High throughput DNA damage quantification of human tissue with home-based collection device

Costes, Sylvain V.; Tang, Jonathan; Yannone, Steven M.

Title: High throughput DNA damage quantification of human tissue with home-based collection device

Patent · Tue Apr 03 00:00:00 EDT 2018

OSTI ID:1433377

Costes, Sylvain V.; Tang, Jonathan; Yannone, Steven M.

Kits, methods and systems for providing a service to provide a subject with information regarding the state of a subject's DNA damage. Collection, processing and analysis of samples are also described.

View Patent

Cite

Export

Save

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 9,931,634

Application Number:: 14/634,266

OSTI ID:: 1433377

Resource Relation:: Patent File Date: 2015 Feb 27

Country of Publication:: United States

Language:: English

References (46)

Method and kit for making injections and withdrawing blood without the use of protective gloves Watson, Robert L. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6502699 US Patent Document 6,502,699	patent	January 2003
Systems and methods for robotic transport Zhang, Jian; Salerno, Alessio; Simaan, Nabil https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7787681 US Patent Document 7,787,681	patent	August 2010
Cold emitter x-ray tube incorporating a nanostructured carbon film electron emitter Espinosa, Robert J.; Boyer, Bradley W.; Snyder, Scott https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030002627 US Patent Application 10/224008; 20030002627	patent-application	January 2003
Specimen collecting, processing and analytical assembly Karmali, Rashida A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050232813 US Patent Application 10/826083; 20050232813	patent-application	October 2005
Method for determination and quantification of radiation or genotoxin exposure D'Andrea, Alan D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050255502 US Patent Application 11/046346; 20050255502	patent-application	November 2005
Reactor systems having a light-interacting component Miller, Scott E.; LeBlanc, Sean J.; Rodgers, Seth T. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070099292 US Patent Application 11/584343; 20070099292	patent-application	May 2007
Methods for Detecting DNA Damage and Screening for Cancer Therapeutics Halazonetis, Thomas; Schultz, Linda B. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070178044 US Patent Application 11/695733; 20070178044	patent-application	August 2007
Devices, systems and methods for the collection, stimulation, stabilization, and analysis of a biological sample Hale, Matthew https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090155838 US Patent Application 12/315186; 20090155838	patent-application	June 2009
Method For Determination And Quantification Of Radiation Or Genotoxin Exposure D'Andrea, Alan D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110312514 US Patent Application 13/023201; 20110312514	patent-application	December 2011
System, Devices, and Methods for Bodily Fluid Sample Transport Holmes, Elizabeth A.; Lui, Clarissa; Chen, Michael https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20140171829 US Patent Application 14/098177; 20140171829	patent-application	June 2014
Stabilization and Isolation of Extracellular Nucleic Acids Horlitz, Martin; Schubert, Anabelle; Sprenger-Haussels, Markus https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20140227687 US Patent Application 14/347048; 20140227687	patent-application	August 2014
Devices and Methods for Determining Sensitivity to Radiation Costes, Sylyain V.; Gomez-Sjoberg, Rafael; Yannone, Steven M. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20150017092 US Patent Application 14/378617; 20150017092	patent-application	January 2015
Effect of Linear Energy Transfer (LET) on the Complexity of α-Particle-Induced Chromosome Aberrations in Human CD34⁺ Cells Anderson, Rhona M.; Stevens, David L.; Sumption, Natalia D. Radiation Research, Vol. 167, Issue 5, p. 541-550 https://doi.org/10.1667/RR0813.1	journal	May 2007
M-FISH analysis shows that complex chromosome aberrations induced by α-particle tracks are cumulative products of localized rearrangements Anderson, R. M.; Stevens, D. L.; Goodhead, D. T. Proceedings of the National Academy of Sciences, Vol. 99, Issue 19, p. 12167-12172 https://doi.org/10.1073/pnas.182426799	journal	August 2002
Cellular responses to DNA double-strand breaks after low-dose γ-irradiation Asaithamby, Aroumougame; Chen, David J. Nucleic Acids Research, Vol. 37, Issue 12, p. 3912-3923 https://doi.org/10.1093/nar/gkp237	journal	April 2009
Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains Aten, Jacob A.; Stap, Jan; Krawczyk, Przemek M. Science, Vol. 303, Issue 5654, p. 92-95 https://doi.org/10.1126/science.1088845	journal	January 2004
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation Bakkenist, Christopher J.; Kastan, Michael B. Nature, Vol. 421, Issue 6922, p. 499-506 https://doi.org/10.1038/nature01368	journal	January 2003
Histone H2AX phosphorylation in response to changes in chromatin structure induced by altered osmolarity Baure, J.; Izadi, A.; Suarez, V. Mutagenesis, Vol. 24, Issue 2, p. 161-167 https://doi.org/10.1093/mutage/gen064	journal	November 2008
Estimating radiation-induced cancer risks at very low doses: rationale for using a linear no-threshold approach Brenner, David J.; Sachs, Rainer K. Radiation and Environmental Biophysics, Vol. 44, Issue 4, p. 253-256 https://doi.org/10.1007/s00411-006-0029-4	journal	February 2006
Radial Cutoff LET and Radial Cutoff Dose Calculations for Heavy Charged Particles in Water Chatterjee, A.; MacCabee, H. D.; Tobias, C. A. Radiation Research, Vol. 54, Issue 3, p. 479-494 https://doi.org/10.2307/3573740	journal	June 1973
Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair Chiolo, Irene; Minoda, Aki; Colmenares, Serafin U. Cell, Vol. 144, Issue 5, p. 732-744 https://doi.org/10.1016/j.cell.2011.02.012	journal	March 2011
Large-Mutation Spectra Induced at Hemizygous Loci by Low-LET Radiation: Evidence for Intrachromosomal Proximity Effects Costes, S.; Sachs, R.; Hlatky, L. Radiation Research, Vol. 156, Issue 5, p. 545-557 https://doi.org/10.1667/0033-7587(2001)156[0545:LMSIAH]2.0.CO;2	journal	November 2001
DNA-repair protein distribution along the tracks of energetic ions Hauptner, A.; Krücken, R.; Greubel, C. Radiation Protection Dosimetry, Vol. 122, Issue 1-4, p. 147-149 https://doi.org/10.1093/rpd/ncl420	journal	November 2006
DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin Jakob, Burkhard; Splinter, Jörn; Conrad, Sandro Nucleic Acids Research, Vol. 39, Issue 15, p. 6489-6499 https://doi.org/10.1093/nar/gkr230	journal	April 2011
Live cell microscopy analysis of radiation-induced DNA double-strand break motion Jakob, B.; Splinter, J.; Durante, M. Proceedings of the National Academy of Sciences, Vol. 106, Issue 9, p. 3172-3177 https://doi.org/10.1073/pnas.0810987106	journal	February 2009
Repair of Radiation-Induced Heat-Labile Sites is Independent of DNA-PKcs, XRCC1 and PARP Karlsson, Karin H.; Radulescu, Irina; Rydberg, Björn Radiation Research, Vol. 169, Issue 5, p. 506-512 https://doi.org/10.1667/RR1076.1	journal	May 2008
Comparison of the induction and disappearance of DNA double strand breaks and γ-H2AX foci after irradiation of chromosomes in G1-phase or in condensed metaphase cells Kato, Takamitsu A.; Okayasu, Ryuichi; Bedford, Joel S. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 639, Issue 1-2, p. 108-112 https://doi.org/10.1016/j.mrfmmm.2007.11.006	journal	March 2008
Induction and quantification of γ-H2AX foci following low and high LET-irradiation Leatherbarrow, Emma L.; Harper, Jane V.; Cucinotta, Francis A. International Journal of Radiation Biology, Vol. 82, Issue 2, p. 111-118 https://doi.org/10.1080/09553000600599783	journal	January 2006
Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X‐rays Macphail, S. H.; BanÁth, J. P.; Yu, T. Y. International Journal of Radiation Biology, Vol. 79, Issue 5, p. 351-359 https://doi.org/10.1080/0955300032000093128	journal	May 2003
Radiation chemistry of heavy-particle tracks. 1. General considerations Magee, J. L.; Chatterjee, A. The Journal of Physical Chemistry, Vol. 84, Issue 26, p. 3529-3536 https://doi.org/10.1021/j100463a008	journal	December 1980
Computational modelling of low-energy electron-induced DNA damage by early physical and chemical events Nikjoo, H.; O'Neill, P.; Goodhead, D. T. International Journal of Radiation Biology, Vol. 71, Issue 5, p. 467-483 https://doi.org/10.1080/095530097143798	journal	January 1997
Extraction of spots in biological images using multiscale products Olivo-Marin, Jean-Christophe Pattern Recognition, Vol. 35, Issue 9, p. 1989-1996 https://doi.org/10.1016/S0031-3203(01)00127-3	journal	September 2002
Stochastic properties of radiation-induced DSB: DSB distributions in large scale chromatin loops, the HPRT gene and within the visible volumes of DNA repair foci Ponomarev, Artem L.; Costes, Sylvain V.; Cucinotta, Francis A. International Journal of Radiation Biology, Vol. 84, Issue 11, p. 916-929 https://doi.org/10.1080/09553000802499212	journal	January 2008
A portable microfluidic fluorescence spectrometer device for γ-H2AX-based biological dosimetry Pope, I. A.; Barber, P. R.; Horn, S. Radiation Measurements, Vol. 46, Issue 9, p. 907-911 https://doi.org/10.1016/j.radmeas.2011.02.004	journal	September 2011
DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139 Rogakou, Emmy P.; Pilch, Duane R.; Orr, Ann H. Journal of Biological Chemistry, Vol. 273, Issue 10, p. 5858-5868 https://doi.org/10.1074/jbc.273.10.5858	journal	March 1998
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses Rothkamm, K.; Lobrich, M. Proceedings of the National Academy of Sciences, Vol. 100, Issue 9, p. 5057-5062 https://doi.org/10.1073/pnas.0830918100	journal	April 2003
Review: Proximity effects in the production of chromosome aberrations by ionizing radiation Sachs, R. K.; Chen, A. M.; Brenner, D. J. International Journal of Radiation Biology, Vol. 71, Issue 1, p. 1-19 https://doi.org/10.1080/095530097144364	journal	January 1997
Microfluidic Isolation of Leukocytes from Whole Blood for Phenotype and Gene Expression Analysis Sethu, Palaniappan; Moldawer, Lyle L.; Mindrinos, Michael N. Analytical Chemistry, Vol. 78, Issue 15, p. 5453-5461 https://doi.org/10.1021/ac060140c	journal	August 2006
Radiological Physics Characteristics of the Extracted Heavy Ion Beams of the Bevatron Tobias, C. A.; Lyman, J. T.; Chatterjee, A. Science, Vol. 174, Issue 4014, p. 1131-1134 https://doi.org/10.1126/science.174.4014.1131	journal	December 1971
Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group Wang, Huichen; Zeng, Zhao-Chong; Bui, Tu-Anh Oncogene, Vol. 20, Issue 18, p. 2212-2224 https://doi.org/10.1038/sj.onc.1204350	journal	April 2001
Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation Wilson, Paul F.; Nham, Peter B.; Urbin, Salustra S. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 683, Issue 1-2, p. 91-97 https://doi.org/10.1016/j.mrfmmm.2009.10.013	journal	January 2010
Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization Costes, S. V.; Chiolo, I.; Pluth, J. M. Mutation Research/Reviews in Mutation Research, Vol. 704, Issue 1-3, p. 78-87 https://doi.org/10.1016/j.mrrev.2009.12.006	journal	April 2010
Image-Based Modeling Reveals Dynamic Redistribution of DNA Damage into Nuclear Sub-Domains Costes, Sylvain V.; Ponomarev, Artem; Chen, James L. PLoS Computational Biology, Vol. 3, Issue 8, Article No. e155 https://doi.org/10.1371/journal.pcbi.0030155	journal	January 2007
Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre Lisby, Michael; Mortensen, Uffe H.; Rothstein, Rodney Nature Cell Biology, Vol. 5, Issue 6, p. 572-577 https://doi.org/10.1038/ncb997	journal	May 2003
Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells Neumaier, T.; Swenson, J.; Pham, C. Proceedings of the National Academy of Sciences, Vol. 109, Issue 2, p. 443-448 https://doi.org/10.1073/pnas.1117849108	journal	December 2011
Reflections and meditations upon complex chromosomal exchanges Savage, John R. K. Mutation Research/Reviews in Mutation Research, Vol. 512, Issue 2-3, p. 93-109 https://doi.org/10.1016/S1383-5742(02)00066-2	journal	December 2002

Similar Records

Identification and quantification of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines in human urine as putative biomarkers of oxidatively induced damage to DNA

Journal Article · Fri Jun 18 00:00:00 EDT 2010 · Biochemical and Biophysical Research Communications · OSTI ID:1433377

Jaruga, Pawel; Dizdaroglu, Miral

High throughput visualization and analysis of human short tandem repeat polymorphisms (STRP`s) using an infrared based automated DNA sequencer

Journal Article · Thu Sep 01 00:00:00 EDT 1994 · American Journal of Human Genetics · OSTI ID:1433377

Jang, G Y; Gartside, B O; Brumbaugh, J A

Investigations of DNA damage induction and repair resulting from cellular exposure to high dose-rate pulsed proton beams

Journal Article · Fri Jul 26 00:00:00 EDT 2013 · AIP Conference Proceedings · OSTI ID:1433377

Renis, M.; Malfa, G.; Tomasello, B.; +6 more

Related Subjects

60 APPLIED LIFE SCIENCES

Title: High throughput DNA damage quantification of human tissue with home-based collection device

Citation Formats

References (46)

Similar Records

Related Subjects