Targeted Molecular Imaging of Cancer Cells Using MS2-Based 129 Xe NMR

Jeong, Keunhong; Netirojjanakul, Chawita; Munch, Henrik K.; Sun, Jinny; Finbloom, Joel A.; Wemmer, David E.; Pines, Alexander; Francis, Matthew B.

doi:10.1021/acs.bioconjchem.6b00275

Targeted Molecular Imaging of Cancer Cells Using MS2-Based ¹²⁹ Xe NMR

Journal Article · Mon Jul 25 00:00:00 EDT 2016 · Bioconjugate Chemistry

DOI:https://doi.org/10.1021/acs.bioconjchem.6b00275· OSTI ID:1378338

Jeong, Keunhong ^[1]; Netirojjanakul, Chawita ^[2]; Munch, Henrik K. ^[2]; Sun, Jinny ^[2]; Finbloom, Joel A. ^[2]; Wemmer, David E. ^[3]; Pines, Alexander ^[1]; Francis, Matthew B. ^[1]

Univ. of California, Berkeley, CA (United States). Dept. of Chemistry; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
Univ. of California, Berkeley, CA (United States). Dept. of Chemistry
Univ. of California, Berkeley, CA (United States). Dept. of Chemistry; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Physical Biosciences Division

Targeted, selective, and highly sensitive ¹²⁹Xe NMR nanoscale biosensors have been synthesized using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized ¹²⁹Xe NMR signal contrast and hyper-CEST ¹²⁹Xe MRI image contrast indicated its promise as highly sensitive hyperpolarized ¹²⁹Xe NMR nanoscale biosensor for future applications in cancer detection in vivo.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE Office of Science (SC), Fusion Energy Sciences (FES) (SC-24)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1378338

Journal Information:: Bioconjugate Chemistry, Journal Name: Bioconjugate Chemistry Journal Issue: 8 Vol. 27; ISSN 1043-1802

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited By (1)

Nanoparticle-Based Contrast Agents for ¹²⁹ Xe HyperCEST NMR and MRI Applications Jayapaul, Jabadurai; Schröder, Leif Contrast Media & Molecular Imaging, Vol. 2019 https://doi.org/10.1155/2019/9498173	journal	November 2019

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