Conformational Selection as the Mechanism of Guest Binding in a Flexible Supramolecular Host

Hong, Cynthia M.; Kaphan, David M.; Bergman, Robert G.; Raymond, Kenneth N.; Toste, F. Dean

doi:10.1021/jacs.7b03812

Conformational Selection as the Mechanism of Guest Binding in a Flexible Supramolecular Host

Journal Article · Mon Jun 05 00:00:00 EDT 2017 · Journal of the American Chemical Society

DOI:https://doi.org/10.1021/jacs.7b03812· OSTI ID:1464149

Hong, Cynthia M. ^[1]; Kaphan, David M. ^[1]; Bergman, Robert G. ^[1]; Raymond, Kenneth N. ^[1]; ^[1]

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Chemical Sciences Division; Univ. of California, Berkeley, CA (United States). Dept. of Chemistry

This work offers a detailed mechanistic investigation of host-guest encapsulation behavior in a new enzyme-mimetic metal-ligand host and provides the first observation of a conformational selection mechanism (as opposed to induced fit) in a supramolecular system. The Ga₄L₄ host described features a C₃-symmetric ligand motif with meta-substituted phenyl spacers, which enables the host to initially self-assemble into an S₄-symmetric structure and then subsequently isomerize to a T-symmetric tetrahedron for better accommodation of a sufficiently large guest. Selective inversion recovery ¹H NMR studies provide structural insights into the self-exchange behaviors of the host and the guest individually in this dynamic system. Kinetic analysis of the encapsulation-isomerization event revealed that increasing the concentration of guest inhibits the rate of host-guest relaxation, a key distinguishing feature of conformational selection. A comprehensive study of this simple enzyme mimic provides insight into analogous behavior in biophysics and enzymology and aims to inform the design of efficient self-assembled microenvironment catalysts.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22). Chemical Sciences, Geosciences & Biosciences Division; National Science Foundation (NSF)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1464149

Journal Information:: Journal of the American Chemical Society, Journal Name: Journal of the American Chemical Society Journal Issue: 23 Vol. 139; ISSN 0002-7863

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

References (53)

The Self-Assembly of a Predesigned Tetrahedral M₄L₆ Supramolecular Cluster Caulder, Dana L.; Powers, Ryan E.; Parac, Tatjana N. Angewandte Chemie International Edition, Vol. 37, Issue 13-14, p. 1840-1843 https://doi.org/10.1002/(SICI)1521-3773(19980803)37:13/14<1840::AID-ANIE1840>3.0.CO;2-D	journal	August 1998
Triple Helicate—Tetrahedral Cluster Interconversion Controlled by Host-Guest Interactions Scherer, Markus; Caulder, Dana L.; Johnson, Darren W. Angewandte Chemie International Edition, Vol. 38, Issue 11 https://doi.org/10.1002/(SICI)1521-3773(19990601)38:11<1587::AID-ANIE1587>3.0.CO;2-R	journal	June 1999
Induced-Fit Molecular Recognition with Water-Soluble Cavitands Haino, Takeharu; Rudkevich, Dmitry M.; Shivanyuk, Alexander Chemistry - A European Journal, Vol. 6, Issue 20 https://doi.org/10.1002/1521-3765(20001016)6:20<3797::AID-CHEM3797>3.0.CO;2-1	journal	October 2000
Enantiomerisation of Tetrahedral Homochiral [M4L6] Clusters: Synchronized Four Bailar Twists and Six Atropenantiomerisation Processes Monitored by Temperature-Dependent Dynamic 1H NMR Spectroscopy Chelate complexes (metalla coronates), Part 21. Part 20: R. W. Saalfrank, H. Maid, N. Mooren, F. Hampel, Angew. Chem. 2002, 113, 323–326; Angew. Chem. Int. Ed. 2002, 41, 304–307. Saalfrank, Rolf W.; Demleitner, Bernhard; Glaser, Horst Chemistry - A European Journal, Vol. 8, Issue 12 https://doi.org/10.1002/1521-3765(20020617)8:12<2679::AID-CHEM2679>3.0.CO;2-7	journal	June 2002
Enzyme-like Control of Carbocation Deprotonation Regioselectivity in Supramolecular Catalysis of the Nazarov Cyclization Hastings, Courtney J.; Backlund, Mikael P.; Bergman, Robert G. Angewandte Chemie, Vol. 123, Issue 45 https://doi.org/10.1002/ange.201105325	journal	September 2011
Allosterically Coupled Double Induced Fit for 1+1+1+1 Self-Assembly of a Calix[6]trisamine, a Calix[6]trisacid, and Their Guests Le Gac, Stéphane; Marrot, Jérôme; Reinaud, Olivia Angewandte Chemie International Edition, Vol. 45, Issue 19 https://doi.org/10.1002/anie.200503906	journal	May 2006
Functional Molecular Flasks: New Properties and Reactions within Discrete, Self-Assembled Hosts Yoshizawa, Michito; Klosterman, Jeremy K.; Fujita, Makoto Angewandte Chemie International Edition, Vol. 48, Issue 19, p. 3418-3438 https://doi.org/10.1002/anie.200805340	journal	April 2009
Induced-Fit Formation of a Tetrameric Organic Capsule Consisting of Hexagram-Shaped Amphiphile Molecules Hiraoka, Shuichi; Harano, Koji; Nakamura, Takashi Angewandte Chemie International Edition, Vol. 48, Issue 38 https://doi.org/10.1002/anie.200902652	journal	September 2009
Enzyme Mimics Based Upon Supramolecular Coordination Chemistry Wiester, Michael J.; Ulmann, Pirmin A.; Mirkin, Chad A. Angewandte Chemie International Edition, Vol. 50, Issue 1 https://doi.org/10.1002/anie.201000380	journal	October 2010
“Induced Fit” in Chiral Recognition: Epimerization upon Dimerization in the Hierarchical Self‐Assembly of Helicate‐type Titanium(IV) Complexes Albrecht, Markus; Isaak, Elisabeth; Baumert, Miriam Angewandte Chemie International Edition, Vol. 50, Issue 12 https://doi.org/10.1002/anie.201006448	journal	March 2011
Einfluss der Configuration auf die Wirkung der Enzyme Fischer, Emil Berichte der deutschen chemischen Gesellschaft, Vol. 27, Issue 3 https://doi.org/10.1002/cber.18940270364	journal	October 1894
Fluorescent ‘Twist-on’ Sensing by Induced-Fit Anion Stabilisation of a Planar Chromophore Swinburne, Adam N.; Paterson, Martin J.; Beeby, Andrew Chemistry - A European Journal, Vol. 16, Issue 9 https://doi.org/10.1002/chem.200903293	journal	February 2010
Hydrophobic Chemistry in Aqueous Solution: Stabilization and Stereoselective Encapsulation of Phosphonium Guests in a Supramolecular Host Brumaghim, Julia�L.; Michels, Martin; Raymond, Kenneth�N. European Journal of Organic Chemistry, Vol. 2004, Issue 22 https://doi.org/10.1002/ejoc.200400428	journal	November 2004
On the nature of allosteric transitions: A plausible model Monod, Jacque; Wyman, Jeffries; Changeux, Jean-Pierre Journal of Molecular Biology, Vol. 12, Issue 1 https://doi.org/10.1016/S0022-2836(65)80285-6	journal	May 1965
Guest-induced conformational change in a flexible host: mono-altro-β-cyclodextrin Fujita, Kahee; Chen, Wen-Hua; Yuan, De-Qi Tetrahedron: Asymmetry, Vol. 10, Issue 9 https://doi.org/10.1016/S0957-4166(99)00127-5	journal	May 1999
Characterization of self-assembled supramolecular [Ga4L6] host-guest complexes by electrospray ionization mass spectrometry Andersen, Ulla N.; Seeber, Georg; Fiedler, Dorothea Journal of the American Society for Mass Spectrometry, Vol. 17, Issue 3 https://doi.org/10.1016/j.jasms.2005.10.011	journal	March 2006
Conformational selection in trypsin-like proteases Pozzi, Nicola; Vogt, Austin D.; Gohara, David W. Current Opinion in Structural Biology, Vol. 22, Issue 4 https://doi.org/10.1016/j.sbi.2012.05.006	journal	August 2012
Conformation Coupled Enzyme Catalysis: Single-Molecule and Transient Kinetics Investigation of Dihydrofolate Reductase ^† Antikainen, Nina M.; Smiley, R. Derike; Benkovic, Stephen J. Biochemistry, Vol. 44, Issue 51 https://doi.org/10.1021/bi051378i	journal	December 2005
Conformational Selection or Induced Fit? A Critical Appraisal of the Kinetic Mechanism Vogt, Austin D.; Di Cera, Enrico Biochemistry, Vol. 51, Issue 30 https://doi.org/10.1021/bi3006913	journal	July 2012
Conformational Selection Is a Dominant Mechanism of Ligand Binding Vogt, Austin D.; Di Cera, Enrico Biochemistry, Vol. 52, Issue 34 https://doi.org/10.1021/bi400929b	journal	August 2013
Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function Tummino, Peter J.; Copeland, Robert A. Biochemistry, Vol. 47, Issue 20 https://doi.org/10.1021/bi8002023	journal	May 2008
Supramolecular Catalysis in Metal–Ligand Cluster Hosts Brown, Casey J.; Toste, F. Dean; Bergman, Robert G. Chemical Reviews, Vol. 115, Issue 9 https://doi.org/10.1021/cr4001226	journal	April 2015
Large M ₄ L ₄ (M = Al(III), Ga(III), In(III), Ti(IV)) Tetrahedral Coordination Cages: an Extension of Symmetry-Based Design Yeh, Robert M.; Xu, Jide; Seeber, Georg Inorganic Chemistry, Vol. 44, Issue 18 https://doi.org/10.1021/ic0505145	journal	September 2005
Structural Consequences of Anionic Host−Cationic Guest Interactions in a Supramolecular Assembly Pluth, Michael D.; Johnson, Darren W.; Szigethy, Géza Inorganic Chemistry, Vol. 48, Issue 1 https://doi.org/10.1021/ic8012848	journal	January 2009
Thermodynamics of induced-fit binding inside polymacrocyclic porphyrin hosts Anderson, Harry L.; Hunter, Christopher A.; Meah, M. Nafees Journal of the American Chemical Society, Vol. 112, Issue 15 https://doi.org/10.1021/ja00171a017	journal	July 1990
Guest Exchange Dynamics in an M₄L₆ Tetrahedral Host Davis, Anna V.; Fiedler, Dorothea; Seeber, Georg Journal of the American Chemical Society, Vol. 128, Issue 4 https://doi.org/10.1021/ja056556+	journal	January 2006
Making Amines Strong Bases: Thermodynamic Stabilization of Protonated Guests in a Highly-Charged Supramolecular Host ¹ Pluth, Michael D.; Bergman, Robert G.; Raymond, Kenneth N. Journal of the American Chemical Society, Vol. 129, Issue 37 https://doi.org/10.1021/ja072654e	journal	September 2007
Controlling the Transmission of Stereochemical Information through Space in Terphenyl-Edged Fe ₄ L ₆ Cages Meng, Wenjing; Clegg, Jack K.; Thoburn, John D. Journal of the American Chemical Society, Vol. 133, Issue 34 https://doi.org/10.1021/ja205254s	journal	August 2011
Selective Monoterpene-like Cyclization Reactions Achieved by Water Exclusion from Reactive Intermediates in a Supramolecular Catalyst Hart-Cooper, William M.; Clary, Kristen N.; Toste, F. Dean Journal of the American Chemical Society, Vol. 134, Issue 43 https://doi.org/10.1021/ja308254k	journal	October 2012
Giant Electroactive M ₄ L ₆ Tetrahedral Host Self-Assembled with Fe(II) Vertices and Perylene Bisimide Dye Edges Mahata, Kingsuk; Frischmann, Peter D.; Würthner, Frank Journal of the American Chemical Society, Vol. 135, Issue 41 https://doi.org/10.1021/ja4083039	journal	October 2013
Chiral Amide Directed Assembly of a Diastereo- and Enantiopure Supramolecular Host and its Application to Enantioselective Catalysis of Neutral Substrates Zhao, Chen; Sun, Qing-Fu; Hart-Cooper, William M. Journal of the American Chemical Society, Vol. 135, Issue 50 https://doi.org/10.1021/ja411631v	journal	December 2013
Mutual Induced Fit in a Synthetic Host–Guest System Sawada, Tomohisa; Hisada, Hayato; Fujita, Makoto Journal of the American Chemical Society, Vol. 136, Issue 12 https://doi.org/10.1021/ja500376x	journal	March 2014
Nucleophilic Substitution Catalyzed by a Supramolecular Cavity Proceeds with Retention of Absolute Stereochemistry Zhao, Chen; Toste, F. Dean; Raymond, Kenneth N. Journal of the American Chemical Society, Vol. 136, Issue 41 https://doi.org/10.1021/ja508799p	journal	October 2014
Gallium(III) Catecholate Complexes as Probes for the Kinetics and Mechanism of Inversion and Isomerization of Siderophore Complexes ¹ Kersting, Berthold; Telford, Jason R.; Meyer, Michel Journal of the American Chemical Society, Vol. 118, Issue 24 https://doi.org/10.1021/ja953545f	journal	January 1996
Dinuclear Catecholate Helicates: Their Inversion Mechanism Kersting, Berthold; Meyer, Michel; Powers, Ryan E. Journal of the American Chemical Society, Vol. 118, Issue 30 https://doi.org/10.1021/ja9613522	journal	January 1996
Dynamic Isomerization of a Supramolecular Tetrahedral M ₄ L ₆ Cluster ¹ Beissel, Thomas; Powers, Ryan E.; Parac, Tatjana N. Journal of the American Chemical Society, Vol. 121, Issue 17 https://doi.org/10.1021/ja984046s	journal	May 1999
Enabling New Modes of Reactivity via Constrictive Binding in a Supramolecular-Assembly-Catalyzed Aza-Prins Cyclization Kaphan, David M.; Toste, F. Dean; Bergman, Robert G. Journal of the American Chemical Society, Vol. 137, Issue 29 https://doi.org/10.1021/jacs.5b01261	journal	July 2015
Molecular Recognition Study on Supramolecular Systems. 20. Molecular Recognition and Enantioselectivity of Aliphatic Alcohols by l -Tryptophan-Modified β-Cyclodextrin Liu, Yu; Han, Bao-Hang; Sun, Shi-Xin The Journal of Organic Chemistry, Vol. 64, Issue 5 https://doi.org/10.1021/jo981891k	journal	March 1999
Stereochemical plasticity modulates cooperative binding in a CoII12L6 cuboctahedron Rizzuto, Felix J.; Nitschke, Jonathan R. Nature Chemistry, Vol. 9, Issue 9 https://doi.org/10.1038/nchem.2758	journal	April 2017
The role of dynamic conformational ensembles in biomolecular recognition Boehr, David D.; Nussinov, Ruth; Wright, Peter E. Nature Chemical Biology, Vol. 5, Issue 11 https://doi.org/10.1038/nchembio.232	journal	October 2009
Supramolecular catalysis. Part 2: artificial enzyme mimics Raynal, Matthieu; Ballester, Pablo; Vidal-Ferran, Anton Chem. Soc. Rev., Vol. 43, Issue 5 https://doi.org/10.1039/C3CS60037H	journal	January 2014
The effect of host structure on the selectivity and mechanism of supramolecular catalysis of Prins cyclizations Hart-Cooper, William M.; Zhao, Chen; Triano, Rebecca M. Chemical Science, Vol. 6, Issue 2 https://doi.org/10.1039/C4SC02735C	journal	January 2015
Catenation and encapsulation induce distinct reconstitutions within a dynamic library of mixed-ligand Zn ₄ L ₆ cages Black, Samuel P.; Wood, Daniel M.; Schwarz, Felix B. Chemical Science, Vol. 7, Issue 4 https://doi.org/10.1039/C5SC04906G	journal	January 2016
Escherichia coli alkaline phosphatase. An analysis of transient kinetics Halford, S. E. Biochemical Journal, Vol. 125, Issue 1 https://doi.org/10.1042/bj1250319	journal	November 1971
Self-Assembled Supramolecular Structures as Catalysts for Reactions Involving Cationic Transition States Catti, Lorenzo; Zhang, Qi; Tiefenbacher, Konrad Synthesis, Vol. 48, Issue 03 https://doi.org/10.1055/s-0035-1560362	journal	November 2015
Protein-like proton exchange in a synthetic host cavity Hart-Cooper, William M.; Sgarlata, Carmelo; Perrin, Charles L. Proceedings of the National Academy of Sciences, Vol. 112, Issue 50 https://doi.org/10.1073/pnas.1515639112	journal	November 2015
Application of a Theory of Enzyme Specificity to Protein Synthesis Koshland, D. E. Proceedings of the National Academy of Sciences, Vol. 44, Issue 2 https://doi.org/10.1073/pnas.44.2.98	journal	February 1958
Single-molecule fluorescence spectroscopy of enzyme conformational dynamics and cleavage mechanism Ha, T.; Ting, A. Y.; Liang, J. Proceedings of the National Academy of Sciences, Vol. 96, Issue 3 https://doi.org/10.1073/pnas.96.3.893	journal	February 1999
Selective-inversion experiments applied to chemical exchange in coupled spin systems Bain, Alex D.; Fletcher, D. A. Molecular Physics, Vol. 95, Issue 6 https://doi.org/10.1080/00268979809483241	journal	December 1998
Enzyme Dynamics During Catalysis Eisenmesser, E. Z. Science, Vol. 295, Issue 5559 https://doi.org/10.1126/science.1066176	journal	February 2002
Acid Catalysis in Basic Solution: A Supramolecular Host Promotes Orthoformate Hydrolysis Pluth, M. D.; Bergman, R. G.; Raymond, K. N. Science, Vol. 316, Issue 5821 https://doi.org/10.1126/science.1138748	journal	April 2007
A supramolecular microenvironment strategy for transition metal catalysis Kaphan, D. M.; Levin, M. D.; Bergman, R. G. Science, Vol. 350, Issue 6265 https://doi.org/10.1126/science.aad3087	journal	December 2015
Conformational selection or induced-fit? 50 years of debate resolved Changeux, Jean-Pierre; Edelstein, Stuart F1000 Biology Reports, Vol. 3 https://doi.org/10.3410/B3-19	journal	September 2011

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