skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Compounds, compositions, pharmaceutical compositions, and methods of use

Abstract

Certain embodiments of the invention include compositions comprising a compound of Formula (I), and salts, isomers, and derivatives thereof. Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I), and salts, isomers, and derivatives thereof. Other embodiments of this invention include methods for treating disease (e.g., cancer) and methods for administering a compound of Formula (I), and salts, isomers, and derivatives thereof.

Inventors:
; ; ;
Publication Date:
Research Org.:
University of Louisville Research Foundation, Inc. Louisville, KY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1332312
Patent Number(s):
9,492,428
Application Number:
14/358,731
Assignee:
University of Louisville Research Foundation, Inc. (Louisville, KY)
DOE Contract Number:  
FG02-08CH11538
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Nov 16
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Hammond, Gerald B., Jin, Zhuang, Bates, Paula J., and Reyes-Reyes, Elsa Merit. Compounds, compositions, pharmaceutical compositions, and methods of use. United States: N. p., 2016. Web.
Hammond, Gerald B., Jin, Zhuang, Bates, Paula J., & Reyes-Reyes, Elsa Merit. Compounds, compositions, pharmaceutical compositions, and methods of use. United States.
Hammond, Gerald B., Jin, Zhuang, Bates, Paula J., and Reyes-Reyes, Elsa Merit. Tue . "Compounds, compositions, pharmaceutical compositions, and methods of use". United States. https://www.osti.gov/servlets/purl/1332312.
@article{osti_1332312,
title = {Compounds, compositions, pharmaceutical compositions, and methods of use},
author = {Hammond, Gerald B. and Jin, Zhuang and Bates, Paula J. and Reyes-Reyes, Elsa Merit},
abstractNote = {Certain embodiments of the invention include compositions comprising a compound of Formula (I), and salts, isomers, and derivatives thereof. Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I), and salts, isomers, and derivatives thereof. Other embodiments of this invention include methods for treating disease (e.g., cancer) and methods for administering a compound of Formula (I), and salts, isomers, and derivatives thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {11}
}

Patent:

Save / Share:

Works referenced in this record:

Anti-Infective and Cytotoxic Compounds Present in Blepharodon nitidum
journal, March 2008


Isolation of Cytotoxic Metabolites from Targeted Peruvian Amazonian Medicinal Plants
journal, January 2008

  • Aponte, José C.; Vaisberg, Abraham J.; Rojas, Rosario
  • Journal of Natural Products, Vol. 71, Issue 1
  • DOI: 10.1021/np070560c

A Multipronged Approach to the Study of Peruvian Ethnomedicinal Plants: A Legacy of the ICBG-Peru Project
journal, March 2009

  • Aponte, José C.; Vaisberg, Abraham J.; Rojas, Rosario
  • Journal of Natural Products, Vol. 72, Issue 3
  • DOI: 10.1021/np800630k

Cytotoxic and Anti-infective Sesquiterpenes Present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae)
journal, December 2009


Cytotoxic and Anti-infective Phenolic Compounds Isolated from Mikania decora and Cremastosperma microcarpum
journal, April 2011


Antinociceptive effect of the aqueous extract obtained from roots of Physalis angulata L. on mice
journal, January 2006

  • Bastos, G. N. T.; Santos, A. R. S.; Ferreira, V. M. M.
  • Journal of Ethnopharmacology, Vol. 103, Issue 2, p. 241-245
  • DOI: 10.1016/j.jep.2005.08.008

Physalis angulata extract exerts anti-inflammatory effects in rats by inhibiting different pathways
journal, July 2008

  • Bastos, G. N. T.; Silveira, A. J. A.; Salgado, C. G.
  • Journal of Ethnopharmacology, Vol. 118, Issue 2, p. 246-251
  • DOI: 10.1016/j.jep.2008.04.005

Activity of Physalin F in a Collagen-Induced Arthritis Model
journal, August 2010

  • Brustolim, Daniele; Vasconcelos, Juliana F.; Freitas, Luiz Antônio R.
  • Journal of Natural Products, Vol. 73, Issue 8
  • DOI: 10.1021/np900691w

Antigonorrhoeal activity of plants used in Guatemala for the treatment of sexually transmitted diseases
journal, October 1995


Immune depression in Rhodnius prolixus by seco-steroids, physalins
journal, March 2008


Natural withanolides: an overview
journal, January 2011

  • Chen, Li-Xia; He, Hao; Qiu, Feng
  • Natural Product Reports, Vol. 28, Issue 4
  • DOI: 10.1039/C0NP00045K

Molluscicidal activity of Physalis angulata L. extracts and fractions on Biomphalaria tenagophila (d'Orbigny, 1835) under laboratory conditions
journal, April 2003

  • Santos, José Augusto A. dos; Tomassini, Therezinha Coelho B.; Xavier, Deise Cristina Drummond
  • Memórias do Instituto Oswaldo Cruz, Vol. 98, Issue 3
  • DOI: 10.1590/S0074-02762003000300024

Withanolides and related ergostane-type steroids
journal, January 1991


Inhibitory effects of Physalis angulata on tumor metastasis and angiogenesis
journal, June 2011

  • Hseu, You-Cheng; Wu, Chi-Rei; Chang, Hsueh-Wei
  • Journal of Ethnopharmacology, Vol. 135, Issue 3, p. 762-771
  • DOI: 10.1016/j.jep.2011.04.016

Physalis angulata induced G2/M phase arrest in human breast cancer cells
journal, July 2006

  • Hsieh, Wen-Tsong; Huang, Kuan-Yuh; Lin, Hui-Yi
  • Food and Chemical Toxicology, Vol. 44, Issue 7, p. 974-983
  • DOI: 10.1016/j.fct.2005.11.013

Antimycobacterial physalins from Physalis angulata L. (Solanaceae) : ANTIMYCOBACTERIAL PHYSALINS
journal, August 2002

  • Januário, A. H.; Filho, E. Rodrigues; Pietro, R. C. L. R.
  • Phytotherapy Research, Vol. 16, Issue 5
  • DOI: 10.1002/ptr.939

Physangulidines A, B, and C: Three New Antiproliferative Withanolides from Physalis angulata L.
journal, February 2012

  • Jin, Zhuang; Mashuta, Mark S.; Stolowich, Neal J.
  • Organic Letters, Vol. 14, Issue 5
  • DOI: 10.1021/ol203498a

Physanolide A, a Novel Skeleton Steroid, and Other Cytotoxic Principles from Physalis a ngulata
journal, July 2006

  • Kuo, Ping-Chung; Kuo, Tsung-Hsiao; Damu, Amooru G.
  • Organic Letters, Vol. 8, Issue 14
  • DOI: 10.1021/ol060801s

New cytotoxic withanolides from Physalis peruviana
journal, September 2009


Induction of heat-shock response and alterations of protein phosphorylation by a novel topoisomerase ii inhibitor, withangulatin A, in 9L rat brain tumor cells
journal, October 1991

  • Lee, Wen-Chuan; Lin, Kae-Yuan; Chen, Chiu-Ming
  • Journal of Cellular Physiology, Vol. 149, Issue 1
  • DOI: 10.1002/jcp.1041490110

Oxidative stress involvement in Physalis angulata-induced apoptosis in human oral cancer cells
journal, March 2009

  • Lee, H.-Z.; Liu, W.-Z.; Hsieh, W.-T.
  • Food and Chemical Toxicology, Vol. 47, Issue 3, p. 561-570
  • DOI: 10.1016/j.fct.2008.12.013

Withajardins, withanolides with a new type of skeleton structure of withajardins A, B, C and D absolute configuration of withajardin C
journal, January 1994


In-vitro and in-vivo antitumour activity of physalins B and D from Physalis angulata
journal, February 2006

  • Magalhães, Hemerson Iury Ferreira; Torres, Márcia Rocha; Costa-Lotufo, Letícia Veras
  • Journal of Pharmacy and Pharmacology, Vol. 58, Issue 2
  • DOI: 10.1211/jpp.58.2.0011

Antimicrobial activity of essential oils of <i>Physalis angulata</i> L
journal, July 2010

  • Osho, A.; Adetunji, T.; Fayemi, So
  • African Journal of Traditional, Complementary and Alternative Medicines, Vol. 7, Issue 4
  • DOI: 10.4314/ajtcam.v7i4.56696

Topical anti-inflammatory potential of Physalin E from Physalis angulata on experimental dermatitis in mice
journal, August 2010


Chemically Engineered Extracts: Source of Bioactive Compounds
journal, April 2011

  • Ramallo, I. Ayelen; Salazar, Mario O.; Mendez, Luciana
  • Accounts of Chemical Research, Vol. 44, Issue 4
  • DOI: 10.1021/ar100106n

Physangulidine A, a Withanolide from Physalis angulata , Perturbs the Cell Cycle and Induces Cell Death by Apoptosis in Prostate Cancer Cells
journal, December 2012

  • Reyes-Reyes, E. Merit; Jin, Zhuang; Vaisberg, Abraham J.
  • Journal of Natural Products, Vol. 76, Issue 1
  • DOI: 10.1021/np300457g

Antimalarial Activity of Physalins B, D, F, and G
journal, October 2011

  • Sá, Matheus S.; de Menezes, Maria N.; Krettli, Antoniana U.
  • Journal of Natural Products, Vol. 74, Issue 10
  • DOI: 10.1021/np200260f

Inhibition of macrophage activation and lipopolysaccaride-induced death by seco-steroids purified from Physalis angulata L.
journal, January 2003

  • Soares, Milena B. P.; Bellintani, Moema C.; Ribeiro, Ivone M.
  • European Journal of Pharmacology, Vol. 459, Issue 1, p. 107-112
  • DOI: 10.1016/S0014-2999(02)02829-7

Apoptosis: why and how does it occur in biology?: APOPTOSIS IN BIOLOGY
journal, July 2011

  • Ulukaya, Engin; Acilan, Ceyda; Yilmaz, Yusuf
  • Cell Biochemistry and Function, Vol. 29, Issue 6
  • DOI: 10.1002/cbf.1774

Antihepatoma activity of Physalis angulata and P. peruviana extracts and their effects on apoptosis in human Hep G2 cells
journal, March 2004

  • Wu, Shu-Jing; Ng, Lean-Teik; Chen, Ching-Hsein
  • Life Sciences, Vol. 74, Issue 16, p. 2061-2073
  • DOI: 10.1016/j.lfs.2003.09.058

Some practical considerations and applications of the national cancer institute in vitro anticancer drug discovery screen
journal, February 1995

  • Boyd, Michael R.; Paull, Kenneth D.
  • Drug Development Research, Vol. 34, Issue 2
  • DOI: 10.1002/ddr.430340203

Cancer-selective antiproliferative activity is a general property of some G-rich oligodeoxynucleotides
journal, December 2009

  • Choi, Enid W.; Nayak, Lalitha V.; Bates, Paula J.
  • Nucleic Acids Research, Vol. 38, Issue 5
  • DOI: 10.1093/nar/gkp1088

Isolation, Structures, and Structure−Cytotoxic Activity Relationships of Withanolides and Physalins from Physalis angulata
journal, July 2007

  • Damu, Amooru G.; Kuo, Ping-Chung; Su, Chung-Ren
  • Journal of Natural Products, Vol. 70, Issue 7
  • DOI: 10.1021/np0701374

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening
journal, July 1990

  • Skehan, P.; Storeng, R.; Scudiero, D.
  • JNCI Journal of the National Cancer Institute, Vol. 82, Issue 13
  • DOI: 10.1093/jnci/82.13.1107