Molecular sleds and uses thereof

Mangel, Walter F.; Blainey, Paul C.; Graziano, Vito; Herrmann, Andreas; McGrath, William J.; Van Oijen, Antonius Martinus; Xie, Xiaoliang Sunney

Title: Molecular sleds and uses thereof

Patent · Tue Sep 04 00:00:00 EDT 2018

OSTI ID:1531360

Mangel, Walter F.; Blainey, Paul C.; Graziano, Vito; Herrmann, Andreas; McGrath, William J.; Van Oijen, Antonius Martinus; Xie, Xiaoliang Sunney

The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.

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Research Organization:: The Broad Institute, Inc., Cambridge, MA (United States); Harvard Univ., Cambridge, MA (United States); Rijksuniversiteit Groningen (Netherlands)

Sponsoring Organization:: USDOE

Assignee:: The Broad Institute, Inc. (Cambridge, MA); President and Fellows of Harvard College (Cambridge, MA); Rijksuniversiteit Groningen (Groningen, CH)

Patent Number(s):: 10,065,989

Application Number:: 14/595,941

OSTI ID:: 1531360

Resource Relation:: Patent File Date: 2015-01-13

Country of Publication:: United States

Language:: English

References (22)

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