Engineered microbes and methods for microbial oil overproduction from cellulosic materials

Stephanopoulos, Gregory; Tai, Mitchell

Engineered microbes and methods for microbial oil overproduction from cellulosic materials

Patent · Tue Jan 30 04:00:00 EST 2018

OSTI ID:1418983

Stephanopoulos, Gregory; Tai, Mitchell

The invention relates to engineering microbial cells for utilization of cellulosic materials as a carbon source, including xylose.

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Research Organization:: Massachusetts Institute of Technology, Cambridge, MA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AR0000059

Assignee:: Massachusetts Institute of Technology (Cambridge, MA)

Patent Number(s):: 9,879,248

Application Number:: 14/817,489

OSTI ID:: 1418983

Country of Publication:: United States

Language:: English

References (28)

Lipid production by Yarrowia lipolytica growing on industrial glycerol in a single-stage continuous culture Papanikolaou, Seraphim; Aggelis, George Bioresource Technology, Vol. 82, Issue 1, p. 43-49 https://doi.org/10.1016/S0960-8524(01)00149-3	journal	March 2002
Ethanol production from xylose in engineered Saccharomyces cerevisiae strains: current state and perspectives Matsushika, Akinori; Inoue, Hiroyuki; Kodaki, Tsutomu Applied Microbiology and Biotechnology, Vol. 84, Issue 1, p. 37-53 https://doi.org/10.1007/s00253-009-2101-x	journal	July 2009
Comprehensive Algorithm for Quantitative Real-Time Polymerase Chain Reaction Zhao, Sheng; Fernald, Russell D. Journal of Computational Biology, Vol. 12, Issue 8, p. 1047-1064 https://doi.org/10.1089/cmb.2005.12.1047	journal	October 2005
Single cell oil production by Yarrowia lipolytica growing on an industrial derivative of animal fat in batch cultures Papanikolaou, S.; Chevalot, I.; Komaitis, M. Applied Microbiology and Biotechnology, Vol. 58, Issue 3, p. 308-312 https://doi.org/10.1007/s00253-001-0897-0	journal	March 2002
A molecular transporter engineering approach to improving xylose catabolism in Saccharomyces cerevisiae Young, Eric M.; Comer, Austin D.; Huang, Huashu Metabolic Engineering, Vol. 14, Issue 4, p. 401-411 https://doi.org/10.1016/j.ymben.2012.03.004	journal	July 2012
Investigation of limiting metabolic steps in the utilization of xylose by recombinant Saccharomyces cerevisiae using metabolic engineering : Limiting metabolic steps in xylose utilization by Karhumaa, Kaisa; Hahn-Hägerdal, Bärbel; Gorwa-Grauslund, Marie-F. Yeast, Vol. 22, Issue 5, p. 359-368 https://doi.org/10.1002/yea.1216	journal	April 2005
Metabolic-flux and network analysis in fourteen hemiascomycetous yeasts Blank, Lars M.; Lehmbeck, Frank; Sauer, Uwe FEMS Yeast Research, Vol. 5, Issue 6-7, p. 545-558 https://doi.org/10.1016/j.femsyr.2004.09.008	journal	April 2005
Accumulation of a Cocoa-Butter-Like Lipid by Yarrowia lipolytica Cultivated on Agro-Industrial Residues Papanikolaou, Seraphim; Muniglia, Lionel; Chevalot, Isabelle Current Microbiology, Vol. 46, Issue 2, p. 124-130 https://doi.org/10.1007/s00284-002-3833-3	journal	February 2003
Induction of xylulose-5-phosphate phosphoketolase in a variety of yeasts grown ond-xylose: the key to efficient xylose metabolism Evans, Christopher Thomas; Ratledge, Colin Archives of Microbiology, Vol. 139, Issue 1, p. 48-52 https://doi.org/10.1007/BF00692711	journal	September 1984
Different effectors of dimorphism in Yarrowia lipolytica Ruiz-Herrera, José; Sentandreu, Rafael Archives of Microbiology, Vol. 178, Issue 6, p. 477-483 https://doi.org/10.1007/s00203-002-0478-3	journal	December 2002
Xylose-metabolizing Saccharomyces cerevisiae strains overexpressing the TKL1 and TAL1 genes encoding the pentose phosphate pathway enzymes transketolase and transaldolase. Walfridsson, M.; Hallborn, J.; Penttilä, M. Applied and environmental microbiology, Vol. 61, Issue 12 https://doi.org/10.1128/AEM.61.12.4184-4190.1995	journal	January 1995
Screening of yeasts for growth on crude glycerol and optimization of biomass production Taccari, Manuela; Canonico, Laura; Comitini, Francesca Bioresource Technology, Vol. 110, p. 488-495 https://doi.org/10.1016/j.biortech.2012.01.109	journal	April 2012
Increasing unsaturated fatty acid contents in Escherichia coli by coexpression of three different genes Cao, Yujin; Yang, Jianming; Xian, Mo Applied Microbiology and Biotechnology, Vol. 87, Issue 1, p. 271-280 https://doi.org/10.1007/s00253-009-2377-x	journal	February 2010
DGA1 (diacylglycerol acyltransferase gene) overexpression and leucine biosynthesis significantly increase lipid accumulation in the Δsnf2 disruptant of Saccharomyces cerevisiae Kamisaka, Yasushi; Tomita, Nao; Kimura, Kazuyoshi Biochemical Journal, Vol. 408, Issue 1, p. 61-68 https://doi.org/10.1042/BJ20070449	journal	November 2007
Transcription Analysis of Recombinant Saccharomyces cerevisiae Reveals Novel Responses to Xylose Salusjärvi, Laura; Pitkänen, Juha-Pekka; Aristidou, Aristos Applied Biochemistry and Biotechnology, Vol. 128, Issue 3, p. 237-274 https://doi.org/10.1385/ABAB:128:3:237	journal	January 2006
The Crabtree Effect and its Relation to the Petite Mutation De Deken, R. H. Microbiology, Vol. 44, Issue 2, p. 157-165 https://doi.org/10.1099/00221287-44-2-157	journal	August 1966
Physiology and genetics of the dimorphic fungus Yarrowia lipolytica Barth, Gerold; Gaillardin, Claude FEMS Microbiology Reviews, Vol. 19, Issue 4, p. 219-237 https://doi.org/10.1111/j.1574-6976.1997.tb00299.x	journal	April 1997
Engineering yeasts for xylose metabolism Jeffries, Thomas W. Current Opinion in Biotechnology, Vol. 17, Issue 3, p. 320-326 https://doi.org/10.1016/j.copbio.2006.05.008	journal	June 2006
Comparison of the xylose reductase-xylitol dehydrogenase and the xylose isomerase pathways for xylose fermentation by recombinant Saccharomyces cerevisiae Karhumaa, Kaisa; Sanchez, Rosa; Hahn-Hagerdal, Bärbel Microbial Cell Factories, Vol. 6, Issue 1, 5 p. https://doi.org/10.1186/1475-2859-6-5	journal	January 2007
Saccharomyces cerevisiae Engineered for Xylose Metabolism Exhibits a Respiratory Response Jin, Y.-S.; Laplaza, J. M.; Jeffries, T. W. Applied and Environmental Microbiology, Vol. 70, Issue 11, p. 6816-6825 https://doi.org/10.1128/AEM.70.11.6816-6825.2004	journal	November 2004
Minimal metabolic engineering of for efficient anaerobic xylose fermentation a proof of principle Kuyper, Marco; Winkler, Aaron; van Dijken, Johannes FEMS Yeast Research, Vol. 4, Issue 6, p. 655-664 https://doi.org/10.1016/j.femsyr.2004.01.003	journal	March 2004
Yarrowia lipolytica Mutants Devoid of Pyruvate Carboxylase Activity Show an Unusual Growth Phenotype Flores, Carmen-Lisset; Gancedo, Carlos Eukaryotic Cell, Vol. 4, Issue 2, p. 356-364 https://doi.org/10.1128/EC.4.2.356-364.2005	journal	February 2005
Selection of Direct Transesterification as the Preferred Method for Assay of Fatty Acid Content of Microalgae Griffiths, M. J.; van Hille, R. P.; Harrison, S. T. L. Lipids, Vol. 45, Issue 11, p. 1053-1060 https://doi.org/10.1007/s11745-010-3468-2	journal	September 2010
Lipid production from Yarrowia lipolytica Po1g grown in sugarcane bagasse hydrolysate Tsigie, Yeshitila Asteraye; Wang, Chun-Yuan; Truong, Chi-Thanh Bioresource Technology, Vol. 102, Issue 19, p. 9216-9222 https://doi.org/10.1016/j.biortech.2011.06.047	journal	October 2011
Yarrowia lipolytica as a model for bio-oil production Beopoulos, Athanasios; Cescut, Julien; Haddouche, Ramdane Progress in Lipid Research, Vol. 48, Issue 6, p. 375-387 https://doi.org/10.1016/j.plipres.2009.08.005	journal	November 2009
Toward More Efficient Protein Expression: Keep the Message Simple Kalwy, Stephan; Rance, James; Young, Robert Molecular Biotechnology, Vol. 34, Issue 2, p. 151-156 https://doi.org/10.1385/MB:34:2:151	journal	January 2006
Adaptation of the xylose fermenting yeast Saccharomyces cerevisiae F12 for improving ethanol production in different fed-batch SSF processes Tomás-Pejó, E.; Ballesteros, M.; Oliva, J. M. Journal of Industrial Microbiology & Biotechnology, Vol. 37, Issue 11, p. 1211-1220 https://doi.org/10.1007/s10295-010-0768-8	journal	June 2010
The use of Yarrowia lipolytica to reduce pollution in olive mill wastewaters Scioli, Custode; Vollaro, Lucia Water Research, Vol. 31, Issue 10, p. 2520-2524 https://doi.org/10.1016/S0043-1354(97)00083-3	journal	October 1997

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