PET Imaging of Tau Deposition in the Aging Human Brain

Schöll, Michael; Lockhart, Samuel N.; Schonhaut, Daniel R.; O’Neil, James P.; Janabi, Mustafa; Ossenkoppele, Rik; Baker, Suzanne L.; Vogel, Jacob W.; Faria, Jamie; Schwimmer, Henry D.; Rabinovici, Gil D.; Jagust, William J.

doi:10.1016/j.neuron.2016.01.028

PET Imaging of Tau Deposition in the Aging Human Brain

Journal Article · Wed Mar 02 00:00:00 EST 2016 · Neuron

DOI:https://doi.org/10.1016/j.neuron.2016.01.028· OSTI ID:1379129

Schöll, Michael ^[1]; Lockhart, Samuel N. ^[2]; Schonhaut, Daniel R. ^[3]; O’Neil, James P. ^[4]; Janabi, Mustafa ^[4]; Ossenkoppele, Rik ^[5]; Baker, Suzanne L. ^[4]; Vogel, Jacob W. ^[2]; Faria, Jamie ^[4]; Schwimmer, Henry D. ^[2]; Rabinovici, Gil D. ^[6]; Jagust, William J. ^[7]

Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute; University of Gothenburg (Sweden). MedTech West and the Department of Clinical Neuroscience and Rehabilitation
Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute
University of California, San Francisco, CA (United States). Department of Neurology, Memory and Aging Center
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institut; University of California, San Francisco, CA (United States). Department of Neurology, Memory and Aging Center; VU University Medical Center, Amsterdam (The Netherlands). Department of Neurology & Alzheimer Center, Neuroscience Campus Amsterdam
Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute; University of California, San Francisco, CA (United States). Department of Neurology, Memory and Aging Center ; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Tau pathology is a hallmark of Alzheimer’s disease (AD) but also occurs in normal cognitive aging. In this study, using the tau PET agent ¹⁸F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical β-amyloid and was associated with decline in global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. In conclusion, the present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and β-amyloid deposition.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1379129

Journal Information:: Neuron, Journal Name: Neuron Journal Issue: 5 Vol. 89; ISSN 0896-6273

Publisher:: Cell Press / ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Additional file 1 of Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer’s disease pathology: a clinicopathological study Pontecorvo, Michael J.; Keene, C. Dirk; Beach, Thomas G. figshare https://doi.org/10.6084/m9.figshare.12486836	dataset	January 2020
Additional file 1 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes Zhu, Bing; Liu, Yan; Hwang, Spring figshare https://doi.org/10.6084/m9.figshare.20861131	image	January 2022
Additional file 2 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes Zhu, Bing; Liu, Yan; Hwang, Spring figshare https://doi.org/10.6084/m9.figshare.20861134	image	January 2022
Additional file 3 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes Zhu, Bing; Liu, Yan; Hwang, Spring figshare https://doi.org/10.6084/m9.figshare.20861137	image	January 2022
Additional file 4 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes Zhu, Bing; Liu, Yan; Hwang, Spring figshare https://doi.org/10.6084/m9.figshare.20861143.v1	image	January 2022
Additional file 5 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes Zhu, Bing; Liu, Yan; Hwang, Spring figshare https://doi.org/10.6084/m9.figshare.20861146.v1	image	January 2022
Additional file 6 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes Zhu, Bing; Liu, Yan; Hwang, Spring figshare https://doi.org/10.6084/m9.figshare.20861149.v1	image	January 2022
Additional file 7 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes Zhu, Bing; Liu, Yan; Hwang, Spring figshare https://doi.org/10.6084/m9.figshare.20861152.v1	image	January 2022
Additional file 8 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes Zhu, Bing; Liu, Yan; Hwang, Spring figshare https://doi.org/10.6084/m9.figshare.20861158.v1	dataset	January 2022
Additional file 9 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes Zhu, Bing; Liu, Yan; Hwang, Spring figshare https://doi.org/10.6084/m9.figshare.20861164.v1	dataset	January 2022
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Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be? Whitwell, Jennifer L.; Höglinger, Günter U.; Antonini, Angelo Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.15825	text	January 2017
[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia Bevan-Jones, William; Cope, Thomas; Jones, Simon BMJ Publishing Group https://doi.org/10.17863/cam.20229	journalarticle	January 2017
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Amyloid-Negative Dementia in the Elderly is Associated with High Accumulation of Tau in the Temporal Lobes Takeuchi, Jun; Kikukawa, Takayuki; Saito, Haruna The Open Biomedical Engineering Journal, Vol. 13, Issue 1 https://doi.org/10.2174/1874120701913010055	journal	March 2019
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The Relation Between Brain Amyloid Deposition, Cortical Atrophy, and Plasma Biomarkers in Amnesic Mild Cognitive Impairment and Alzheimer’s Disease Fan, Ling-Yun; Tzen, Kai-Yuan; Chen, Ya-Fang Frontiers in Aging Neuroscience, Vol. 10 https://doi.org/10.3389/fnagi.2018.00175	journal	June 2018
Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer’s Disease Barthélemy, Nicolas R.; Mallipeddi, Nipun; Moiseyev, Paul Frontiers in Aging Neuroscience, Vol. 11 https://doi.org/10.3389/fnagi.2019.00121	journal	May 2019
Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease Kametani, Fuyuki; Hasegawa, Masato Frontiers in Neuroscience, Vol. 12 https://doi.org/10.3389/fnins.2018.00025	journal	January 2018
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Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species Chen, Xu-Qiao; Mobley, William C. Frontiers in Neuroscience, Vol. 13 https://doi.org/10.3389/fnins.2019.00659	journal	June 2019
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