Shifted‐excitation Raman difference spectroscopy for the detection of SERS‐encoded gold nanostar probes

Register, Janna; Maiwald, Martin; Fales, Andrew; Strobbia, Pietro; Sumpf, Bernd; Vo‐Dinh, Tuan

doi:10.1002/jrs.5482

Shifted‐excitation Raman difference spectroscopy for the detection of SERS‐encoded gold nanostar probes

Journal Article · Sun Sep 16 00:00:00 EDT 2018 · Journal of Raman Spectroscopy

DOI:https://doi.org/10.1002/jrs.5482· OSTI ID:1472161

Fitzpatrick Institute for Photonics Duke University Durham NC USA, Department of Biomedical Engineering Duke University Durham NC USA
Ferdinand‐Braun‐Institut Leibniz‐Institut für Höchstfrequenztechnik Berlin Germany
Fitzpatrick Institute for Photonics Duke University Durham NC USA, Department of Biomedical Engineering Duke University Durham NC USA, Department of Chemistry Duke University Durham NC USA

Abstract

In vivo applications of surface‐enhanced Raman spectroscopy (SERS) have limited sensitivity due to the intense background signal from real‐life complex samples such as plants and tissues. To overcome this issue, this work investigates the combination of shifted‐excitation Raman difference spectroscopy (SERDS) with SERS nanoprobes to generate background‐free SE‐SERDS spectra. The SERDS technique was performed with a dual‐wavelength diode laser with two emission lines at 785.40 and 785.02 nm. The SERS nanoprobes used for these studies are SERS‐encoded nanostars. The use of the SERDS technique in the detection of SERS nanoprobes was demonstrated by recovering full Raman spectra from a 1 pM concentration of nanoprobes, which only show few peaks in the pure SERS spectra. Background‐free SE‐SERDS spectra were collected from SERS nanoprobes injected in pig skin ex vivo. Pig skin is considered a good model of human skin and was previously used in testing the performance of our SERS nanoprobes when implanted subcutaneously. In this study, we show the application of SERDS for background removal and signal recovery in spectra of SERS nanoprobes. In addition, the detection of SERS plasmonic nanoprobes implanted into animal skin further illustrates the usefulness of the SE‐SERDS technique and how the combination of SERS with SERDS provides a powerful tool for in vivo biosensing.

View Accepted Manuscript (Publisher)

Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0014077

OSTI ID:: 1472161

Alternate ID(s):: OSTI ID: 1612070

Journal Information:: Journal of Raman Spectroscopy, Journal Name: Journal of Raman Spectroscopy Journal Issue: 12 Vol. 49; ISSN 0377-0486

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Netherlands

Language:: English

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