Biodeactivation of Lipopolysaccharide Correlates with Surface‐Bound NO 3 After Cold Atmospheric Plasma Treatment

Bartis, Elliot A. J.; Luan, Pingshan; Knoll, Andrew J.; Graves, David B.; Seog, Joonil; Oehrlein, Gottlieb S.

doi:10.1002/ppap.201500072

Biodeactivation of Lipopolysaccharide Correlates with Surface‐Bound NO ₃ After Cold Atmospheric Plasma Treatment

Journal Article · Mon Nov 23 23:00:00 EST 2015 · Plasma Processes and Polymers

DOI:https://doi.org/10.1002/ppap.201500072· OSTI ID:1400733

Bartis, Elliot A. J. ^[1]; Luan, Pingshan ^[1]; Knoll, Andrew J. ^[1]; Graves, David B. ^[2]; Seog, Joonil ^[1]; Oehrlein, Gottlieb S. ^[1]

Department of Materials Science and Engineering, Institute for Research in Electronics and Applied Physics University of Maryland College Park Maryland 20742 USA
Department of Chemical and Biomolecular Engineering University of California Berkeley California 94720 USA

Cold atmospheric plasma (CAP) treatment of biological surfaces results in important changes of biological functions, but little knowledge on specific surface‐chemical changes is available. We measured surface‐bound NO ₃ on polymer and biomolecular films after CAP treatment. An O ₂ /N ₂ ‐based surface microdischarge was used to deactivate lipopolysaccharide (LPS), an immune‐stimulating biomolecule found in Gram negative bacteria. The observed LPS biodeactivation was highest for low N ₂ concentrations in O ₂ , increased roughly linearly with surface NO ₃ , and then saturated. NO ₃ was also observed after treatment by a very different source: an atmospheric pressure plasma jet operating with an Ar carrier gas. Thus, NO ₃ formation is a generic surface chemical modification of these materials by CAP sources.

View Accepted Manuscript (Publisher)

Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0005105; SC0001939

OSTI ID:: 1400733

Journal Information:: Plasma Processes and Polymers, Journal Name: Plasma Processes and Polymers Journal Issue: 4 Vol. 13; ISSN 1612-8850

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

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Biodeactivation of Lipopolysaccharide Correlates with Surface‐Bound NO 3 After Cold Atmospheric Plasma Treatment

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Biodeactivation of Lipopolysaccharide Correlates with Surface‐Bound NO ₃ After Cold Atmospheric Plasma Treatment