Trace Analysis and Reaction Monitoring by Nanophotonic Ionization Mass Spectrometry from Elevated Bowtie and Silicon Nanopost Arrays

A. Stopka, Sylwia; A. Holmes, Xavier; Korte, Andrew R.; R. Compton, Laine; Retterer, Scott T.; Vertes, Akos

doi:10.1002/adfm.201801730

Title: Trace Analysis and Reaction Monitoring by Nanophotonic Ionization Mass Spectrometry from Elevated Bowtie and Silicon Nanopost Arrays

Journal Article · Tue May 22 00:00:00 EDT 2018 · Advanced Functional Materials

DOI:https://doi.org/10.1002/adfm.201801730· OSTI ID:1468089

A. Stopka, Sylwia ^[1]; A. Holmes, Xavier ^[1]; Korte, Andrew R. ^[1]; R. Compton, Laine ^[1];

^[2];

^[1]

George Washington Univ., Washington, DC (United States). Department of Chemistry
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Science (CNMS) and Biosciences Division

Abstract Silicon nanopost arrays (NAPA) are used in trace analysis by mass spectrometry (MS) because they enable highly efficient ion production from small molecules and thin tissue sections by UV laser desorption ionization (LDI). Such nanophotonic ionization of adsorbates relies on localized interactions between a nanostructured substrate and laser radiation. In LDI from NAPA, only the component of the oscillating electric field vector that is parallel with the posts couples the laser energy into the nanostructure. Enhancements in control over adsorbate ionization and fragmentation are expected if the surface‐parallel component can also interact with the nanostructure. Here, an alternative nanophotonic ionization platform is introduced for LDI‐MS, the elevated bowtie (EBT) array by adding triangular chromium features on top of silicon post pairs to form bowties. Compared to NAPA, the threshold fluence for ionization from EBT is lower, and at low laser fluences the ionization efficiency is increased by a factor of ≈17. The EBT platform with optimized apex angle exhibits a higher survival yield for molecular ions produced from biomolecules and xenobiotics and allows more control over fragmentation by adjusting the fluence. These unique nanophotonic ionization attributes are utilized for trace analysis and reaction monitoring in complex biological samples.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Chemical Sciences, Geosciences, and Biosciences Division

Grant/Contract Number:: AC05-00OR22725; FG02-01ER15129; W911NF‐14‐2‐0020; FG02‐01ER15129; CNMS2013‐309

OSTI ID:: 1468089

Alternate ID(s):: OSTI ID: 1438491

Journal Information:: Advanced Functional Materials, Vol. 28, Issue 29; ISSN 1616-301X

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 30 works

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Related Subjects

36 MATERIALS SCIENCE
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
bowtie arrays
laser desorption
mass spectrometry
nanophotonic ionization
nanopost arrays