Trace Determination of Gadolinium in Biomedical Samples by Diode Laser-Based Multi-Step Resonance Ionization Mass Spectrometry

Journal Article · Tue Jan 01 00:00:00 EST 2002 · Analytical and Bioanalytical Chemistry

DOI:https://doi.org/10.1007/s00216-002-1268-0· OSTI ID:15001605

Blaum, K ^[1]; Geppert, C H ^[2]; Schreiber, W G ^[3]; Hengstler, J ^[4]; Muller, P ^[5]; Nortershauser, W ^[6]; Wendt, Klaus ^[7]; Bushaw, Bruce A ^[8]

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1. Institut fur Physik, Johnannes Gutenberg-Universitat
2. Institut fur Physik, Johnannes
3. Universitatsklinik Mainz, Klinik fur Radiologie
4. Institut fur Angewandte Toxikologie, Johannes Gutenberg-Universitat
5. Institut fur Physik, Johannes Gutenberg-Universitat
6. Pacific Northwest National Laboratory
7. Johannes Gutenberg-Universitat
8. BATTELLE (PACIFIC NW LAB)

We report on the application of high-resolution multi-step resonance ionization mass spectrometry (RIMS) to the trace determination of the rare earth element gadolinium. Utilizing three-step resonant excitation into an autoionizing level, we attain both isobaric and isotopic selectivity of > 107. An overall detection efficiency of -10-7 and an isotope specific detection limit of 1.5x109 atoms have been demonstrated. When targeting the major isotope 158Gd, this corresponds to a total Gd detection limit of 1.6 pg. Additionally, linear response has been demonstrated over a dynamic range of six orders of magnitude. The method has been used to determine the GD-content in various normal and tumor tissue samples, taken from a laboratory mouse shortly after injection of Gd-DTPA, which is used as a contrast agent for magnetic resonance imaging (MRI). The RIMS results show Gd concentrations that vary by more than two orders of magnitude depending on the tissue type. This variability is similar to that observed in MRI scans that depict Gd-DTPA content in the mouse prior to dissection, and illustrates the potential for quantitative trace analysis in microsamples of biomedical materials.

• Research Organization: Pacific Northwest National Lab., Richland, WA (US)
• Sponsoring Organization: US Department of Energy (US)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 15001605
• Report Number(s): PNNL-SA-35754; KC0302010; TRN: US200406%%42
• Journal Information: Analytical and Bioanalytical Chemistry, Vol. 372, Issue 7-8; Other Information: PBD: 1 Jan 2002
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
TRACE AMOUNTS
DETECTION
GADOLINIUM
NEOPLASMS
SENSITIVITY
RESONANCE IONIZATION MASS SPECTROSCOPY
ANIMAL TISSUES
MICE