Letter to the Editor: 1H, 13C and 15N Resonance Assignments for Methionine Sulfoxide Reductase B from Bacillus Subtilis
The presence of reactive oxidants can sometimes cause severe cellular damage, e.g., the loss of protein function through oxidation. In particular, methionine residues of proteins are quite susceptible to oxidation by most reactive oxygen species generated during pathogenic infections, aging or other stress conditions (Weissbach et al., 2002). To prevent this, cells have developed mechanisms to control the cellular level of oxidants. One such antioxidant defense system utilizes the process of oxidation of methionine (Met) residues in proteins to methionine sulfoxide (Met(O)) and reduction of Met(O) to Met (Lowther et al., 2000; Weissbach et al., 2002). The conversion between Met and Met(O) has also been implicated in many other cellular processes, including regulation of protein function (Weissbach et al., 2002). Overall, the Met / Met(O) cycle plays an important role in protecting cells from the deleterious effects of free oxidants.
- Research Organization:
- Pacific Northwest National Lab., Richland, WA (US), Environmental Molecular Sciences Lab. (US)
- Sponsoring Organization:
- US Department of Energy (US)
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 15004345
- Report Number(s):
- PNWD-SA-5912; 2327; TRN: US201015%%543
- Journal Information:
- Journal of Biomolecular NMR, Vol. 27, Issue 2; Other Information: PBD: 1 Oct 2003; ISSN 0925-2738
- Country of Publication:
- United States
- Language:
- English
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