Effects of carotenoids on lipid bilayers

Johnson, Quentin R.; Mostofian, Barmak; Fuente Gomez, Gabriel; Smith, Jeremy C.; Cheng, Xiaolin

doi:10.1039/c7cp07126d

Effects of carotenoids on lipid bilayers

Journal Article · Sun Dec 31 23:00:00 EST 2017 · Physical Chemistry Chemical Physics. PCCP

DOI:https://doi.org/10.1039/c7cp07126d· OSTI ID:1492842

^[1]; Mostofian, Barmak ^[2]; Fuente Gomez, Gabriel ^[3]; Smith, Jeremy C. ^[4]; Cheng, Xiaolin ^[2]

National Institute for Mathematical and Biological Synthesis; University of Tennessee; Knoxville; USA; Center for Molecular Biophysics
Center for Molecular Biophysics; Oak Ridge National Lab; Oak Ridge; USA
Department of Biochemistry and Cellular & Molecular Biology; University of Tennessee; Knoxville; USA
Center for Molecular Biophysics; Oak Ridge National Lab; Oak Ridge; USA; Department of Biochemistry and Cellular & Molecular Biology

Carotenoids have been found to be important in improving the integrity of biomembranes in eukaryotes. However, the molecular details of how carotenoids modulate the physical properties of biomembranes are unknown. To this end, we have conducted a series of molecular dynamics simulations of different biologically-relevant membranes in the presence of carotenoids. The carotenoid effect on the membrane was found to be specific to the identity of the carotenoid and the composition of the membrane itself. Therefore, different classes of carotenoids produce a different effect on the membrane, and different membrane phases are affected differently by carotenoids. It is apparent from our data that carotenoids do trigger the bilayer to become thinner. The mechanism by which this occurs depends on two competing factors, the ability of the lipid tails of opposing monolayers to either (1) compress or (2) interdigitate as the bilayer condenses. Indeed, carotenoids directly influence the physical properties via these two mechanisms, thus compacting the bilayer. However, the degree to which these competing mechanisms are utilized depends on the bilayer phase and the carotenoid identity.

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF); Lawrence Berkeley National Laboratory-National Energy Research Scientific Computing Center

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)

DOE Contract Number:: AC02-05CH11231; AC05-00OR22725

OSTI ID:: 1492842

Journal Information:: Physical Chemistry Chemical Physics. PCCP, Journal Name: Physical Chemistry Chemical Physics. PCCP Journal Issue: 5 Vol. 20; ISSN 1463-9076; ISSN PPCPFQ

Country of Publication:: United States

Language:: English

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