An Integrated Confocal and Magnetic Resonance Microscope for Observing Living Cells
Conference
·
OSTI ID:15001735
We have combined a confocal fluorescence optical microscope and a magnetic resonance microscope into one instrument to image simultaneously a living cell system. The high spatial resolution confocal and high spectral resolution magnetic resonance microscope produces a set of closely linked, complementary images. To enhance the value of this image set, we have also developed a statistical method, local linear modeling, to predict a high spatial resolution magnetic resonance image from the confocal optical and magnetic resonance image pair. This high spatial, high spectral resolution image offers insights not available in images obtained from separate studies, nor available in the viewing the image pair as is. This paper presents first results from application of this instrument and local linear modeling, a statistical prediction technique, to a calibration phantom and a Xenopus laevis oocyte cluster.
- Research Organization:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 15001735
- Report Number(s):
- PNWD-SA-5646
- Country of Publication:
- United States
- Language:
- English
Similar Records
Combined Confocal and Magnetic Resonance Microscopy
Scanning confocal electron microscope
Virtual pinhole confocal microscope
Journal Article
·
Sun May 12 00:00:00 EDT 2002
· Applied Magnetic Resonance, 22(2):145-158
·
OSTI ID:15001400
Scanning confocal electron microscope
Patent
·
Tue Apr 15 00:00:00 EDT 2003
·
OSTI ID:1531454
Virtual pinhole confocal microscope
Technical Report
·
Tue Jun 01 00:00:00 EDT 1999
·
OSTI ID:353183