Next-generation in vivo optical imaging with short-wave infrared quantum dots

Bruns, Oliver T.; Bischof, Thomas S.; Harris, Daniel K.; Franke, Daniel; Shi, Yanxiang; Riedemann, Lars; Bartelt, Alexander; Jaworski, Frank B.; Carr, Jessica A.; Rowlands, Christopher J.; Wilson, Mark W.  B.; Chen, Ou; Wei, He; Hwang, Gyu Weon; Montana, Daniel M.; Coropceanu, Igor; Achorn, Odin B.; Kloepper, Jonas; Heeren, Joerg; So, Peter T.  C.; Fukumura, Dai; Jensen, Klavs F.; Jain, Rakesh K.; Bawendi, Moungi G.

doi:10.1038/s41551-017-0056

Next-generation in vivo optical imaging with short-wave infrared quantum dots

Journal Article · Mon Apr 10 00:00:00 EDT 2017 · Nature Biomedical Engineering (Online)

DOI:https://doi.org/10.1038/s41551-017-0056· OSTI ID:1463094

^[1]; ^[2]; Harris, Daniel K. ^[3]; Franke, Daniel ^[2]; Shi, Yanxiang ^[4]; Riedemann, Lars ^[5]; Bartelt, Alexander ^[6]; Jaworski, Frank B. ^[7]; ^[2]; Rowlands, Christopher J. ^[8]; ^[9]; Chen, Ou ^[10]; Wei, He ^[2]; ^[11]; Montana, Daniel M. ^[3]; Coropceanu, Igor ^[2]; Achorn, Odin B. ^[2]; Kloepper, Jonas ^[12]; ^[13]; So, Peter T. C. ^[14] more »

Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Chemistry; OSTI
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Chemistry
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Chemistry and Dept. of Materials Science and Engineering
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Chemical Engineering
Harvard Medical School and Massachusetts General Hospital, Cambridge, MA (United States). Edwin L. Steele Lab. for Tumor Biology; Heidelberg Univ. (Germany). Univ. Hospital Heidelberg and Neurology Clinic and National Center for Tumor Diseases; German Cancer Research Center (DKFZ), Heidelberg (Germany). German Cancer Consortium and Clinical Cooperation Unit Neuro-Oncology
Harvard Univ., Cambridge, MA (United States). Harvard T.H. Chan School of Public Health, Sabri Ulker Center and Dept. of Genetics and Complex Diseases
Raytheon Vision Systems, Goleta, CA (United States)
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Biological Engineering
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Chemistry; Univ. of Toronto, ON (Canada). Dept. of Chemistry
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Chemistry; Brown Univ., Providence, RI (United States). Dept. of Chemistry
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Chemistry and Dept. of Materials Science and Engineering; Korea Inst. of Science and Technology, Seoul (Korea, Republic of)
Harvard Medical School and Massachusetts General Hospital, Cambridge, MA (United States). Edwin L. Steele Lab. for Tumor Biology; Univ. of Lausanne (Switzerland). Vaud Univ. Hospital Center (CHUV) and Dept. of Internal Medicine
Univ. of Hamburg (Germany). Univ. Medical Center Hamburg-Eppendorf (UKE) and Dept. of Biochemistry and Molecular Cell Biology
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Biological Engineering and Dept. of Mechanical Engineering
Harvard Medical School and Massachusetts General Hospital, Cambridge, MA (United States). Edwin L. Steele Lab. for Tumor Biology

For in vivo imaging, the short-wavelength infrared region (SWIR; 1,000–2,000 nm) provides several advantages over the visible and near-infrared regions: general lack of autofluorescence, low light absorption by blood and tissue, and reduced scattering. However, the lack of versatile and functional SWIR emitters has prevented the general adoption of SWIR imaging by the biomedical research community. In this work, we introduce a class of high-quality SWIR-emissive indium-arsenide-based quantum dots that are readily modifiable for various functional imaging applications, and that exhibit narrow and size-tunable emission and a dramatically higher emission quantum yield than previously described SWIR probes. To demonstrate the unprecedented combination of deep penetration, high spatial resolution, multicolour imaging and fast acquisition speed afforded by the SWIR quantum dots, we quantified, in mice, the metabolic turnover rates of lipoproteins in several organs simultaneously and in real time as well as heartbeat and breathing rates in awake and unrestrained animals, and generated detailed three-dimensional quantitative flow maps of the mouse brain vasculature.

View Accepted Manuscript (DOE)

Research Organization:: Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

Sponsoring Organization:: Boehringer Ingelheim Fonds (BIF); European Molecular Biology Organization (EMBO); Evonik Foundation; German Cancer Aid; German Research Foundation (DFG); Hamamatsu Photonics (Japan); Leducq Foundation; Massachusetts General Hospital, Boston, MA (United States); National Foundation for Cancer Research (NFCR); National Inst. of Health (NIH); National Science Foundation (NSF); SAMSUNG Global Research Outreach (GRO) Program; Solidar-Immun Foundation; US Army Research Office (ARO); USDOD; USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

Grant/Contract Number:: SC0001088

OSTI ID:: 1463094

Alternate ID(s):: OSTI ID: 1388341

Journal Information:: Nature Biomedical Engineering (Online), Journal Name: Nature Biomedical Engineering (Online) Journal Issue: 4 Vol. 1; ISSN 2157-846X

Country of Publication:: United States

Language:: English

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NIR-II fluorescence microscopic imaging of cortical vasculature in non-human primates Cai, Zhaochong; Zhu, Liang; Wang, Mengqi Theranostics, Vol. 10, Issue 9 https://doi.org/10.7150/thno.43533	journal	January 2020

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