Beta cells in type 1 diabetes: mass and function; sleeping or dead?
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journal
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February 2019 |
The role of inflammation in insulitis and β-cell loss in type 1 diabetes
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journal
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April 2009 |
Complementing the Genome with an "Exposome": The Outstanding Challenge of Environmental Exposure Measurement in Molecular Epidemiology
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August 2005 |
Type 1 diabetes
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journal
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June 2018 |
Etiology of Type 1 Diabetes
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journal
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April 2010 |
Genetic risk factors for type 1 diabetes
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journal
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June 2016 |
Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25 year period 1989–2013: a multicentre prospective registration study
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journal
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November 2018 |
Estimated Life Expectancy in a Scottish Cohort With Type 1 Diabetes, 2008-2010
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journal
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January 2015 |
Life expectancy of type 1 diabetic patients during 1997–2010: a national Australian registry-based cohort study
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journal
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January 2016 |
Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association
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journal
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September 2015 |
Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial
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journal
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December 2013 |
Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients
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journal
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July 2015 |
Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA 1c in New-Onset Type 1 Diabetes
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journal
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July 2018 |
Mass-spectrometric exploration of proteome structure and function
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journal
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September 2016 |
Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics
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journal
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May 2002 |
Isobaric Labeling-Based Relative Quantification in Shotgun Proteomics
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journal
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November 2014 |
Tools for Label-free Peptide Quantification
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journal
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December 2012 |
Quantitative mass spectrometry in proteomics: a critical review
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journal
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August 2007 |
Advances in targeted proteomics and applications to biomedical research
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journal
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August 2016 |
Contributions of immunoaffinity chromatography to deep proteome profiling of human biofluids
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journal
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May 2016 |
Combining laser capture microdissection and proteomics: Methodologies and clinical applications
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journal
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February 2010 |
Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry
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journal
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March 1992 |
Constitutive and Inflammatory Immunopeptidome of Pancreatic -Cells
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journal
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August 2012 |
Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors
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journal
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December 2018 |
When one becomes many-Alternative splicing in β-cell function and failure
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journal
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September 2018 |
Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
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journal
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February 2016 |
A roadmap of the generation of neoantigens as targets of the immune system in type 1 diabetes
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journal
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December 2016 |
Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes
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journal
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October 2013 |
Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators
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journal
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March 2015 |
Alternative isoform regulation in human tissue transcriptomes
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journal
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November 2008 |
Peptide splicing by the proteasome
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journal
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November 2017 |
A large fraction of HLA class I ligands are proteasome-generated spliced peptides
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journal
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October 2016 |
Identification of Hybrid Insulin Peptides (HIPs) in Mouse and Human Islets by Mass Spectrometry
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journal
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December 2018 |
Do post-translational beta cell protein modifications trigger type 1 diabetes?
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journal
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September 2013 |
Human islets and dendritic cells generate post-translationally modified islet autoantigens: Post-Translational Modification by Human Islets and DC
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journal
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May 2016 |
PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease
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journal
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November 2003 |
Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4 + T Cells in Patients With Type 1 Diabetes
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journal
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April 2018 |
Citrullinated Glucose-Regulated Protein 78 Is an Autoantigen in Type 1 Diabetes
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journal
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September 2014 |
Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes
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journal
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October 2018 |
Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes
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journal
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January 2017 |
IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells
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journal
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January 2018 |
PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction
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journal
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October 2018 |
A Comprehensive Analysis of Cytokine-induced and Nuclear Factor-κB-dependent Genes in Primary Rat Pancreatic β-Cells
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journal
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October 2001 |
Conditional and specific NF- B blockade protects pancreatic beta cells from diabetogenic agents
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journal
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March 2006 |
Proteomics Analysis of Cytokine-induced Dysfunction and Death in Insulin-producing INS-1E Cells: New Insights into the Pathways Involved
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journal
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October 2007 |
DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway
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journal
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November 2018 |
Viral infections in type 1 diabetes mellitus — why the β cells?
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journal
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March 2016 |
Coxsackievirus-Induced Proteomic Alterations in Primary Human Islets Provide Insights for the Etiology of Diabetes
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journal
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September 2017 |
Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells
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journal
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June 2015 |
TiSH — a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC
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journal
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October 2012 |
Quantitative Phosphoproteomics Revealed Glucose-Stimulated Responses of Islet Associated with Insulin Secretion
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journal
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October 2015 |
Characterization of the Molecular Mechanisms Underlying Glucose Stimulated Insulin Secretion from Isolated Pancreatic β-cells Using Post-translational Modification Specific Proteomics (PTMomics)
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journal
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November 2017 |
Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion
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journal
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November 2016 |
Characterization of Membrane-shed Microvesicles from Cytokine-stimulated β-Cells Using Proteomics Strategies
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journal
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February 2012 |
Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells
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journal
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March 2019 |
The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus
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journal
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November 2007 |
Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation
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journal
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November 2012 |
ER Stress in Pancreatic Cells: The Thin Red Line Between Adaptation and Failure
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journal
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February 2010 |
Novel Insights into the Global Proteome Responses of Insulin-Producing INS-1E Cells To Different Degrees of Endoplasmic Reticulum Stress
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journal
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October 2010 |
Early differences in islets from prediabetic NOD mice: combined microarray and proteomic analysis
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journal
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January 2017 |
GATA Factors Promote ER Integrity and β-Cell Survival and Contribute to Type 1 Diabetes Risk
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journal
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January 2014 |
Islet -Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model
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journal
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March 2012 |
Restoration of the Unfolded Protein Response in Pancreatic Cells Protects Mice Against Type 1 Diabetes
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journal
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November 2013 |
Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes
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journal
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June 2012 |
Characterization of hydroxyl radical modified GAD 65 : A potential autoantigen in type 1 diabetes
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journal
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January 2009 |
The insulin A-chain epitope recognized by human T cells is posttranslationally modified
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journal
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October 2005 |
Recognition of Posttranslationally Modified GAD65 Epitopes in Subjects With Type 1 Diabetes
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journal
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April 2014 |
Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes
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journal
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February 2017 |
Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes
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journal
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December 2012 |
Discovery and Validation of Serum Protein Changes in Type 1 Diabetes Patients Using High Throughput Two Dimensional Liquid Chromatography-Mass Spectrometry and Immunoassays
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journal
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September 2011 |
Peptide serum markers in islet autoantibody-positive children
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journal
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November 2016 |
Serum Proteomes Distinguish Children Developing Type 1 Diabetes in a Cohort With HLA-Conferred Susceptibility
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journal
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January 2015 |
Quantitative Differences in the Urinary Proteome of Siblings Discordant for Type 1 Diabetes Include Lysosomal Enzymes
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journal
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June 2015 |
Type 1 Diabetes: Urinary Proteomics and Protein Network Analysis Support Perturbation of Lysosomal Function
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journal
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January 2017 |
Serum biomarkers for diagnosis and prediction of type 1 diabetes
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journal
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November 2018 |
High-Abundance Polypeptides of the Human Plasma Proteome Comprising the Top 4 Logs of Polypeptide Abundance
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journal
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August 2008 |
Quantitative variability of 342 plasma proteins in a human twin population
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journal
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February 2015 |
Plasma Proteome Profiling to Assess Human Health and Disease
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journal
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March 2016 |
Temporal expression profiling of plasma proteins reveals oxidative stress in early stages of Type 1 Diabetes progression
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journal
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February 2018 |
Deep-Dive Targeted Quantification for Ultrasensitive Analysis of Proteins in Nondepleted Human Blood Plasma/Serum and Tissues
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journal
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August 2017 |
Progression to Diabetes in Relatives of Type 1 Diabetic Patients: Mechanisms and Mode of Onset
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journal
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December 2009 |
Patterns of Metabolic Progression to Type 1 Diabetes in the Diabetes Prevention Trial-Type 1
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journal
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February 2006 |
β Cell dysfunction exists more than 5 years before type 1 diabetes diagnosis
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journal
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August 2018 |
Elevations in the Fasting Serum Proinsulin–to–C-Peptide Ratio Precede the Onset of Type 1 Diabetes
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journal
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July 2016 |
Measurement of Pro-Islet Amyloid Polypeptide (1–48) in Diabetes and Islet Transplants
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journal
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March 2017 |
Circulating microRNAs as novel biomarkers for diabetes mellitus
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journal
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April 2013 |
MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells
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journal
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March 2017 |
MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells
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journal
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October 2016 |
The MicroRNA Spectrum in 12 Body Fluids
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journal
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September 2010 |
Profiling of circulating microRNAs in children with recent onset of type 1 diabetes
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journal
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February 2017 |
Association of serum microRNAs with islet autoimmunity, disease progression and metabolic impairment in relatives at risk of type 1 diabetes
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journal
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May 2017 |
Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development
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journal
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February 2019 |
Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes
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journal
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February 2018 |
Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes
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journal
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July 2017 |
Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity
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journal
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November 2016 |
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
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journal
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June 2015 |
A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)γa as a pancreatic beta cell-specific biomarker
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journal
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April 2010 |
Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue
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journal
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March 2017 |
Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma
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journal
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May 2015 |
Acoustic Purification of Extracellular Microvesicles
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journal
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February 2015 |
Detection of cell death in diabetes using differentially methylated circulating DNA
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journal
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November 2011 |
Detection of Islet β-Cell Death in Vivo by Multiplex PCR Analysis of Differentially Methylated DNA
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journal
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September 2013 |
Identification of tissue-specific cell death using methylation patterns of circulating DNA
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journal
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March 2016 |
β Cell death and dysfunction during type 1 diabetes development in at-risk individuals
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journal
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February 2015 |
Circulating Differentially Methylated Amylin DNA as a Biomarker of β-Cell Loss in Type 1 Diabetes
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journal
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April 2016 |
Glucokinase Gene May Be a More Suitable Target Than the Insulin Gene for Detection of β Cell Death
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journal
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May 2017 |
Quantitative proteomic analysis of single pancreatic islets
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journal
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October 2009 |
Proteomic profiling of human islets collected from frozen pancreata using laser capture microdissection
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journal
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January 2017 |
Comparative quantitative proteomic analysis of disease stratified laser captured microdissected human islets identifies proteins and pathways potentially related to type 1 diabetes
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journal
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September 2017 |
Spatially-Resolved Proteomics: Rapid Quantitative Analysis of Laser Capture Microdissected Alveolar Tissue Samples
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journal
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December 2016 |
Development and Evaluation of a Micro- and Nanoscale Proteomic Sample Preparation Method
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journal
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December 2005 |
An Integrated Platform for Isolation, Processing, and Mass Spectrometry-based Proteomic Profiling of Rare Cells in Whole Blood
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journal
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March 2015 |
Ultrasensitive Proteome Profiling for 100 Living Cells by Direct Cell Injection, Online Digestion and Nano-LC-MS/MS Analysis
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journal
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June 2015 |
Nanoliter-Scale Oil-Air-Droplet Chip-Based Single Cell Proteomic Analysis
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journal
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March 2018 |
SCoPE-MS: mass spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation
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journal
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October 2018 |
Nanodroplet processing platform for deep and quantitative proteome profiling of 10–100 mammalian cells
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journal
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February 2018 |
Heterogeneity of the Human Pancreatic Islet
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journal
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April 2019 |
Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of <1000 mammalian cells
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journal
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January 2018 |
Integrating ion mobility spectrometry into mass spectrometry-based exposome measurements: what can it add and how far can it go?
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journal
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January 2017 |
SPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in biofluids
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journal
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December 2016 |
Online Parallel Accumulation–Serial Fragmentation (PASEF) with a Novel Trapped Ion Mobility Mass Spectrometer
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journal
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November 2018 |
Experimental Evaluation and Optimization of Structures for Lossless Ion Manipulations for Ion Mobility Spectrometry with Time-of-Flight Mass Spectrometry
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journal
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September 2014 |
Nanowell-mediated multidimensional separations combining nanoLC with SLIM IM-MS for rapid, high-peak-capacity proteomic analyses
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journal
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November 2018 |
Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
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journal
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May 2011 |
Multiplexed Epitope-Based Tissue Imaging for Discovery and Healthcare Applications
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journal
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April 2016 |
Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas
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journal
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October 2016 |
The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation
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journal
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October 2009 |
Mass Cytometry Identifies Distinct Subsets of Regulatory T Cells and Natural Killer Cells Associated With High Risk for Type 1 Diabetes
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journal
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May 2019 |
A Public BCR Present in a Unique Dual-Receptor-Expressing Lymphocyte from Type 1 Diabetes Patients Encodes a Potent T Cell Autoantigen
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journal
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May 2019 |
Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes
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journal
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March 2019 |
A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry
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journal
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March 2019 |