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Title: PET Imaging of Tau Deposition in the Aging Human Brain

Abstract

Tau pathology is a hallmark of Alzheimer’s disease (AD) but also occurs in normal cognitive aging. In this study, using the tau PET agent 18F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical β-amyloid and was associated with decline in global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. In conclusion, the present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and β-amyloid deposition.

Authors:
 [1];  [2];  [3];  [4];  [4];  [5];  [4];  [2];  [4];  [2];  [6];  [7]
  1. Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute; University of Gothenburg (Sweden). MedTech West and the Department of Clinical Neuroscience and Rehabilitation
  2. Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute
  3. University of California, San Francisco, CA (United States). Department of Neurology, Memory and Aging Center
  4. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
  5. Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institut; University of California, San Francisco, CA (United States). Department of Neurology, Memory and Aging Center; VU University Medical Center, Amsterdam (The Netherlands). Department of Neurology & Alzheimer Center, Neuroscience Campus Amsterdam
  6. Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute; University of California, San Francisco, CA (United States). Department of Neurology, Memory and Aging Center ; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
  7. Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE; National Institutes of Health (NIH)
OSTI Identifier:
1379129
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Neuron
Additional Journal Information:
Journal Volume: 89; Journal Issue: 5; Journal ID: ISSN 0896-6273
Publisher:
Cell Press / Elsevier
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; tau; amyloid; PET; aging; memory

Citation Formats

Schöll, Michael, Lockhart, Samuel N., Schonhaut, Daniel R., O’Neil, James P., Janabi, Mustafa, Ossenkoppele, Rik, Baker, Suzanne L., Vogel, Jacob W., Faria, Jamie, Schwimmer, Henry D., Rabinovici, Gil D., and Jagust, William J. PET Imaging of Tau Deposition in the Aging Human Brain. United States: N. p., 2016. Web. doi:10.1016/j.neuron.2016.01.028.
Schöll, Michael, Lockhart, Samuel N., Schonhaut, Daniel R., O’Neil, James P., Janabi, Mustafa, Ossenkoppele, Rik, Baker, Suzanne L., Vogel, Jacob W., Faria, Jamie, Schwimmer, Henry D., Rabinovici, Gil D., & Jagust, William J. PET Imaging of Tau Deposition in the Aging Human Brain. United States. doi:10.1016/j.neuron.2016.01.028.
Schöll, Michael, Lockhart, Samuel N., Schonhaut, Daniel R., O’Neil, James P., Janabi, Mustafa, Ossenkoppele, Rik, Baker, Suzanne L., Vogel, Jacob W., Faria, Jamie, Schwimmer, Henry D., Rabinovici, Gil D., and Jagust, William J. Wed . "PET Imaging of Tau Deposition in the Aging Human Brain". United States. doi:10.1016/j.neuron.2016.01.028. https://www.osti.gov/servlets/purl/1379129.
@article{osti_1379129,
title = {PET Imaging of Tau Deposition in the Aging Human Brain},
author = {Schöll, Michael and Lockhart, Samuel N. and Schonhaut, Daniel R. and O’Neil, James P. and Janabi, Mustafa and Ossenkoppele, Rik and Baker, Suzanne L. and Vogel, Jacob W. and Faria, Jamie and Schwimmer, Henry D. and Rabinovici, Gil D. and Jagust, William J.},
abstractNote = {Tau pathology is a hallmark of Alzheimer’s disease (AD) but also occurs in normal cognitive aging. In this study, using the tau PET agent 18F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical β-amyloid and was associated with decline in global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. In conclusion, the present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and β-amyloid deposition.},
doi = {10.1016/j.neuron.2016.01.028},
journal = {Neuron},
issn = {0896-6273},
number = 5,
volume = 89,
place = {United States},
year = {2016},
month = {3}
}

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Extracellular Vesicle Biology in Alzheimer’s Disease and Related Tauopathy
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Brain Theranostics and Radiotheranostics: Exosomes and Graphenes In Vivo as Novel Brain Theranostics
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Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [ 11 C]PBB3‐PET study
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Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy
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Imaging the evolution and pathophysiology of Alzheimer disease
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journal, April 2018

  • Adams, Jenna N.; Lockhart, Samuel N.; Li, Lexin
  • Cerebral Cortex, Vol. 29, Issue 5
  • DOI: 10.1093/cercor/bhy078

The Influence of Dopamine on Cognitive Flexibility Is Mediated by Functional Connectivity in Young but Not Older Adults
journal, September 2018

  • Berry, Anne S.; Shah, Vyoma D.; Jagust, William J.
  • Journal of Cognitive Neuroscience, Vol. 30, Issue 9
  • DOI: 10.1162/jocn_a_01286

Secondary prevention of Alzheimer’s dementia: neuroimaging contributions
journal, October 2018

  • ten Kate, Mara; Ingala, Silvia; Schwarz, Adam J.
  • Alzheimer's Research & Therapy, Vol. 10, Issue 1
  • DOI: 10.1186/s13195-018-0438-z

Associations between quantitative [18F]flortaucipir tau PET and atrophy across the Alzheimer’s disease spectrum
journal, July 2019

  • Timmers, Tessa; Ossenkoppele, Rik; Wolters, Emma E.
  • Alzheimer's Research & Therapy, Vol. 11, Issue 1
  • DOI: 10.1186/s13195-019-0510-3

A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus
journal, August 2018


Amyloid-Negative Dementia in the Elderly is Associated with High Accumulation of Tau in the Temporal Lobes
journal, March 2019

  • Takeuchi, Jun; Kikukawa, Takayuki; Saito, Haruna
  • The Open Biomedical Engineering Journal, Vol. 13, Issue 1
  • DOI: 10.2174/1874120701913010055

Plasma Neurofilament Light and Alzheimer’s Disease Biomarkers in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI)
journal, July 2019

  • Rafii, Michael S.; Donohue, Michael C.; Matthews, Dawn C.
  • Journal of Alzheimer's Disease, Vol. 70, Issue 1
  • DOI: 10.3233/jad-190322

Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species
journal, June 2019


MRI-Driven PET Image Optimization for Neurological Applications
journal, July 2019


Simultaneous Covariance Inference for Multimodal Integrative Analysis
text, January 2019


Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline: Tau, Amyloid, FDG, and Memory in Normal Aging
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