Preparation and structural characterization of a novel monoamine monoamide bisthiol metal oxo complex with technetium(V) and rhenium(V)
Conference
·
OSTI ID:141268
- Univ. of Illinois, Urbana, IL (United States)
In connection with the interest in the preparation of technetium and rhenium labeled steroids as agents for the diagnosis and therapy of breast cancer, the authors have developed a novel monoamine monoamide bisthiol (MAMA) chelate system. Stepwise N-alkylation of S-trityl protected 2-aminoethanethiol with bromacetyl bromide gave protected MAMA ligand 1 which then underwent N-benzylation to form S,S`-bistrityl protected chelate 2. Deprotection followed by metal incorporation provided metal(V) oxo complexes 3-6 (M = Re, {sup 99}Tc). The diastereoisomers of these compounds have been separated and characterized by X-ray crystallography as well as 2D-NMR.
- OSTI ID:
- 141268
- Report Number(s):
- CONF-930304--
- Country of Publication:
- United States
- Language:
- English
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