Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core

Tice, Colin M.; Noto, Paul B.; Fan, Kristi Yi; Zhao, Wei; Lotesta, Stephen D.; Dong, Chengguo; Marcus, Andrew P.; Zheng, Ya-Jun; Chen, Guozhou; Wu, Zhongren; Van Orden, Rebecca; Zhou, Jing; Bukhtiyarov, Yuri; Zhao, Yi; Lipinski, Kerri; Howard, Lamont; Guo, Joan; Kandpal, Geeta; Meng, Shi; Hardy, Andrew; Krosky, Paula; Gregg, Richard E.; Leftheris, Katerina; McKeever, Brian M.; Singh, Suresh B.; Lala, Deepak; McGeehan, Gerard M.; Zhuang, Linghang; Claremon, David A.

doi:10.1016/j.bmcl.2016.08.089

Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core

Journal Article · Sat Oct 01 00:00:00 UTC 2016 · Bioorganic and Medicinal Chemistry Letters

DOI:https://doi.org/10.1016/j.bmcl.2016.08.089· OSTI ID:1396353

; Noto, Paul B.; Fan, Kristi Yi; Zhao, Wei; Lotesta, Stephen D.; Dong, Chengguo; Marcus, Andrew P.; ; Chen, Guozhou; Wu, Zhongren; Van Orden, Rebecca; Zhou, Jing; Bukhtiyarov, Yuri; Zhao, Yi; Lipinski, Kerri; Howard, Lamont; Guo, Joan; Kandpal, Geeta; Meng, Shi; Hardy, Andrew more »

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Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-98CH10886

OSTI ID:: 1396353

Journal Information:: Bioorganic and Medicinal Chemistry Letters, Journal Name: Bioorganic and Medicinal Chemistry Letters Journal Issue: 20 Vol. 26; ISSN 0960-894X

Publisher:: ElsevierCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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