Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications

Wu, Xiang; Zhang, Yuanwei; Takle, Kendra; Bilsel, Osman; Li, Zhanjun; Lee, Hyungseok; Zhang, Zijiao; Li, Dongsheng; Fan, Wei; Duan, Chunying; Chan, Emory M.; Lois, Carlos; Xiang, Yang; Han, Gang

doi:10.1021/acsnano.5b06383

Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications

Journal Article · Tue Jan 26 04:00:00 EST 2016 · ACS Nano

DOI:https://doi.org/10.1021/acsnano.5b06383· OSTI ID:1337277

Wu, Xiang; Zhang, Yuanwei; Takle, Kendra; Bilsel, Osman; Li, Zhanjun; Lee, Hyungseok; Zhang, Zijiao; Li, Dongsheng; Fan, Wei; Duan, Chunying; Chan, Emory M.; Lois, Carlos; Xiang, Yang; Han, Gang

Near Infrared (NIR) dye-sensitized upconversion nanoparticles (UCNPs) have recently been proposed in order to broaden the absorption range and to boost upconversion efficiency. However, implementing this strategy has been limited only to bare core UCNP structures that are faintly luminescent. Herein, we report on an approach to achieve significantly enhanced upconversion luminescence in dye-sensitized core-active shell UCNPs with a broadened absorption range via the doping of ytterbium ions in the UCNP shell in order to bridge the energy transfer from the dye to the UCNP core. As a result, we have been able to synergize the two most practical upconversion booster effectors (dye-sensitizing and core/shell enhancement). The absolute quantum yield of our dye-sensitized core/active shell UCNPs at 800 nm was determined to be ~6% at 2 W/cm2, about 33 times larger than the highest value reported to date for existing 800 nm excitable UCNPs. Moreover, for the first time, by using dye-sensitized core/active shell UCNP embedded poly(methyl methacrylate) polymer implantable systems, we successfully shifted the optogenetic neuron excitation window to a wavelength that is compatible with deep tissue penetrable near the infrared wavelength at 800 nm. Finally, amphiphilic triblock copolymer, Pluronic F127 coatings permit the transfer of hydrophobic UCNPs into water, resulting in water-soluble nanoparticles with well-preserved optical property in aqueous solution. We believe that this research offers a new solution to enhance upconversion efficiency for photonic and biophotonic purposes and opens up new opportunities to use UCNPs as a NIR relay for optogenetic applications.

Research Organization:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

DOE Contract Number:: AC05-76RL01830

OSTI ID:: 1337277

Report Number(s):: PNNL-SA--115307

Journal Information:: ACS Nano, Journal Name: ACS Nano Journal Issue: 1 Vol. 10; ISSN 1936-0851

Publisher:: American Chemical Society (ACS)

Country of Publication:: United States

Language:: English

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