Independent Control of Ion Transmission in a Jet Disrupter Dual-Channel Ion Funnel Electrospray Ionization MS Interface
While the use of an internal calibrant can significantly increase mass measurement accuracy in many LC-MS applications, ion suppression in the ESI process and space charge effects in the MS analyzer often limit its effectiveness. These limitations are especially problematic when LC-MS is used for analyzing complex biological samples where both high sensitivity and broad dynamic range are required. To address this need, a new ESI interface has been developed to control ion transmission through the first vacuum stage of the mass spectrometer. The initial design using a dual electrospray, a dual heated capillary and a dual inlet ion funnel (Fig. 1) is specifically aimed at providing a method for controlled introduction of calibrant ions in highly accurate mass measurements using Fourier transform ion cyclotron resonance mass spectrometer.
- Research Organization:
- Pacific Northwest National Lab., Richland, WA (US)
- Sponsoring Organization:
- US Department of Energy (US)
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 15011665
- Report Number(s):
- PNNL-SA-41476; KP1102010; TRN: US200507%%392
- Journal Information:
- Analytical Chemistry, Vol. 74, Issue 20; Other Information: PBD: 17 Sep 2002
- Country of Publication:
- United States
- Language:
- English
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