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Efficient Computational Modeling of Human Ventricular Activation and Its Electrocardiographic Representation: A Sensitivity Study

Journal Article · · Cardiovascular Engineering and Technology
 [1];  [1];  [2];  [3];  [1];  [4];  [1];  [1];  [1];  [1];  [2];  [5];  [1];  [1]
  1. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
  2. Univ. of California, San Diego, CA (United States)
  3. Univ. of California, Davis, CA (United States)
  4. Harvard Medical School, Boston, MA (United States); Brigham and Women’s Hospital, Boston, MA (United States)
  5. Univ. of California, San Diego, CA (United States); VA San Diego Healthcare System, San Diego, CA (United States)
+ Show Author Affiliations
Patient-specific models of the ventricular myocardium, combined with the computational power to run rapid simulations, are approaching the level where they could be used for personalized cardiovascular medicine. A major remaining challenge is determining model parameters from available patient data, especially for models of the Purkinje-myocardial junctions (PMJs): the sites of initial ventricular electrical activation. There are no non-invasive methods for localizing PMJs in patients, and the relationship between the standard clinical ECG and PMJ model parameters is underexplored. Thus, this study aimed to determine the sensitivity of the QRS complex of the ECG to the anatomical location and regional number of PMJs. The QRS complex was simulated using an image-based human torso and biventricular model, and cardiac electrophysiology was simulated using Cardioid. The PMJs were modeled as discrete current injection stimuli, and the location and number of stimuli were varied within initial activation regions based on published experiments. Results indicate that the QRS complex features were most sensitive to the presence or absence of four “seed” stimuli, and adjusting locations of nearby “regional” stimuli provided finer tuning. Decreasing number of regional stimuli by an order of magnitude resulted in virtually no change in the QRS complex. Thus, a minimal 12-stimuli configuration was identified that resulted in physiological excitation, defined by QRS complex feature metrics and ventricular excitation pattern. In conclusion, overall, the sensitivity results suggest that parameterizing PMJ location, rather than number, be given significantly higher priority in future studies creating personalized ventricular models from patient-derived ECGs.
Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
National Institutes of Health (NIH); USDOE
Grant/Contract Number:
AC05-00OR22725; AC52-07NA27344; FG02-97ER25308
OSTI ID:
1463971
Journal Information:
Cardiovascular Engineering and Technology, Journal Name: Cardiovascular Engineering and Technology Journal Issue: 3 Vol. 9; ISSN 1869-408X
Publisher:
Springer NatureCopyright Statement
Country of Publication:
United States
Language:
English

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  • Mirin, Arthur A.; Richards, David F.; Glosli, James N.
  • 2012 SC - International Conference for High Performance Computing, Networking, Storage and Analysis, 2012 International Conference for High Performance Computing, Networking, Storage and Analysis https://doi.org/10.1109/SC.2012.108
conference November 2012
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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
97 MATHEMATICS AND COMPUTING
Bundle branch block
Computational electrophysiology
Electrocardiogram
Human ventricular excitation
Patient-specific modeling
Sensitivity analysis