Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications

Wu, Xiang; Zhang, Yuanwei; Takle, Kendra; Bilsel, Osman; Li, Zhanjun; Lee, Hyungseok; Zhang, Zijiao; Li, Dongsheng; Fan, Wei; Duan, Chunying; Chan, Emory M.; Lois, Carlos; Xiang, Yang; Han, Gang

doi:10.1021/acsnano.5b06383

Title: Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications

Journal Article · Tue Jan 26 00:00:00 EST 2016 · ACS Nano

DOI:https://doi.org/10.1021/acsnano.5b06383· OSTI ID:1337277

Wu, Xiang; Zhang, Yuanwei; Takle, Kendra; Bilsel, Osman; Li, Zhanjun; Lee, Hyungseok; Zhang, Zijiao; Li, Dongsheng; Fan, Wei; Duan, Chunying; Chan, Emory M.; Lois, Carlos; Xiang, Yang; Han, Gang

Near Infrared (NIR) dye-sensitized upconversion nanoparticles (UCNPs) have recently been proposed in order to broaden the absorption range and to boost upconversion efficiency. However, implementing this strategy has been limited only to bare core UCNP structures that are faintly luminescent. Herein, we report on an approach to achieve significantly enhanced upconversion luminescence in dye-sensitized core-active shell UCNPs with a broadened absorption range via the doping of ytterbium ions in the UCNP shell in order to bridge the energy transfer from the dye to the UCNP core. As a result, we have been able to synergize the two most practical upconversion booster effectors (dye-sensitizing and core/shell enhancement). The absolute quantum yield of our dye-sensitized core/active shell UCNPs at 800 nm was determined to be ~6% at 2 W/cm2, about 33 times larger than the highest value reported to date for existing 800 nm excitable UCNPs. Moreover, for the first time, by using dye-sensitized core/active shell UCNP embedded poly(methyl methacrylate) polymer implantable systems, we successfully shifted the optogenetic neuron excitation window to a wavelength that is compatible with deep tissue penetrable near the infrared wavelength at 800 nm. Finally, amphiphilic triblock copolymer, Pluronic F127 coatings permit the transfer of hydrophobic UCNPs into water, resulting in water-soluble nanoparticles with well-preserved optical property in aqueous solution. We believe that this research offers a new solution to enhance upconversion efficiency for photonic and biophotonic purposes and opens up new opportunities to use UCNPs as a NIR relay for optogenetic applications.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

DOE Contract Number:: AC05-76RL01830

OSTI ID:: 1337277

Report Number(s):: PNNL-SA-115307

Journal Information:: ACS Nano, Vol. 10, Issue 1; ISSN 1936-0851

Publisher:: American Chemical Society (ACS)

Country of Publication:: United States

Language:: English

References (42)

The Development and Application of Optogenetics Fenno, Lief; Yizhar, Ofer; Deisseroth, Karl Annual Review of Neuroscience, Vol. 34, Issue 1 https://doi.org/10.1146/annurev-neuro-061010-113817	journal	July 2011
Multimodal fast optical interrogation of neural circuitry Zhang, Feng; Wang, Li-Ping; Brauner, Martin Nature, Vol. 446, Issue 7136 https://doi.org/10.1038/nature05744	journal	April 2007
Millisecond-timescale, genetically targeted optical control of neural activity Boyden, Edward S.; Zhang, Feng; Bamberg, Ernst Nature Neuroscience, Vol. 8, Issue 9 https://doi.org/10.1038/nn1525	journal	August 2005
Implanted Neural Interfaces: Biochallenges and Engineered Solutions Grill, Warren M.; Norman, Sharon E.; Bellamkonda, Ravi V. Annual Review of Biomedical Engineering, Vol. 11, Issue 1 https://doi.org/10.1146/annurev-bioeng-061008-124927	journal	August 2009
Remote control of ion channels and neurons through magnetic-field heating of nanoparticles Huang, Heng; Delikanli, Savas; Zeng, Hao Nature Nanotechnology, Vol. 5, Issue 8 https://doi.org/10.1038/nnano.2010.125	journal	June 2010
Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics McCall, Jordan G.; Kim, Tae-il; Shin, Gunchul Nature Protocols, Vol. 8, Issue 12, p. 2413-2428 https://doi.org/10.1038/nprot.2013.158	journal	November 2013
Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics Kim, T.-i.; McCall, J. G.; Jung, Y. H. Science, Vol. 340, Issue 6129, p. 211-216 https://doi.org/10.1126/science.1232437	journal	April 2013
ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation Lin, John Y.; Knutsen, Per Magne; Muller, Arnaud Nature Neuroscience, Vol. 16, Issue 10 https://doi.org/10.1038/nn.3502	journal	September 2013
Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction Shi Kam, N. W.; O'Connell, M.; Wisdom, J. A. Proceedings of the National Academy of Sciences, Vol. 102, Issue 33, p. 11600-11605 https://doi.org/10.1073/pnas.0502680102	journal	August 2005
Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy Punjabi, Amol; Wu, Xiang; Tokatli-Apollon, Amira ACS Nano, Vol. 8, Issue 10 https://doi.org/10.1021/nn505051d	journal	October 2014
Upconverting Nanoparticles Haase, Markus; Schäfer, Helmut Angewandte Chemie International Edition, Vol. 50, Issue 26 https://doi.org/10.1002/anie.201005159	journal	May 2011
Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals Wang, Feng; Liu, Xiaogang Chemical Society Reviews, Vol. 38, Issue 4 https://doi.org/10.1039/b809132n	journal	January 2009
Sub-10 nm Hexagonal Lanthanide-Doped NaLuF ₄ Upconversion Nanocrystals for Sensitive Bioimaging in Vivo Liu, Qian; Sun, Yun; Yang, Tianshe Journal of the American Chemical Society, Vol. 133, Issue 43 https://doi.org/10.1021/ja207078s	journal	November 2011
(α-NaYbF ₄ :Tm ³⁺ )/CaF ₂ Core/Shell Nanoparticles with Efficient Near-Infrared to Near-Infrared Upconversion for High-Contrast Deep Tissue Bioimaging Chen, Guanying; Shen, Jie; Ohulchanskyy, Tymish Y. ACS Nano, Vol. 6, Issue 9 https://doi.org/10.1021/nn302972r	journal	August 2012
Upconversion Nanoparticles: A Versatile Solution to Multiscale Biological Imaging Wu, Xiang; Chen, Guanying; Shen, Jie Bioconjugate Chemistry, Vol. 26, Issue 2 https://doi.org/10.1021/bc5003967	journal	October 2014
Current advances in lanthanide ion (Ln ³⁺ )-based upconversion nanomaterials for drug delivery Yang, Dongmei; Ma, Ping'an; Hou, Zhiyou Chemical Society Reviews, Vol. 44, Issue 6 https://doi.org/10.1039/C4CS00155A	journal	January 2015
Lanthanide-doped upconverting luminescent nanoparticle platforms for optical imaging-guided drug delivery and therapy Shen, Jie; Zhao, Liang; Han, Gang Advanced Drug Delivery Reviews, Vol. 65, Issue 5 https://doi.org/10.1016/j.addr.2012.05.007	journal	May 2013
Upconversion nanoparticles as versatile light nanotransducers for photoactivation applications Idris, Niagara Muhammad; Jayakumar, Muthu Kumara Gnanasammandhan; Bansal, Akshaya Chemical Society Reviews, Vol. 44, Issue 6 https://doi.org/10.1039/C4CS00158C	journal	January 2015
Protein modified upconversion nanoparticles for imaging-guided combined photothermal and photodynamic therapy Chen, Qian; Wang, Chao; Cheng, Liang Biomaterials, Vol. 35, Issue 9 https://doi.org/10.1016/j.biomaterials.2013.12.046	journal	March 2014
Antigen-Loaded Upconversion Nanoparticles for Dendritic Cell Stimulation, Tracking, and Vaccination in Dendritic Cell-Based Immunotherapy Xiang, Jian; Xu, Ligeng; Gong, Hua ACS Nano, Vol. 9, Issue 6 https://doi.org/10.1021/acsnano.5b02014	journal	May 2015
Remote activation of biomolecules in deep tissues using near-infrared-to-UV upconversion nanotransducers Jayakumar, M. K. G.; Idris, N. M.; Zhang, Y. Proceedings of the National Academy of Sciences, Vol. 109, Issue 22 https://doi.org/10.1073/pnas.1114551109	journal	May 2012
In Vitro and In Vivo Uncaging and Bioluminescence Imaging by Using Photocaged Upconversion Nanoparticles Yang, Yanmei; Shao, Qing; Deng, Renren Angewandte Chemie International Edition, Vol. 51, Issue 13 https://doi.org/10.1002/anie.201107919	journal	January 2012
Upconversion: Tunable Near Infrared to Ultraviolet Upconversion Luminescence Enhancement in (α-NaYF ₄ :Yb,Tm)/CaF ₂ Core/Shell Nanoparticles for In situ Real-time Recorded Biocompatible Photoactivation (Small 19/2013) Shen, Jie; Chen, Guanying; Ohulchanskyy, Tymish Y. Small, Vol. 9, Issue 19 https://doi.org/10.1002/smll.201370117	journal	October 2013
Rare-Earth Ion Doped Up-Conversion Materials for Photovoltaic Applications Wang, Hai-Qiao; Batentschuk, Miroslaw; Osvet, Andres Advanced Materials, Vol. 23, Issue 22-23 https://doi.org/10.1002/adma.201100511	journal	April 2011
Quantitative analysis of transcranial and intraparenchymal light penetration in human cadaver brain tissue: TRANSCRANIAL AND INTRAPARENCHYMAL LIGHT PENETRATION Tedford, Clark E.; DeLapp, Scott; Jacques, Steven Lasers in Surgery and Medicine, Vol. 47, Issue 4 https://doi.org/10.1002/lsm.22343	journal	March 2015
Enhancing Luminescence in Lanthanide-Doped Upconversion Nanoparticles Han, Sanyang; Deng, Renren; Xie, Xiaoji Angewandte Chemie International Edition, Vol. 53, Issue 44 https://doi.org/10.1002/anie.201403408	journal	September 2014
Theranostic Upconversion Nanoparticles (I) Chen, Guanying; Han, Gang Theranostics, Vol. 3, Issue 4 https://doi.org/10.7150/thno.6382	journal	January 2013
Rationally Designed Energy Transfer in Upconverting Nanoparticles Chan, Emory M.; Levy, Elizabeth S.; Cohen, Bruce E. Advanced Materials, Vol. 27, Issue 38 https://doi.org/10.1002/adma.201500248	journal	March 2015
Photon upconversion in core–shell nanoparticles Chen, Xian; Peng, Denfeng; Ju, Qiang Chemical Society Reviews, Vol. 44, Issue 6 https://doi.org/10.1039/C4CS00151F	journal	January 2015
Direct Evidence of a Surface Quenching Effect on Size-Dependent Luminescence of Upconversion Nanoparticles Wang, Feng; Wang, Juan; Liu, Xiaogang Angewandte Chemie International Edition, Vol. 49, Issue 41 https://doi.org/10.1002/anie.201003959	journal	August 2010
Engineering the Upconversion Nanoparticle Excitation Wavelength: Cascade Sensitization of Tri-doped Upconversion Colloidal Nanoparticles at 800 nm Shen, Jie; Chen, Guanying; Vu, Anne-Marie Advanced Optical Materials, Vol. 1, Issue 9 https://doi.org/10.1002/adom.201300160	journal	July 2013
Nd ³⁺ -Sensitized Upconversion Nanophosphors: Efficient In Vivo Bioimaging Probes with Minimized Heating Effect Wang, Ye-Fu; Liu, Gao-Yuan; Sun, Ling-Dong ACS Nano, Vol. 7, Issue 8 https://doi.org/10.1021/nn402601d	journal	July 2013
Upconversion goes broadband Xie, Xiaoji; Liu, Xiaogang Nature Materials, Vol. 11, Issue 10 https://doi.org/10.1038/nmat3426	journal	September 2012
Broadband dye-sensitized upconversion of near-infrared light Zou, Wenqiang; Visser, Cindy; Maduro, Jeremio A. Nature Photonics, Vol. 6, Issue 8 https://doi.org/10.1038/nphoton.2012.158	journal	July 2012
High-Quality Sodium Rare-Earth Fluoride Nanocrystals: Controlled Synthesis and Optical Properties Mai, Hao-Xin; Zhang, Ya-Wen; Si, Rui Journal of the American Chemical Society, Vol. 128, Issue 19 https://doi.org/10.1021/ja060212h	journal	May 2006
The Active-Core/Active-Shell Approach: A Strategy to Enhance the Upconversion Luminescence in Lanthanide-Doped Nanoparticles Vetrone, Fiorenzo; Naccache, Rafik; Mahalingam, Venkataramanan Advanced Functional Materials, Vol. 19, Issue 18 https://doi.org/10.1002/adfm.200900234	journal	September 2009
Colloidal synthesis and remarkable enhancement of the upconversion luminescence of BaGdF5:Yb3+/Er3+ nanoparticles by active-shell modification Yang, Dongmei; Li, Chunxia; Li, Guogang Journal of Materials Chemistry, Vol. 21, Issue 16 https://doi.org/10.1039/c0jm04179c	journal	January 2011
Poly(Acrylic Acid) Modification of Nd ³⁺ -Sensitized Upconversion Nanophosphors for Highly Efficient UCL Imaging and pH-Responsive Drug Delivery Liu, Bei; Chen, Yinyin; Li, Chunxia Advanced Functional Materials, Vol. 25, Issue 29 https://doi.org/10.1002/adfm.201501582	journal	June 2015
In-Depth Activation of Channelrhodopsin 2-Sensitized Excitable Cells with High Spatial Resolution Using Two-Photon Excitation with a Near-Infrared Laser Microbeam Mohanty, Samarendra K.; Reinscheid, Rainer K.; Liu, Xiaobin Biophysical Journal, Vol. 95, Issue 8 https://doi.org/10.1529/biophysj.108.130187	journal	October 2008
Scanless two-photon excitation of channelrhodopsin-2 Papagiakoumou, Eirini; Anselmi, Francesca; Bègue, Aurélien Nature Methods, Vol. 7, Issue 10 https://doi.org/10.1038/nmeth.1505	journal	September 2010
Encapsulation of Hydrophobic Drugs in Pluronic F127 Micelles: Effects of Drug Hydrophobicity, Solution Temperature, and pH Basak, Rajib; Bandyopadhyay, Ranjini Langmuir, Vol. 29, Issue 13 https://doi.org/10.1021/la304836e	journal	February 2013
Bioconjugated Pluronic Triblock-Copolymer Micelle-Encapsulated Quantum Dots for Targeted Imaging of Cancer: In Vitro and In Vivo Studies Liu, Liwei; Yong, Ken-Tye; Roy, Indrajit Theranostics, Vol. 2, Issue 7 https://doi.org/10.7150/thno.3456	journal	January 2012

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Enrichment of molecular antenna triplets amplifies upconverting nanoparticle emission Garfield, David J.; Borys, Nicholas J.; Hamed, Samia M. Nature Photonics, Vol. 12, Issue 7 https://doi.org/10.1038/s41566-018-0156-x	journal	April 2018
Intracellular localization of nanoparticle dimers by chirality reversal Sun, Maozhong; Xu, Liguang; Bahng, Joong Hwan Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/s41467-017-01337-2	journal	November 2017
Expanding the Toolbox of Upconversion Nanoparticles for In Vivo Optogenetics and Neuromodulation All, Angelo Homayoun; Zeng, Xiao; Teh, Daniel Boon Loong Advanced Materials, Vol. 31, Issue 41 https://doi.org/10.1002/adma.201803474	journal	August 2019
Achieving high-efficiency emission depletion nanoscopy by employing cross relaxation in upconversion nanoparticles Zhan, Qiuqiang; Liu, Haichun; Wang, Baoju Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/s41467-017-01141-y	journal	October 2017
The Impact of Optogenetics on Regenerative Medicine Spagnuolo, Gianrico; Genovese, Fabio; Fortunato, Leonzio Applied Sciences, Vol. 10, Issue 1 https://doi.org/10.3390/app10010173	journal	December 2019
Yb,Nd,Er-doped upconversion nanoparticles: 980 nm versus 808 nm excitation Wiesholler, Lisa M.; Frenzel, Florian; Grauel, Bettina Nanoscale, Vol. 11, Issue 28 https://doi.org/10.1039/c9nr03127h	journal	January 2019
Lanthanide Doped Near Infrared Active Upconversion Nanophosphors: Fundamental Concepts, Synthesis Strategies, and Technological Applications Lingeshwar Reddy, Kumbam; Balaji, Ramachandran; Kumar, Ashish Small, Vol. 14, Issue 37 https://doi.org/10.1002/smll.201801304	journal	July 2018
Luminescent Ions in Advanced Composite Materials for Multifunctional Applications Bai, Gongxun; Tsang, Ming-Kiu; Hao, Jianhua Advanced Functional Materials, Vol. 26, Issue 35 https://doi.org/10.1002/adfm.201602142	journal	July 2016
Remote control of neural function by X-ray-induced scintillation Matsubara, Takanori; Yanagida, Takayuki; Kawaguchi, Noriaki Nature Communications https://doi.org/10.1101/798702	journal	November 2020
Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation Li, Jingchao; Pu, Kanyi Chemical Society Reviews, Vol. 48, Issue 1 https://doi.org/10.1039/c8cs00001h	journal	January 2019
Upconversion superballs for programmable photoactivation of therapeutics Zhang, Zhen; Jayakumar, Muthu Kumara Gnanasammandhan; Zheng, Xiang Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-12506-w	journal	October 2019
808-nm-Light-Excited Lanthanide-Doped Nanoparticles: Rational Design, Luminescence Control and Theranostic Applications Liu, Bei; Li, Chunxia; Yang, Piaoping Advanced Materials, Vol. 29, Issue 18 https://doi.org/10.1002/adma.201605434	journal	March 2017
Band Gap Engineering Improves the Efficiency of Double Quantum Dot Upconversion Nanocrystals Yang, Gaoling; Meir, Noga; Raanan, Dekel Advanced Functional Materials, Vol. 29, Issue 23 https://doi.org/10.1002/adfm.201900755	journal	April 2019
Photophysics of Up‐Conversion Nanoparticles: Radical Photopolymerization of Multifunctional Methacrylates Comprising Blue‐ and UV‐Sensitive Photoinitiators Oprych, Dennis; Schmitz, Christian; Ley, Christian ChemPhotoChem, Vol. 3, Issue 11 https://doi.org/10.1002/cptc.201900196	journal	August 2019
Photon Upconversion Kinetic Nanosystems and Their Optical Response: Photon Upconversion Kinetic Nanosystems and Their Optical Response Liu, Haichun; Huang, Kai; Valiev, Rashid R. Laser & Photonics Reviews, Vol. 12, Issue 1 https://doi.org/10.1002/lpor.201700144	journal	November 2017
Enhanced upconversion luminescence intensity of core–shell NaYF ₄ nanocrystals guided by morphological control Kang, Ning; Zhao, Jie; Zhou, Yaming Nanotechnology, Vol. 30, Issue 10 https://doi.org/10.1088/1361-6528/aafb19	journal	January 2019
Up-Conversion Fluorescent Labels for Plastic Recycling: A Review Gao, Guojun; Turshatov, Andrey; Howard, Ian A. Advanced Sustainable Systems, Vol. 1, Issue 5 https://doi.org/10.1002/adsu.201600033	journal	May 2017
Upconversion amplification through dielectric superlensing modulation Liang, Liangliang; Teh, Daniel B. L.; Dinh, Ngoc-Duy Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-09345-0	journal	March 2019
Core–shell rare-earth-doped nanostructures in biomedicine Labrador-Páez, Lucía; Ximendes, Erving C.; Rodríguez-Sevilla, Paloma Nanoscale, Vol. 10, Issue 27 https://doi.org/10.1039/c8nr02307g	journal	January 2018
NIR Biosensing of Neurotransmitters in Stem Cell‐Derived Neural Interface Using Advanced Core–Shell Upconversion Nanoparticles Rabie, Hudifah; Zhang, Yixiao; Pasquale, Nicholas Advanced Materials, Vol. 31, Issue 14 https://doi.org/10.1002/adma.201806991	journal	February 2019
Boosting Luminance Energy Transfer Efficiency in Upconversion Nanoparticles with an Energy‐Concentrating Zone Zhang, Xiaobo; Chen, Weiwei; Xie, Xiaoyu Angewandte Chemie, Vol. 131, Issue 35 https://doi.org/10.1002/ange.201906380	journal	July 2019
Advances in highly doped upconversion nanoparticles Wen, Shihui; Zhou, Jiajia; Zheng, Kezhi Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-04813-5	journal	June 2018
In situ crystal growth of gold nanocrystals on upconversion nanoparticles for synergistic chemo-photothermal therapy Wei, Ruoyan; Xi, Wensong; Wang, Haifang Nanoscale, Vol. 9, Issue 35 https://doi.org/10.1039/c7nr02280h	journal	January 2017
Enhanced NIR-I emission from water-dispersible NIR-II dye-sensitized core/active shell upconverting nanoparticles Hazra, Chanchal; Ullah, Sajjad; Serge Correales, York E. Journal of Materials Chemistry C, Vol. 6, Issue 17 https://doi.org/10.1039/c8tc00335a	journal	January 2018
Lighting up Eu ³⁺ luminescence through remote sensitization in silica nanoarchitectures Artizzu, Flavia; Loche, Danilo; Mara, Dimitrije Journal of Materials Chemistry C, Vol. 6, Issue 28 https://doi.org/10.1039/c8tc02097c	journal	January 2018
Prussian blue-coated lanthanide-doped core/shell/shell nanocrystals for NIR-II image-guided photothermal therapy Wang, Xin; Li, Hui; Li, Feng Nanoscale, Vol. 11, Issue 45 https://doi.org/10.1039/c9nr07973d	journal	January 2019
Accurate manipulation of optogenetic proteins with wavelength tunable femtosecond laser system Ji, Wanying; Wang, Shaoyang; Zhao, Jun Journal of Applied Physics, Vol. 125, Issue 16 https://doi.org/10.1063/1.5084197	journal	April 2019
Next-generation probes, particles, and proteins for neural interfacing Rivnay, Jonathan; Wang, Huiliang; Fenno, Lief Science Advances, Vol. 3, Issue 6 https://doi.org/10.1126/sciadv.1601649	journal	June 2017
Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery Han, Sanyang; Samanta, Animesh; Xie, Xiaoji Advanced Materials, Vol. 29, Issue 40 https://doi.org/10.1002/adma.201704811	journal	October 2017
Lanthanide-Doped Upconversion Nanoparticles: Emerging Intelligent Light-Activated Drug Delivery Systems Bagheri, Ali; Arandiyan, Hamidreza; Boyer, Cyrille Advanced Science, Vol. 3, Issue 7 https://doi.org/10.1002/advs.201500437	journal	March 2016
A Universal Strategy to Construct Lanthanide-Doped Nanoparticles-Based Activable NIR-II Luminescence Probe for Bioimaging Li, Zhen; Wu, Junjie; Wang, Qirong iScience, Vol. 23, Issue 3 https://doi.org/10.1016/j.isci.2020.100962	journal	March 2020
Dye-Sensitized Downconversion Wang, Zijun; Meijerink, Andries The Journal of Physical Chemistry Letters, Vol. 9, Issue 7 https://doi.org/10.1021/acs.jpclett.8b00516	journal	March 2018
Recent Development of Inorganic Nanoparticles for Biomedical Imaging Kim, Dokyoon; Kim, Jonghoon; Park, Yong Il ACS Central Science, Vol. 4, Issue 3 https://doi.org/10.1021/acscentsci.7b00574	journal	January 2018
Upconversion nanocomposite for programming combination cancer therapy by precise control of microscopic temperature Zhu, Xingjun; Li, Jiachang; Qiu, Xiaochen Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-04571-4	journal	June 2018
Co-delivery of brinzolamide and miRNA-124 by biodegradable nanoparticles as a strategy for glaucoma therapy Li, Tingting; Wang, Ye; Chen, Jiahao Drug Delivery, Vol. 27, Issue 1 https://doi.org/10.1080/10717544.2020.1731861	journal	January 2020
The nanomaterial toolkit for neuroengineering Shah, Shreyas Nano Convergence, Vol. 3, Issue 1 https://doi.org/10.1186/s40580-016-0086-6	journal	October 2016
Construction of Multicolor Upconversion Nanotheranostic Agent for in-situ Cooperative Photodynamic Therapy for Deep-Seated Malignant Tumors Hong, Tongtong; Jiang, Yanxialei; Yue, Zihong Frontiers in Chemistry, Vol. 8 https://doi.org/10.3389/fchem.2020.00052	journal	February 2020
Simultaneous Dual-mode Emission and Tunable Multicolor in the Time Domain from Lanthanide-doped Core-shell Microcrystals Ju, Dandan; Song, Feng; Khan, Adnan Nanomaterials, Vol. 8, Issue 12 https://doi.org/10.3390/nano8121023	journal	December 2018

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