species for various applications especially in relation to secondary metabolism and degradation of environmental pollutants.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1544287

Alternate ID(s):: OSTI ID: 1619085

Journal Information:: Fungal Biology and Biotechnology, Journal Name: Fungal Biology and Biotechnology Journal Issue: 1 Vol. 5; ISSN 2054-3085

Publisher:: BioMed Central, Ltd.Copyright Statement

Country of Publication:: United States

Language:: English

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Genome-wide analysis of cytochrome P450s of Trichoderma spp.: annotation and evolutionary relationships Chadha, Sonia; Mehetre, Sayaji; Bansal, Ravindra https://doi.org/10.6084/M9.FIGSHARE.C.4121729 The current record is supplemented by this collection	collection	January 2018
MOESM1 of Genome-wide analysis of cytochrome P450s of Trichoderma spp.: annotation and evolutionary relationships Chadha, Sonia; Mehetre, Sayaji; Bansal, Ravindra https://doi.org/10.6084/m9.figshare.6427391 The current record is supplemented by this text	text	January 2018
MOESM1 of Genome-wide analysis of cytochrome P450s of Trichoderma spp.: annotation and evolutionary relationships Chadha, Sonia; Mehetre, Sayaji; Bansal, Ravindra https://doi.org/10.6084/m9.figshare.6427391.v1 The current record is supplemented by this text	text	January 2018
Genome-wide analysis of cytochrome P450s of Trichoderma spp.: annotation and evolutionary relationships Chadha, Sonia; Mehetre, Sayaji; Bansal, Ravindra https://doi.org/10.6084/m9.figshare.c.4121729.v1 The current record is supplemented by this collection	collection	January 2018

Genome-wide analysis of cytochrome P450s of Trichoderma spp.: annotation and evolutionary relationships

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