Heterologous pathway to produce terpenes

Keasling, Jay D.; Eiben, Christopher B.

Title: Heterologous pathway to produce terpenes

Patent · Tue Jan 01 00:00:00 EST 2019

OSTI ID:1493489

Keasling, Jay D.; Eiben, Christopher B.

Cells comprising a heterologous metabolic pathway are configured to produce a terpene product containing non-multiples of five carbon, particularly wherein the pathway comprises heterologous Lepidoptera insect juvenile hormone biosynthetic pathway enzymes of the insect's mevalonate pathway.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 10,167,488

Application Number:: 15/803,735

OSTI ID:: 1493489

Resource Relation:: Patent File Date: 2017 Nov 03

Country of Publication:: United States

Language:: English

References (6)

Control of juvenile hormone biosynthesis in Bombyx mori: Cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata Kinjoh, Terunori; Kaneko, Yu; Itoyama, Kyo Insect Biochemistry and Molecular Biology, Vol. 37, Issue 8 https://doi.org/10.1016/j.ibmb.2007.03.008	journal	August 2007
Conversion of a β-Ketoacyl Synthase to a Malonyl Decarboxylase by Replacement of the Active-Site Cysteine with Glutamine Witkowski, Andrzej; Joshi, Anil K.; Lindqvist, Ylva Biochemistry, Vol. 38, Issue 36, p. 11643-11650 https://doi.org/10.1021/bi990993h	journal	September 1999
Melamine Deaminase and Atrazine Chlorohydrolase: 98 Percent Identical but Functionally Different Seffernick, J. L.; de Souza, M. L.; Sadowsky, M. J. Journal of Bacteriology, Vol. 183, Issue 8, p. 2405-2410 https://doi.org/10.1128/JB.183.8.2405-2410.2001	journal	April 2001
Purification, properties and heteromeric association of type-1 and type-2 lepidopteran farnesyl diphosphate synthases Sen, Stephanie E.; Cusson, Michel; Trobaugh, Corey Insect Biochemistry and Molecular Biology, Vol. 37, Issue 8 https://doi.org/10.1016/j.ibmb.2007.05.012	journal	August 2007
The sequence–structure relationship and protein function prediction Sadowski, M.; Jones, D. Current Opinion in Structural Biology, Vol. 19, Issue 3, p. 357-362 https://doi.org/10.1016/j.sbi.2009.03.008	journal	June 2009
Chemoenzymatic preparation of germacrene analogues Cascón, Oscar; Touchet, Sabrina; Miller, David J. Chemical Communications, Vol. 48, Issue 78 https://doi.org/10.1039/c2cc35542f	journal	January 2012

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