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Title: Compositions containing amino acids, phosphate and manganese and their uses

Patent ·
OSTI ID:1390218
;

The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.

Research Organization:
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-04ER63918
Assignee:
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Patent Number(s):
9,758,760
Application Number:
14/962,596
OSTI ID:
1390218
Resource Relation:
Patent File Date: 2015 Dec 08
Country of Publication:
United States
Language:
English

References (24)

Stabilized liquid enzyme composition for glucose determination patent January 1990
Process for the production on an antiviral vaccine, particularly anti-foot and mouth disease vaccine patent September 1990
Infant formulas and nutrition products enriched with nucleosides and/or nucleotides and processes for their preparation patent November 1991
Method and apparatus of a defined serumfree medical solution patent April 1995
Nutritive medium for the culture of microorganism patent July 1996
Method of inactivation of viral and bacterial blood contaminants patent February 2001
Compositions containing amino acids, phosphate and manganese and their uses patent January 2016
Proteins having DNA repair promoting activity patent-application July 2003
Identification of essential genes in microorganisms patent-application February 2004
Capillary membrane stabilization and reduction of tissue injury through use of biodegradable macromolecules with antioxidants and/or other chemicals patent-application November 2006
Sunscreen Safety and Efficacy Enhancement with Manganese Complexes via Urocanate Pathway patent-application August 2007
Vaccines Comprising Multimeric HSP60 Peptide Carriers patent-application October 2009
Protective Vaccine Against Staphylococcus Aureus Biofilms Comprising Cell Wall-Associated Immunogens patent-application July 2011
Compositions Containing Purine Nucleosides and Manganese and Their Uses patent-application July 2011
Vaccination with Irradiated Listeria Induces Protective T Cell Immunity journal July 2006
Death by protein damage in irradiated cells journal January 2012
Accumulation of Mn(II) in Deinococcus radiodurans Facilitates Gamma-Radiation Resistance journal November 2004
Small-Molecule Antioxidant Proteome-Shields in Deinococcus radiodurans journal September 2010
Identification of protein components and quantitative immunoassay for SEC2 in staphylococcin injection journal August 2009
Preserving Immunogenicity of Lethally Irradiated Viral and Bacterial Vaccine Epitopes Using a Radio- Protective Mn2+-Peptide Complex from Deinococcus journal July 2012
Protein damage and death by radiation in Escherichia coli and Deinococcus radiodurans journal July 2010
A Manganese Porphyrin Complex is a Novel Radiation Protector journal July 2004
Potential Utility of Radioprotective Agents in the Practice of Nuclear Medicine journal December 2009
Protein Oxidation Implicated as the Primary Determinant of Bacterial Radioresistance journal March 2007

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