Rotaxane probes for protease detection by 129Xe hyperCEST NMR

Slack, Clancy C.; Finbloom, Joel A.; Jeong, Keunhong; Bruns, Carson J.; Wemmer, David E.; Pines, Alexander; Francis, Matthew B.

doi:10.1039/c6cc09302g

Rotaxane probes for protease detection by ¹²⁹Xe hyperCEST NMR

Journal Article · Thu Dec 15 04:00:00 EST 2016 · ChemComm

DOI:https://doi.org/10.1039/c6cc09302g· OSTI ID:1437955

^[1]; ^[2]; Jeong, Keunhong ^[1]; Bruns, Carson J. ^[2]; Wemmer, David E. ^[3]; Pines, Alexander ^[1]; ^[1]

Univ. of California, Berkeley, CA (United States). Department of Chemistry; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
Univ. of California, Berkeley, CA (United States). Department of Chemistry
Univ. of California, Berkeley, CA (United States). Department of Chemistry; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Physical Biosciences Division

In this work, we report a CB6 rotaxane for the ¹²⁹Xe hyperCEST NMR detection of matrix metalloprotease 2 (MMP-2) activity. MMP-2 is overexpressed in cancer tissue, and hence is a cancer marker. A peptide containing an MMP-2 recognition sequence was incorporated into the rotaxane, synthesized via CB6-promoted click chemistry. Upon cleavage of the rotaxane by MMP-2, CB6 became accessible for ¹²⁹Xe@CB6 interactions, leading to protease-responsive hyperCEST activation.

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

DOE Contract Number:: AC02-05CH11231

OSTI ID:: 1437955

Journal Information:: ChemComm, Journal Name: ChemComm Journal Issue: 6 Vol. 53; ISSN CHCOFS; ISSN 1359-7345

Publisher:: Royal Society of Chemistry

Country of Publication:: United States

Language:: English

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