An optimized microfabricated platform for the optical generation and detection of hyperpolarized 129Xe

Kennedy, Daniel J.; Seltzer, Scott J.; Jiménez-Martínez, Ricardo; Ring, Hattie L.; Malecek, Nicolas S.; Knappe, Svenja; Donley, Elizabeth A.; Kitching, John; Bajaj, Vikram S.; Pines, Alexander

doi:10.1038/srep43994

An optimized microfabricated platform for the optical generation and detection of hyperpolarized ¹²⁹Xe

Journal Article · Tue Mar 07 00:00:00 EST 2017 · Scientific Reports

DOI:https://doi.org/10.1038/srep43994· OSTI ID:1408421

Kennedy, Daniel J. ^[1]; Seltzer, Scott J. ^[1]; Jiménez-Martínez, Ricardo ^[2]; Ring, Hattie L. ^[1]; Malecek, Nicolas S. ^[3]; Knappe, Svenja ^[4]; Donley, Elizabeth A. ^[4]; Kitching, John ^[4]; Bajaj, Vikram S. ^[1]; Pines, Alexander ^[1]

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Science Division; Univ. of California, Berkeley, CA (United States). Dept. of Chemistry
National Inst. of Standards and Technology (NIST), Boulder, CO (United States). Time and Frequency Division; Univ. of Colorado, Boulder, CO (United States). Dept. of Physics
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Science Division
National Inst. of Standards and Technology (NIST), Boulder, CO (United States). Time and Frequency Division

Low thermal-equilibrium nuclear spin polarizations and the need for sophisticated instrumentation render conventional nuclear magnetic resonance (NMR) spectroscopy and imaging (MRI) incompatible with small-scale microfluidic devices. Hyperpolarized ¹²⁹Xe gas has found use in the study of many materials but has required very large and expensive instrumentation. Recently a microfabricated device with modest instrumentation demonstrated all-optical hyperpolarization and detection of ¹²⁹Xe gas. This device was limited by ¹²⁹Xe polarizations less than 1%, ¹²⁹Xe NMR signals smaller than 20 nT, and transport of hyperpolarized ¹²⁹Xe over millimeter lengths. Higher polarizations, versatile detection schemes, and flow of ¹²⁹Xe over larger distances are desirable for wider applications. Here we demonstrate an ultra-sensitive microfabricated platform that achieves ¹²⁹Xe polarizations reaching 7%, NMR signals exceeding 1 μT, lifetimes up to 6 s, and simultaneous two-mode detection, consisting of a high-sensitivity in situ channel with signal-to-noise of 10⁵ and a lower-sensitivity ex situ detection channel which may be useful in a wider variety of conditions. ¹²⁹Xe is hyperpolarized and detected in locations more than 1 cm apart. Our versatile device is an optimal platform for microfluidic magnetic resonance in particular, but equally attractive for wider nuclear spin applications benefitting from ultra-sensitive detection, long coherences, and simple instrumentation.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1408421

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Vol. 7; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Selective excitation of spin-polarized alkali atoms in different ground-state hyperfine levels Ding, Zhichao; Yuan, Jie; Fu, Yangying Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/s41598-017-14431-8	journal	November 2017
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Related Subjects

36 MATERIALS SCIENCE
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
NMR spectroscopy
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