Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications

Wu, Xiang; Zhang, Yuanwei; Takle, Kendra; Bilsel, Osman; Li, Zhanjun; Lee, Hyungseok; Zhang, Zijiao; Li, Dongsheng; Fan, Wei; Duan, Chunying; Chan, Emory M.; Lois, Carlos; Xiang, Yang; Han, Gang

doi:10.1021/acsnano.5b06383

Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications

Journal Article · Tue Jan 05 23:00:00 EST 2016 · ACS Nano

DOI:https://doi.org/10.1021/acsnano.5b06383· OSTI ID:1379046

Wu, Xiang ^[1]; Zhang, Yuanwei ^[2]; Takle, Kendra ^[3]; Bilsel, Osman ^[2]; Li, Zhanjun ^[2]; Lee, Hyungseok ^[2]; Zhang, Zijiao ^[4]; Li, Dongsheng ^[5]; Fan, Wei ^[6]; Duan, Chunying ^[7]; Chan, Emory M. ^[8]; Lois, Carlos ^[3]; Xiang, Yang ^[3]; Han, Gang ^[2]

Univ. of Massachusetts Medical School, Worcester, MA (United States). Dept. of Biochemistry and Molecular Pharmacology; Dalian Univ. of Technology (People's Republic of China)
Univ. of Massachusetts Medical School, Worcester, MA (United States). Dept. of Biochemistry and Molecular Pharmacology
Univ. of Massachusetts Medical School, Worcester, MA (United States). Neurobiology Dept.
Zhejiang Univ., Hangzhou (China).. Dept. of Materials Science and Engineering
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Univ. of Massachusetts, Amherst, MA (United States). Chemical Engineering Dept.
Dalian Univ. of Technology (People's Republic of China). State Key Lab. of Fine Chemicals
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). The Molecular Foundry

A near-infrared (NIR) dye-sensitized upconversion nanoparticles (UCNPs) can broaden the absorption range and boost upconversion efficiency of UCNPs. We achieved significantly enhanced upconversion luminescence in dye-sensitized core/active shell UCNPs via the doping of ytterbium ions (Yb ³⁺ ) in the UCNP shell, which bridged the energy transfer from the dye to the UCNP core. As a result, we synergized the two most practical upconversion booster effectors (dye-sensitizing and core/shell enhancement) to amplify upconversion efficiency. We also demonstrated two biomedical applications using these UCNPs. By using dye-sensitized core/active shell UCNP embedded poly(methyl methacrylate) polymer implantable systems, we successfully shifted the optogenetic neuron excitation window to a biocompatible and deep tissue penetrable 800 nm wavelength. Furthermore, UCNPs were water-solubilized with Pluronic F127 with high upconversion efficiency and can be imaged in a mouse model.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); National Institutes of Health (NIH)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1379046

Alternate ID(s):: OSTI ID: 1337277

Journal Information:: ACS Nano, Journal Name: ACS Nano Journal Issue: 1 Vol. 10; ISSN 1936-0851

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

References (43)

The Active-Core/Active-Shell Approach: A Strategy to Enhance the Upconversion Luminescence in Lanthanide-Doped Nanoparticles Vetrone, Fiorenzo; Naccache, Rafik; Mahalingam, Venkataramanan Advanced Functional Materials, Vol. 19, Issue 18 https://doi.org/10.1002/adfm.200900234	journal	September 2009
Poly(Acrylic Acid) Modification of Nd ³⁺ -Sensitized Upconversion Nanophosphors for Highly Efficient UCL Imaging and pH-Responsive Drug Delivery Liu, Bei; Chen, Yinyin; Li, Chunxia Advanced Functional Materials, Vol. 25, Issue 29 https://doi.org/10.1002/adfm.201501582	journal	June 2015
Rare-Earth Ion Doped Up-Conversion Materials for Photovoltaic Applications Wang, Hai-Qiao; Batentschuk, Miroslaw; Osvet, Andres Advanced Materials, Vol. 23, Issue 22-23 https://doi.org/10.1002/adma.201100511	journal	April 2011
Rationally Designed Energy Transfer in Upconverting Nanoparticles Chan, Emory M.; Levy, Elizabeth S.; Cohen, Bruce E. Advanced Materials, Vol. 27, Issue 38 https://doi.org/10.1002/adma.201500248	journal	March 2015
Engineering the Upconversion Nanoparticle Excitation Wavelength: Cascade Sensitization of Tri-doped Upconversion Colloidal Nanoparticles at 800 nm Shen, Jie; Chen, Guanying; Vu, Anne-Marie Advanced Optical Materials, Vol. 1, Issue 9 https://doi.org/10.1002/adom.201300160	journal	July 2013
Direct Evidence of a Surface Quenching Effect on Size-Dependent Luminescence of Upconversion Nanoparticles Wang, Feng; Wang, Juan; Liu, Xiaogang Angewandte Chemie International Edition, Vol. 49, Issue 41 https://doi.org/10.1002/anie.201003959	journal	August 2010
Upconverting Nanoparticles Haase, Markus; Schäfer, Helmut Angewandte Chemie International Edition, Vol. 50, Issue 26 https://doi.org/10.1002/anie.201005159	journal	May 2011
In Vitro and In Vivo Uncaging and Bioluminescence Imaging by Using Photocaged Upconversion Nanoparticles Yang, Yanmei; Shao, Qing; Deng, Renren Angewandte Chemie International Edition, Vol. 51, Issue 13 https://doi.org/10.1002/anie.201107919	journal	January 2012
Enhancing Luminescence in Lanthanide-Doped Upconversion Nanoparticles Han, Sanyang; Deng, Renren; Xie, Xiaoji Angewandte Chemie International Edition, Vol. 53, Issue 44 https://doi.org/10.1002/anie.201403408	journal	September 2014
Quantitative analysis of transcranial and intraparenchymal light penetration in human cadaver brain tissue: TRANSCRANIAL AND INTRAPARENCHYMAL LIGHT PENETRATION Tedford, Clark E.; DeLapp, Scott; Jacques, Steven Lasers in Surgery and Medicine, Vol. 47, Issue 4 https://doi.org/10.1002/lsm.22343	journal	March 2015
Upconversion: Tunable Near Infrared to Ultraviolet Upconversion Luminescence Enhancement in (α-NaYF ₄ :Yb,Tm)/CaF ₂ Core/Shell Nanoparticles for In situ Real-time Recorded Biocompatible Photoactivation (Small 19/2013) Shen, Jie; Chen, Guanying; Ohulchanskyy, Tymish Y. Small, Vol. 9, Issue 19 https://doi.org/10.1002/smll.201370117	journal	October 2013
Lanthanide-doped upconverting luminescent nanoparticle platforms for optical imaging-guided drug delivery and therapy Shen, Jie; Zhao, Liang; Han, Gang Advanced Drug Delivery Reviews, Vol. 65, Issue 5 https://doi.org/10.1016/j.addr.2012.05.007	journal	May 2013
Protein modified upconversion nanoparticles for imaging-guided combined photothermal and photodynamic therapy Chen, Qian; Wang, Chao; Cheng, Liang Biomaterials, Vol. 35, Issue 9 https://doi.org/10.1016/j.biomaterials.2013.12.046	journal	March 2014
Antigen-Loaded Upconversion Nanoparticles for Dendritic Cell Stimulation, Tracking, and Vaccination in Dendritic Cell-Based Immunotherapy Xiang, Jian; Xu, Ligeng; Gong, Hua ACS Nano, Vol. 9, Issue 6 https://doi.org/10.1021/acsnano.5b02014	journal	May 2015
Upconversion Nanoparticles: A Versatile Solution to Multiscale Biological Imaging Wu, Xiang; Chen, Guanying; Shen, Jie Bioconjugate Chemistry, Vol. 26, Issue 2 https://doi.org/10.1021/bc5003967	journal	October 2014
High-Quality Sodium Rare-Earth Fluoride Nanocrystals: Controlled Synthesis and Optical Properties Mai, Hao-Xin; Zhang, Ya-Wen; Si, Rui Journal of the American Chemical Society, Vol. 128, Issue 19 https://doi.org/10.1021/ja060212h	journal	May 2006
Sub-10 nm Hexagonal Lanthanide-Doped NaLuF ₄ Upconversion Nanocrystals for Sensitive Bioimaging in Vivo Liu, Qian; Sun, Yun; Yang, Tianshe Journal of the American Chemical Society, Vol. 133, Issue 43 https://doi.org/10.1021/ja207078s	journal	November 2011
Encapsulation of Hydrophobic Drugs in Pluronic F127 Micelles: Effects of Drug Hydrophobicity, Solution Temperature, and pH Basak, Rajib; Bandyopadhyay, Ranjini Langmuir, Vol. 29, Issue 13 https://doi.org/10.1021/la304836e	journal	February 2013
(α-NaYbF ₄ :Tm ³⁺ )/CaF ₂ Core/Shell Nanoparticles with Efficient Near-Infrared to Near-Infrared Upconversion for High-Contrast Deep Tissue Bioimaging Chen, Guanying; Shen, Jie; Ohulchanskyy, Tymish Y. ACS Nano, Vol. 6, Issue 9 https://doi.org/10.1021/nn302972r	journal	August 2012
Nd ³⁺ -Sensitized Upconversion Nanophosphors: Efficient In Vivo Bioimaging Probes with Minimized Heating Effect Wang, Ye-Fu; Liu, Gao-Yuan; Sun, Ling-Dong ACS Nano, Vol. 7, Issue 8 https://doi.org/10.1021/nn402601d	journal	July 2013
Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy Punjabi, Amol; Wu, Xiang; Tokatli-Apollon, Amira ACS Nano, Vol. 8, Issue 10 https://doi.org/10.1021/nn505051d	journal	October 2014
Multimodal fast optical interrogation of neural circuitry Zhang, Feng; Wang, Li-Ping; Brauner, Martin Nature, Vol. 446, Issue 7136 https://doi.org/10.1038/nature05744	journal	April 2007
Upconversion goes broadband Xie, Xiaoji; Liu, Xiaogang Nature Materials, Vol. 11, Issue 10 https://doi.org/10.1038/nmat3426	journal	September 2012
Scanless two-photon excitation of channelrhodopsin-2 Papagiakoumou, Eirini; Anselmi, Francesca; Bègue, Aurélien Nature Methods, Vol. 7, Issue 10 https://doi.org/10.1038/nmeth.1505	journal	September 2010
ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation Lin, John Y.; Knutsen, Per Magne; Muller, Arnaud Nature Neuroscience, Vol. 16, Issue 10 https://doi.org/10.1038/nn.3502	journal	September 2013
Millisecond-timescale, genetically targeted optical control of neural activity Boyden, Edward S.; Zhang, Feng; Bamberg, Ernst Nature Neuroscience, Vol. 8, Issue 9 https://doi.org/10.1038/nn1525	journal	August 2005
Remote control of ion channels and neurons through magnetic-field heating of nanoparticles Huang, Heng; Delikanli, Savas; Zeng, Hao Nature Nanotechnology, Vol. 5, Issue 8 https://doi.org/10.1038/nnano.2010.125	journal	June 2010
Broadband dye-sensitized upconversion of near-infrared light Zou, Wenqiang; Visser, Cindy; Maduro, Jeremio A. Nature Photonics, Vol. 6, Issue 8 https://doi.org/10.1038/nphoton.2012.158	journal	July 2012
Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics McCall, Jordan G.; Kim, Tae-il; Shin, Gunchul Nature Protocols, Vol. 8, Issue 12, p. 2413-2428 https://doi.org/10.1038/nprot.2013.158	journal	November 2013
Upconversion nanophosphors for small-animal imaging Zhou, Jing; Liu, Zhuang; Li, Fuyou Chem. Soc. Rev., Vol. 41, Issue 3 https://doi.org/10.1039/C1CS15187H	journal	January 2012
Photon upconversion in core–shell nanoparticles Chen, Xian; Peng, Denfeng; Ju, Qiang Chemical Society Reviews, Vol. 44, Issue 6 https://doi.org/10.1039/C4CS00151F	journal	January 2015
Current advances in lanthanide ion (Ln ³⁺ )-based upconversion nanomaterials for drug delivery Yang, Dongmei; Ma, Ping'an; Hou, Zhiyou Chemical Society Reviews, Vol. 44, Issue 6 https://doi.org/10.1039/C4CS00155A	journal	January 2015
Upconversion nanoparticles as versatile light nanotransducers for photoactivation applications Idris, Niagara Muhammad; Jayakumar, Muthu Kumara Gnanasammandhan; Bansal, Akshaya Chemical Society Reviews, Vol. 44, Issue 6 https://doi.org/10.1039/C4CS00158C	journal	January 2015
Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals Wang, Feng; Liu, Xiaogang Chemical Society Reviews, Vol. 38, Issue 4 https://doi.org/10.1039/b809132n	journal	January 2009
Colloidal synthesis and remarkable enhancement of the upconversion luminescence of BaGdF5:Yb3+/Er3+ nanoparticles by active-shell modification Yang, Dongmei; Li, Chunxia; Li, Guogang Journal of Materials Chemistry, Vol. 21, Issue 16 https://doi.org/10.1039/c0jm04179c	journal	January 2011
Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction Shi Kam, N. W.; O'Connell, M.; Wisdom, J. A. Proceedings of the National Academy of Sciences, Vol. 102, Issue 33, p. 11600-11605 https://doi.org/10.1073/pnas.0502680102	journal	August 2005
Remote activation of biomolecules in deep tissues using near-infrared-to-UV upconversion nanotransducers Jayakumar, M. K. G.; Idris, N. M.; Zhang, Y. Proceedings of the National Academy of Sciences, Vol. 109, Issue 22 https://doi.org/10.1073/pnas.1114551109	journal	May 2012
Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics Kim, T.-i.; McCall, J. G.; Jung, Y. H. Science, Vol. 340, Issue 6129, p. 211-216 https://doi.org/10.1126/science.1232437	journal	April 2013
Implanted Neural Interfaces: Biochallenges and Engineered Solutions Grill, Warren M.; Norman, Sharon E.; Bellamkonda, Ravi V. Annual Review of Biomedical Engineering, Vol. 11, Issue 1 https://doi.org/10.1146/annurev-bioeng-061008-124927	journal	August 2009
The Development and Application of Optogenetics Fenno, Lief; Yizhar, Ofer; Deisseroth, Karl Annual Review of Neuroscience, Vol. 34, Issue 1 https://doi.org/10.1146/annurev-neuro-061010-113817	journal	July 2011
In-Depth Activation of Channelrhodopsin 2-Sensitized Excitable Cells with High Spatial Resolution Using Two-Photon Excitation with a Near-Infrared Laser Microbeam Mohanty, Samarendra K.; Reinscheid, Rainer K.; Liu, Xiaobin Biophysical Journal, Vol. 95, Issue 8 https://doi.org/10.1529/biophysj.108.130187	journal	October 2008
Bioconjugated Pluronic Triblock-Copolymer Micelle-Encapsulated Quantum Dots for Targeted Imaging of Cancer: In Vitro and In Vivo Studies Liu, Liwei; Yong, Ken-Tye; Roy, Indrajit Theranostics, Vol. 2, Issue 7 https://doi.org/10.7150/thno.3456	journal	January 2012
Theranostic Upconversion Nanoparticles (I) Chen, Guanying; Han, Gang Theranostics, Vol. 3, Issue 4 https://doi.org/10.7150/thno.6382	journal	January 2013

Cited By (97)

Lanthanide-Doped Upconversion Nanoparticles: Emerging Intelligent Light-Activated Drug Delivery Systems Bagheri, Ali; Arandiyan, Hamidreza; Boyer, Cyrille Advanced Science, Vol. 3, Issue 7 https://doi.org/10.1002/advs.201500437	journal	March 2016
A Universal Strategy to Construct Lanthanide-Doped Nanoparticles-Based Activable NIR-II Luminescence Probe for Bioimaging Li, Zhen; Wu, Junjie; Wang, Qirong iScience, Vol. 23, Issue 3 https://doi.org/10.1016/j.isci.2020.100962	journal	March 2020
Dye-Sensitized Downconversion Wang, Zijun; Meijerink, Andries The Journal of Physical Chemistry Letters, Vol. 9, Issue 7 https://doi.org/10.1021/acs.jpclett.8b00516	journal	March 2018
Recent Development of Inorganic Nanoparticles for Biomedical Imaging Kim, Dokyoon; Kim, Jonghoon; Park, Yong Il ACS Central Science, Vol. 4, Issue 3 https://doi.org/10.1021/acscentsci.7b00574	journal	January 2018
Intracellular localization of nanoparticle dimers by chirality reversal Sun, Maozhong; Xu, Liguang; Bahng, Joong Hwan Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/s41467-017-01337-2	journal	November 2017
Upconversion nanocomposite for programming combination cancer therapy by precise control of microscopic temperature Zhu, Xingjun; Li, Jiachang; Qiu, Xiaochen Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-04571-4	journal	June 2018
Advances in highly doped upconversion nanoparticles Wen, Shihui; Zhou, Jiajia; Zheng, Kezhi Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-04813-5	journal	June 2018
Upconversion amplification through dielectric superlensing modulation Liang, Liangliang; Teh, Daniel B. L.; Dinh, Ngoc-Duy Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-09345-0	journal	March 2019
Upconversion superballs for programmable photoactivation of therapeutics Zhang, Zhen; Jayakumar, Muthu Kumara Gnanasammandhan; Zheng, Xiang Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-12506-w	journal	October 2019
Co-delivery of brinzolamide and miRNA-124 by biodegradable nanoparticles as a strategy for glaucoma therapy Li, Tingting; Wang, Ye; Chen, Jiahao Drug Delivery, Vol. 27, Issue 1 https://doi.org/10.1080/10717544.2020.1731861	journal	January 2020
The nanomaterial toolkit for neuroengineering Shah, Shreyas Nano Convergence, Vol. 3, Issue 1 https://doi.org/10.1186/s40580-016-0086-6	journal	October 2016
Construction of Multicolor Upconversion Nanotheranostic Agent for in-situ Cooperative Photodynamic Therapy for Deep-Seated Malignant Tumors Hong, Tongtong; Jiang, Yanxialei; Yue, Zihong Frontiers in Chemistry, Vol. 8 https://doi.org/10.3389/fchem.2020.00052	journal	February 2020
Recent Progress in Upconversion Photodynamic Therapy Qiu, Hailong; Tan, Meiling; Ohulchanskyy, Tymish Nanomaterials, Vol. 8, Issue 5 https://doi.org/10.3390/nano8050344	journal	May 2018
Simultaneous Dual-mode Emission and Tunable Multicolor in the Time Domain from Lanthanide-doped Core-shell Microcrystals Ju, Dandan; Song, Feng; Khan, Adnan Nanomaterials, Vol. 8, Issue 12 https://doi.org/10.3390/nano8121023	journal	December 2018
Near‐Infrared Manipulation of Membrane Ion Channels via Upconversion Optogenetics Wang, Zhimin; Hu, Ming; Ai, Xiangzhao Advanced Biosystems, Vol. 3, Issue 1 https://doi.org/10.1002/adbi.201800233	journal	November 2018
Luminescent Ions in Advanced Composite Materials for Multifunctional Applications Bai, Gongxun; Tsang, Ming-Kiu; Hao, Jianhua Advanced Functional Materials, Vol. 26, Issue 35 https://doi.org/10.1002/adfm.201602142	journal	July 2016
Er ³⁺ Sensitized Photon Upconversion Nanocrystals Cheng, Xingwen; Pan, Yue; Yuan, Ze Advanced Functional Materials, Vol. 28, Issue 22 https://doi.org/10.1002/adfm.201800208	journal	April 2018
Band Gap Engineering Improves the Efficiency of Double Quantum Dot Upconversion Nanocrystals Yang, Gaoling; Meir, Noga; Raanan, Dekel Advanced Functional Materials, Vol. 29, Issue 23 https://doi.org/10.1002/adfm.201900755	journal	April 2019
Near‐Infrared‐Light Activatable Nanoparticles for Deep‐Tissue‐Penetrating Wireless Optogenetics Yu, Nuo; Huang, Ling; Zhou, Yubin Advanced Healthcare Materials, Vol. 8, Issue 6 https://doi.org/10.1002/adhm.201801132	journal	January 2019
Ultra-Wideband Multi-Dye-Sensitized Upconverting Nanoparticles for Information Security Application Lee, Jongha; Yoo, Byeongjun; Lee, Hakyong Advanced Materials, Vol. 29, Issue 1 https://doi.org/10.1002/adma.201603169	journal	October 2016
808-nm-Light-Excited Lanthanide-Doped Nanoparticles: Rational Design, Luminescence Control and Theranostic Applications Liu, Bei; Li, Chunxia; Yang, Piaoping Advanced Materials, Vol. 29, Issue 18 https://doi.org/10.1002/adma.201605434	journal	March 2017
Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery Han, Sanyang; Samanta, Animesh; Xie, Xiaoji Advanced Materials, Vol. 29, Issue 18 https://doi.org/10.1002/adma.201700244	journal	March 2017
Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery Han, Sanyang; Samanta, Animesh; Xie, Xiaoji Advanced Materials, Vol. 29, Issue 40 https://doi.org/10.1002/adma.201704811	journal	October 2017
Photothermal-Responsive Conjugated Polymer Nanoparticles for Remote Control of Gene Expression in Living Cells Wang, Yunxia; Li, Shengliang; Zhang, Pengbo Advanced Materials, Vol. 30, Issue 8 https://doi.org/10.1002/adma.201705418	journal	January 2018
Expanding the Toolbox of Upconversion Nanoparticles for In Vivo Optogenetics and Neuromodulation All, Angelo Homayoun; Zeng, Xiao; Teh, Daniel Boon Loong Advanced Materials, Vol. 31, Issue 41 https://doi.org/10.1002/adma.201803474	journal	August 2019
NIR Biosensing of Neurotransmitters in Stem Cell‐Derived Neural Interface Using Advanced Core–Shell Upconversion Nanoparticles Rabie, Hudifah; Zhang, Yixiao; Pasquale, Nicholas Advanced Materials, Vol. 31, Issue 14 https://doi.org/10.1002/adma.201806991	journal	February 2019
Nanotransducers for Near‐Infrared Photoregulation in Biomedicine Li, Jingchao; Duan, Hongwei; Pu, Kanyi Advanced Materials, Vol. 31, Issue 33 https://doi.org/10.1002/adma.201901607	journal	June 2019
Up-Conversion Fluorescent Labels for Plastic Recycling: A Review Gao, Guojun; Turshatov, Andrey; Howard, Ian A. Advanced Sustainable Systems, Vol. 1, Issue 5 https://doi.org/10.1002/adsu.201600033	journal	May 2017
Advanced Near-Infrared Light-Responsive Nanomaterials as Therapeutic Platforms for Cancer Therapy Chien, Yi-Hsin; Chan, Kok Ken; Anderson, Tommy Advanced Therapeutics, Vol. 2, Issue 3 https://doi.org/10.1002/adtp.201800090	journal	November 2018
A Strategy of NIR Dual‐Excitation Upconversion for Ratiometric Intracellular Detection Ke, Jianxi; Lu, Shan; Shang, Xiaoying Advanced Science, Vol. 6, Issue 22 https://doi.org/10.1002/advs.201901874	journal	September 2019
Intrinsic Time‐Tunable Emissions in Core–Shell Upconverting Nanoparticle Systems Tessitore, Gabriella; Maurizio, Steven L.; Sabri, Tarek Angewandte Chemie, Vol. 131, Issue 29 https://doi.org/10.1002/ange.201904445	journal	June 2019
Boosting Luminance Energy Transfer Efficiency in Upconversion Nanoparticles with an Energy‐Concentrating Zone Zhang, Xiaobo; Chen, Weiwei; Xie, Xiaoyu Angewandte Chemie, Vol. 131, Issue 35 https://doi.org/10.1002/ange.201906380	journal	July 2019
Intrinsic Time‐Tunable Emissions in Core–Shell Upconverting Nanoparticle Systems Tessitore, Gabriella; Maurizio, Steven L.; Sabri, Tarek Angewandte Chemie International Edition, Vol. 58, Issue 29 https://doi.org/10.1002/anie.201904445	journal	July 2019
Boosting Luminance Energy Transfer Efficiency in Upconversion Nanoparticles with an Energy‐Concentrating Zone Zhang, Xiaobo; Chen, Weiwei; Xie, Xiaoyu Angewandte Chemie International Edition, Vol. 58, Issue 35 https://doi.org/10.1002/anie.201906380	journal	August 2019
Upconversion in Nanostructured Materials: From Optical Tuning to Biomedical Applications Sun, Tianying; Ai, Fujin; Zhu, Guangyu Chemistry - An Asian Journal, Vol. 13, Issue 4 https://doi.org/10.1002/asia.201701660	journal	January 2018
Energy Transfer in Dye-Coupled Lanthanide-Doped Nanoparticles: From Design to Application Wang, Juan; Deng, Renren Chemistry - An Asian Journal, Vol. 13, Issue 6 https://doi.org/10.1002/asia.201701817	journal	February 2018
Towards Efficient and Photostable Red‐Emitting Photonic Materials Based on Symmetric All‐BODIPY‐Triads, ‐Pentads, and ‐Hexads Avellanal‐Zaballa, Edurne; Ventura, Juan; Gartzia‐Rivero, Leire Chemistry – A European Journal, Vol. 25, Issue 65 https://doi.org/10.1002/chem.201903804	journal	October 2019
Photophysics of Up‐Conversion Nanoparticles: Radical Photopolymerization of Multifunctional Methacrylates Comprising Blue‐ and UV‐Sensitive Photoinitiators Oprych, Dennis; Schmitz, Christian; Ley, Christian ChemPhotoChem, Vol. 3, Issue 11 https://doi.org/10.1002/cptc.201900196	journal	August 2019
Core or Shell? Er ³⁺ FRET Donors in Upconversion Nanoparticles: Core or Shell? Er ³⁺ FRET Donors in Upconversion Nanoparticles Bhuckory, Shashi; Hemmer, Eva; Wu, Yu-Tang European Journal of Inorganic Chemistry, Vol. 2017, Issue 44 https://doi.org/10.1002/ejic.201700904	journal	October 2017
Photon Upconversion Kinetic Nanosystems and Their Optical Response: Photon Upconversion Kinetic Nanosystems and Their Optical Response Liu, Haichun; Huang, Kai; Valiev, Rashid R. Laser & Photonics Reviews, Vol. 12, Issue 1 https://doi.org/10.1002/lpor.201700144	journal	November 2017
Organic Soluble LaPO ₄ :Eu ³⁺ Nanorods: Sensitization of Surface Eu ³⁺ Ions and Phase Transfer in Water Vats, Bal Govind; Shafeeq, Muhammed; Singhal, Pallavi ChemistrySelect, Vol. 3, Issue 17 https://doi.org/10.1002/slct.201800276	journal	May 2018
Energy Migration Upconversion in Ce(III)-Doped Heterogeneous Core−Shell−Shell Nanoparticles Chen, Xian; Jin, Limin; Sun, Tianying Small, Vol. 13, Issue 43 https://doi.org/10.1002/smll.201701479	journal	July 2017
Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics Noh, Kyung Nim; Park, Sung Il; Qazi, Raza Small, Vol. 14, Issue 4 https://doi.org/10.1002/smll.201702479	journal	December 2017
Lanthanide Doped Near Infrared Active Upconversion Nanophosphors: Fundamental Concepts, Synthesis Strategies, and Technological Applications Lingeshwar Reddy, Kumbam; Balaji, Ramachandran; Kumar, Ashish Small, Vol. 14, Issue 37 https://doi.org/10.1002/smll.201801304	journal	July 2018
Neodymium‐Sensitized Nanoconstructs for Near‐Infrared Enabled Photomedicine Yu, Zhongzheng; Chan, Wen Kiat; Tan, Timothy Thatt Yang Small, Vol. 16, Issue 1 https://doi.org/10.1002/smll.201905265	journal	November 2019
Upconversion Nanoparticles–Based Multiplex Protein Activation to Neuron Ablation for Locomotion Regulation Zhang, Yan; Zhang, Wanmei; Zeng, Kanghua Small, Vol. 16, Issue 8 https://doi.org/10.1002/smll.201906797	journal	January 2020
Perspectives and challenges of photon-upconversion nanoparticles - Part I: routes to brighter particles and quantitative spectroscopic studies Resch-Genger, Ute; Gorris, Hans H. Analytical and Bioanalytical Chemistry, Vol. 409, Issue 25 https://doi.org/10.1007/s00216-017-0499-z	journal	July 2017
Brain Photobiomodulation Therapy: a Narrative Review Salehpour, Farzad; Mahmoudi, Javad; Kamari, Farzin Molecular Neurobiology, Vol. 55, Issue 8 https://doi.org/10.1007/s12035-017-0852-4	journal	January 2018
Near-infrared light activated persistent luminescence nanoparticles via upconversion Li, Zhanjun; Huang, Ling; Zhang, Yuanwei Nano Research, Vol. 10, Issue 5 https://doi.org/10.1007/s12274-017-1548-9	journal	March 2017
Luminescent Rare-earth-based Nanoparticles: A Summarized Overview of their Synthesis, Functionalization, and Applications Escudero, Alberto; Carrillo-Carrión, Carolina; Zyuzin, Mikhail V. Topics in Current Chemistry, Vol. 374, Issue 4 https://doi.org/10.1007/s41061-016-0049-8	journal	July 2016
Utilizing the power of Cerenkov light with nanotechnology Shaffer, Travis M.; Pratt, Edwin C.; Grimm, Jan Nature Nanotechnology, Vol. 12, Issue 2 https://doi.org/10.1038/nnano.2016.301	journal	February 2017
Near-infrared light-mediated rare-earth nanocrystals: recent advances in improving photon conversion and alleviating the thermal effect Lyu, Linna; Cheong, Haolun; Ai, Xiangzhao NPG Asia Materials, Vol. 10, Issue 8 https://doi.org/10.1038/s41427-018-0065-y	journal	August 2018
Achieving high-efficiency emission depletion nanoscopy by employing cross relaxation in upconversion nanoparticles Zhan, Qiuqiang; Liu, Haichun; Wang, Baoju Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/s41467-017-01141-y	journal	October 2017
Continuous-wave upconverting nanoparticle microlasers Fernandez-Bravo, Angel; Yao, Kaiyuan; Barnard, Edward S. Nature Nanotechnology, Vol. 13, Issue 7 https://doi.org/10.1038/s41565-018-0161-8	journal	June 2018
Activation of the surface dark-layer to enhance upconversion in a thermal field Zhou, Jiajia; Wen, Shihui; Liao, Jiayan Nature Photonics, Vol. 12, Issue 3 https://doi.org/10.1038/s41566-018-0108-5	journal	February 2018
Enrichment of molecular antenna triplets amplifies upconverting nanoparticle emission Garfield, David J.; Borys, Nicholas J.; Hamed, Samia M. Nature Photonics, Vol. 12, Issue 7 https://doi.org/10.1038/s41566-018-0156-x	journal	April 2018
Future and challenges for hybrid upconversion nanosystems Wen, Shihui; Zhou, Jiajia; Schuck, P. James Nature Photonics, Vol. 13, Issue 12 https://doi.org/10.1038/s41566-019-0528-x	journal	October 2019
A water-dispersible dye-sensitized upconversion nanocomposite modified with phosphatidylcholine for lymphatic imaging Zou, Xianmei; Xu, Ming; Yuan, Wei Chemical Communications, Vol. 52, Issue 91 https://doi.org/10.1039/c6cc07180e	journal	January 2016
Anti-Stokes shift luminescent materials for bio-applications Zhu, Xingjun; Su, Qianqian; Feng, Wei Chemical Society Reviews, Vol. 46, Issue 4 https://doi.org/10.1039/c6cs00415f	journal	January 2017
Revisiting the optimized doping ratio in core/shell nanostructured upconversion particles Shen, Bin; Cheng, Shengming; Gu, Yuyang Nanoscale, Vol. 9, Issue 5 https://doi.org/10.1039/c6nr07687d	journal	January 2017
Dye-sensitized lanthanide-doped upconversion nanoparticles Wang, Xindong; Valiev, Rashid R.; Ohulchanskyy, Tymish Y. Chemical Society Reviews, Vol. 46, Issue 14 https://doi.org/10.1039/c7cs00053g	journal	January 2017
Huge enhancement of upconversion luminescence by dye/Nd ³⁺ sensitization of quenching-shield sandwich structured upconversion nanocrystals under 808 nm excitation Zhao, Feifei; Yin, Dongguang; Wu, Chenglong Dalton Transactions, Vol. 46, Issue 46 https://doi.org/10.1039/c7dt03383d	journal	January 2017
NIR/blue light emission optimization of NaY _1−(x+y) Yb _x F ₄ :Tm _y upconversion nanoparticles via Yb ³⁺ /Tm ³⁺ dopant balancing Bagheri, Ali; Li, Zheye; Boyer, Cyrille Dalton Transactions, Vol. 47, Issue 26 https://doi.org/10.1039/c7dt04768a	journal	January 2018
In situ crystal growth of gold nanocrystals on upconversion nanoparticles for synergistic chemo-photothermal therapy Wei, Ruoyan; Xi, Wensong; Wang, Haifang Nanoscale, Vol. 9, Issue 35 https://doi.org/10.1039/c7nr02280h	journal	January 2017
Soft X-ray activated NaYF ₄ :Gd/Tb scintillating nanorods for in vivo dual-modal X-ray/X-ray-induced optical bioimaging Li, Xiaolong; Xue, Zhenluan; Jiang, Mingyang Nanoscale, Vol. 10, Issue 1 https://doi.org/10.1039/c7nr02926h	journal	January 2018
Targeted and efficient activation of channelrhodopsins expressed in living cells via specifically-bound upconversion nanoparticles Yadav, Kanchan; Chou, Ai-Chuan; Ulaganathan, Rajesh Kumar Nanoscale, Vol. 9, Issue 27 https://doi.org/10.1039/c7nr03246c	journal	January 2017
Optical nanoprobes for biomedical applications: shining a light on upconverting and near-infrared emitting nanoparticles for imaging, thermal sensing, and photodynamic therapy Hemmer, E.; Acosta-Mora, P.; Méndez-Ramos, J. Journal of Materials Chemistry B, Vol. 5, Issue 23 https://doi.org/10.1039/c7tb00403f	journal	January 2017
Recent progress in upconversion luminescence nanomaterials for biomedical applications Duan, Chengchen; Liang, Liuen; Li, Li Journal of Materials Chemistry B, Vol. 6, Issue 2 https://doi.org/10.1039/c7tb02527k	journal	January 2018
Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation Li, Jingchao; Pu, Kanyi Chemical Society Reviews, Vol. 48, Issue 1 https://doi.org/10.1039/c8cs00001h	journal	January 2019
Upconversion in photodynamic therapy: plumbing the depths Hamblin, Michael R. Dalton Transactions, Vol. 47, Issue 26 https://doi.org/10.1039/c8dt00087e	journal	January 2018
Core–shell rare-earth-doped nanostructures in biomedicine Labrador-Páez, Lucía; Ximendes, Erving C.; Rodríguez-Sevilla, Paloma Nanoscale, Vol. 10, Issue 27 https://doi.org/10.1039/c8nr02307g	journal	January 2018
Self-sensitization induced upconversion of Er ³⁺ in core–shell nanoparticles Yan, Long; Zhou, Bo; Song, Nan Nanoscale, Vol. 10, Issue 37 https://doi.org/10.1039/c8nr04816a	journal	January 2018
Simultaneous enhancement of red upconversion luminescence and CT contrast of NaGdF ₄ :Yb,Er nanoparticles via Lu ³⁺ doping Liu, Miao; Shi, Ziyu; Wang, Xiao Nanoscale, Vol. 10, Issue 43 https://doi.org/10.1039/c8nr06968a	journal	January 2018
In situ reversible color variation of a ready-made upconversion material using the designed component of a three-state fluorescence switching system Zhang, Hui; Zhai, Yiwen; Wang, Min Nanoscale, Vol. 11, Issue 8 https://doi.org/10.1039/c8nr07848c	journal	January 2019
Dye-sensitized upconversion nanocomposites for ratiometric semi-quantitative detection of hypochlorite in vivo Zou, Xianmei; Zhou, Xiaobo; Cao, Cong Nanoscale, Vol. 11, Issue 6 https://doi.org/10.1039/c8nr09531k	journal	January 2019
Enhanced NIR-I emission from water-dispersible NIR-II dye-sensitized core/active shell upconverting nanoparticles Hazra, Chanchal; Ullah, Sajjad; Serge Correales, York E. Journal of Materials Chemistry C, Vol. 6, Issue 17 https://doi.org/10.1039/c8tc00335a	journal	January 2018
Host sensitized intense infrared emissions from Ln ³⁺ doped GdVO ₄ nanocrystals: ranging from 950 nm to 2000 nm Samanta, Tuhin; Praveen, Athma E.; Mahalingam, Venkataramanan Journal of Materials Chemistry C, Vol. 6, Issue 18 https://doi.org/10.1039/c8tc00841h	journal	January 2018
Lighting up Eu ³⁺ luminescence through remote sensitization in silica nanoarchitectures Artizzu, Flavia; Loche, Danilo; Mara, Dimitrije Journal of Materials Chemistry C, Vol. 6, Issue 28 https://doi.org/10.1039/c8tc02097c	journal	January 2018
In vivo clearable inorganic nanophotonic materials: designs, materials and applications Nie, Jianmin; Li, Yang; Han, Gang Nanoscale, Vol. 11, Issue 27 https://doi.org/10.1039/c9nr02083g	journal	January 2019
Yb,Nd,Er-doped upconversion nanoparticles: 980 nm versus 808 nm excitation Wiesholler, Lisa M.; Frenzel, Florian; Grauel, Bettina Nanoscale, Vol. 11, Issue 28 https://doi.org/10.1039/c9nr03127h	journal	January 2019
Flexible and fully implantable upconversion device for wireless optogenetic stimulation of the spinal cord in behaving animals Wang, Ying; Xie, Kai; Yue, Haibing Nanoscale, Vol. 12, Issue 4 https://doi.org/10.1039/c9nr07583f	journal	January 2020
Prussian blue-coated lanthanide-doped core/shell/shell nanocrystals for NIR-II image-guided photothermal therapy Wang, Xin; Li, Hui; Li, Feng Nanoscale, Vol. 11, Issue 45 https://doi.org/10.1039/c9nr07973d	journal	January 2019
Upconversion-mediated ZnFe ₂ O ₄ nanoplatform for NIR-enhanced chemodynamic and photodynamic therapy Dong, Shuming; Xu, Jiating; Jia, Tao Chemical Science, Vol. 10, Issue 15 https://doi.org/10.1039/c9sc00387h	journal	January 2019
Regulating the color output and simultaneously enhancing the intensity of upconversion nanoparticles via a dye sensitization strategy Xue, Bin; Wang, Dan; Zhang, Youlin Journal of Materials Chemistry C, Vol. 7, Issue 28 https://doi.org/10.1039/c9tc02293g	journal	January 2019
Pick your precursor! Tailoring the size and crystal phase of microwave-synthesized sub-10 nm upconverting nanoparticles Halimi, Ilias; Rodrigues, Emille M.; Maurizio, Steven L. Journal of Materials Chemistry C, Vol. 7, Issue 48 https://doi.org/10.1039/c9tc04817k	journal	January 2019
Accurate manipulation of optogenetic proteins with wavelength tunable femtosecond laser system Ji, Wanying; Wang, Shaoyang; Zhao, Jun Journal of Applied Physics, Vol. 125, Issue 16 https://doi.org/10.1063/1.5084197	journal	April 2019
Expanding the toolbox for lanthanide-doped upconversion nanocrystals Wu, Yiming; Ang, Melgious Jin Yan; Sun, Mingzi Journal of Physics D: Applied Physics, Vol. 52, Issue 38 https://doi.org/10.1088/1361-6463/ab29c7	journal	July 2019
Enhanced upconversion luminescence intensity of core–shell NaYF ₄ nanocrystals guided by morphological control Kang, Ning; Zhao, Jie; Zhou, Yaming Nanotechnology, Vol. 30, Issue 10 https://doi.org/10.1088/1361-6528/aafb19	journal	January 2019
Sensitization of upconverting nanoparticles with a NIR-emissive cyanine dye using a micellar encapsulation approach Saleh, Maysoon I.; Panas, Ihor D.; Frenzel, Florian Methods and Applications in Fluorescence, Vol. 7, Issue 1 https://doi.org/10.1088/2050-6120/aafe1f	journal	January 2019
Enhancing generating and collecting efficiency of single particle upconverting luminescence at low-level power excitation Ma, Chenshuo; Shan, Chunyan; Park, Kevin Nanophotonics https://doi.org/10.1101/2019.12.17.879858	journal	December 2019
Remote control of neural function by X-ray-induced scintillation Matsubara, Takanori; Yanagida, Takayuki; Kawaguchi, Noriaki Nature Communications https://doi.org/10.1101/798702	journal	November 2020
Next-generation probes, particles, and proteins for neural interfacing Rivnay, Jonathan; Wang, Huiliang; Fenno, Lief Science Advances, Vol. 3, Issue 6 https://doi.org/10.1126/sciadv.1601649	journal	June 2017
Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics Chen, Shuo; Weitemier, Adam Z.; Zeng, Xiao Science, Vol. 359, Issue 6376 https://doi.org/10.1126/science.aaq1144	journal	February 2018
UCNPs@Zn _0.5 Cd _0.5 S Core-Shell and Yolk-Shell Nanostructures: Selective Synthesis, Characterization, and Near-Infrared-Mediated Photocatalytic Reduction of Cr(VI) Wang, Wan-Ni; Dong, Wang; Huang, Chen-Xi Journal of Nanomaterials, Vol. 2018 https://doi.org/10.1155/2018/1293847	journal	September 2018
Plasmon-enhanced upconversion: engineering enhancement and quenching at nano and macro scales Rasskazov, Ilia L.; Wang, Lang; Murphy, Catherine J. Optical Materials Express, Vol. 8, Issue 12 https://doi.org/10.1364/ome.8.003787	journal	January 2018
Factors relating to the biodistribution & clearance of nanoparticles & their effects on in vivo application Wei, Yanchun; Quan, Li; Zhou, Chao Nanomedicine, Vol. 13, Issue 12 https://doi.org/10.2217/nnm-2018-0040	journal	June 2018
The Impact of Optogenetics on Regenerative Medicine Spagnuolo, Gianrico; Genovese, Fabio; Fortunato, Leonzio Applied Sciences, Vol. 10, Issue 1 https://doi.org/10.3390/app10010173	journal	December 2019

Similar Records

Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications

Journal Article · Mon Jan 25 23:00:00 EST 2016 · ACS Nano · OSTI ID:1337277

Modulating upconversion luminescence through fluorescent dyes

Journal Article · Tue Nov 14 23:00:00 EST 2017 · Journal of Solid State Chemistry · OSTI ID:22742058

Triplet-Induced Singlet Oxygen Photobleaches Near-Infrared Dye-Sensitized Upconversion Nanosystems

Journal Article · Wed Jul 26 00:00:00 EDT 2023 · Nano Letters · OSTI ID:2326958

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
77 NANOSCIENCE AND NANOTECHNOLOGY
bioimaging
core/active shell structure
dye-sensitizing
near-infrared
optogenetics
upconversion nanoparticles

Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications

Citation Formats

References (43)

Cited By (97)

Similar Records

Related Subjects