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High throughput DNA damage quantification of human tissue with home-based collection device

Patent ·
OSTI ID:1433377
Kits, methods and systems for providing a service to provide a subject with information regarding the state of a subject's DNA damage. Collection, processing and analysis of samples are also described.
Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
9,931,634
Application Number:
14/634,266
OSTI ID:
1433377
Country of Publication:
United States
Language:
English

References (44)

A portable microfluidic fluorescence spectrometer device for γ-H2AX-based biological dosimetry journal September 2011
Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair journal March 2011
Image-Based Modeling Reveals Dynamic Redistribution of DNA Damage into Nuclear Sub-Domains journal January 2007
Imaging Features that Discriminate between Foci Induced by High- and Low-LET Radiation in Human Fibroblasts journal May 2006
Insight into sites journal November 1996
Radial Cutoff LET and Radial Cutoff Dose Calculations for Heavy Charged Particles in Water journal June 1973
DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139 journal March 1998
Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization journal April 2010
Locations of radiation-produced DNA double strand breaks along chromosomes: a stochastic cluster process formalism journal July 1999
Induction and quantification of γ-H2AX foci following low and high LET-irradiation journal January 2006
Computational modelling of low-energy electron-induced DNA damage by early physical and chemical events journal January 1997
Measurement of Prompt DNA Double-Strand Breaks in Mammalian Cells without Including Heat-Labile Sites: Results for Cells Deficient in Nonhomologous End Joining journal April 2003
Radiological Physics Characteristics of the Extracted Heavy Ion Beams of the Bevatron journal December 1971
DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin journal April 2011
Effect of Linear Energy Transfer (LET) on the Complexity of α-Particle-Induced Chromosome Aberrations in Human CD34+ Cells journal May 2007
Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells journal December 2011
Computational Methods for Analysis of Foci: Validation for Radiation-Induced γ-H2AX Foci in Human Cells journal January 2006
Live cell microscopy analysis of radiation-induced DNA double-strand break motion journal February 2009
Review: Proximity effects in the production of chromosome aberrations by ionizing radiation journal January 1997
Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains journal January 2004
Stochastic properties of radiation-induced DSB: DSB distributions in large scale chromatin loops, the HPRT gene and within the visible volumes of DNA repair foci journal January 2008
Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM journal December 2004
Positional Stability of Damaged Chromatin Domains along Radiation Tracks in Mammalian Cells journal April 2009
Quantitative Image Analysis of Laminin Immunoreactivity in Skin Basement Membrane Irradiated with 1 GeV/nucleon Iron Particles journal October 2000
Microfluidic Isolation of Leukocytes from Whole Blood for Phenotype and Gene Expression Analysis journal August 2006
M-FISH analysis shows that complex chromosome aberrations induced by α-particle tracks are cumulative products of localized rearrangements journal August 2002
Estimating radiation-induced cancer risks at very low doses: rationale for using a linear no-threshold approach journal February 2006
Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre journal May 2003
Repair of Radiation-Induced Heat-Labile Sites is Independent of DNA-PKcs, XRCC1 and PARP journal May 2008
Histone H2AX phosphorylation in response to changes in chromatin structure induced by altered osmolarity journal November 2008
Computational Approach for Determining the Spectrum of DNA Damage Induced by Ionizing Radiation journal November 2001
Radiation chemistry of heavy-particle tracks. 1. General considerations journal December 1980
Reflections and meditations upon complex chromosomal exchanges journal December 2002
Spatial Dynamics of DNA Damage Response Protein Foci along the Ion Trajectory of High-LET Particles journal December 2011
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation journal January 2003
Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation journal January 2010
Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group journal April 2001
Extraction of spots in biological images using multiscale products journal September 2002
Comparison of the induction and disappearance of DNA double strand breaks and γ-H2AX foci after irradiation of chromosomes in G1-phase or in condensed metaphase cells journal March 2008
Large-Mutation Spectra Induced at Hemizygous Loci by Low-LET Radiation: Evidence for Intrachromosomal Proximity Effects journal November 2001
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses journal April 2003
DNA-repair protein distribution along the tracks of energetic ions journal November 2006
Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X‐rays journal May 2003
Cellular responses to DNA double-strand breaks after low-dose γ-irradiation journal April 2009

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