Compositions containing nucleosides and manganese and their uses

Patent · 09 July 2019

OSTI ID:1568561

Daly, Michael J.; Gaidamakova, Elena K.; Matrosova, Vera Y.; Levine, Rodney L.; Wehr, Nancy B.

This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.

• Research Organization: Henry Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (United States); U.S. Dept. of Health and Human Services, Washington, D.C. (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: FG02-04ER63918
• Assignee: The Henry Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, MD); The United States of America as represented by the Department of Health and Human Services (Washington, DC)
• Patent Number(s): 10,342,871
• Application Number: 14/920,765
• OSTI ID: 1568561
• Country of Publication: United States
• Language: English