Effects of carotenoids on lipid bilayers

Johnson, Quentin R.; Mostofian, Barmak; Gomez, Gabriel Fuente; Smith, Jeremy C.; Cheng, Xiaolin

doi:10.1039/C7CP07126D

Title: Effects of carotenoids on lipid bilayers

Journal Article · Tue Jan 09 00:00:00 EST 2018 · Physical Chemistry Chemical Physics. PCCP

DOI:https://doi.org/10.1039/C7CP07126D· OSTI ID:1531265

^[1]; Mostofian, Barmak ^[2]; Gomez, Gabriel Fuente ^[3];

^[4];

^[2]

Univ. of Tennessee, Knoxville, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Univ. of Tennessee, Knoxville, TN (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)

Carotenoids have been found to be important in improving the integrity of biomembranes in eukaryotes. However, the molecular details of how carotenoids modulate the physical properties of biomembranes are unknown. To this end, we have conducted a series of molecular dynamics simulations of different biologically-relevant membranes in the presence of carotenoids. The carotenoid effect on the membrane was found to be specific to the identity of the carotenoid and the composition of the membrane itself. Therefore, different classes of carotenoids produce a different effect on the membrane, and different membrane phases are affected differently by carotenoids. It is apparent from our data that carotenoids do trigger the bilayer to become thinner. The mechanism by which this occurs depends on two competing factors, the ability of the lipid tails of opposing monolayers to either (1) compress or (2) interdigitate as the bilayer condenses. Indeed, carotenoids directly influence the physical properties via these two mechanisms, thus compacting the bilayer. Furthermore, the degree to which these competing mechanisms are utilized depends on the bilayer phase and the carotenoid identity.

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Research Organization:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1531265

Journal Information:: Physical Chemistry Chemical Physics. PCCP, Vol. 20, Issue 5; ISSN 1463-9076

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 15 works

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The non‐homogenous distribution and aggregation of carotenoids in the stratum corneum correlates with the organization of intercellular lipids in vivo Choe, ChunSik; Ri, JaeRyong; Schleusener, Johannes Experimental Dermatology, Vol. 28, Issue 11 https://doi.org/10.1111/exd.14018	journal	September 2019
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