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Evaluation of Infectivity, Virulence and Transmission of FDMV Field Strains of Serotypes O and A Isolated In 2010 from Outbreaks in the Republic of Korea

Journal Article · · PLoS ONE
 [1];  [2];  [3];  [1];  [1];  [1];  [1];  [2];  [2];  [2];  [2];  [2];  [2];  [2];  [1];  [1];  [4]
  1. United States Dept. of Agriculture, Plum Island, NY (United States)
  2. Animal and Plant Quarantine Agency, Gyeonggi-do (Republic of Korea)
  3. United States Dept. of Agriculture, Plum Island, NY (United States); Oak Ridge Institute for Science and Education, Oak Ridge, TN (United States)
  4. The Pirbright Institute (United Kingdom)
+ Show Author Affiliations
Since the early 2000s outbreaks of foot-and-mouth disease (FMD) have been described in several previously FMD-free Asian nations, including the Republic of Korea (South Korea). One outbreak with FMD virus (FDMV) serotype A and two with serotype O occurred in South Korea in 2010/2011. The causative viruses belonged to lineages that had been spreading in South East Asia, far East and East Asia since 2009 and presented a great threat to the countries in that region. Most FMDV strains infect ruminants and pigs, as it happened during the outbreaks of FMDV serotype O in South Korea. Contrastingly, the strain of serotype A affected only ruminants. Based upon these findings, the intention of the work described in the current report was to characterize and compare the infectivity, virulence and transmission of both strains under laboratory conditions in cattle and pigs, by direct inoculation and contact exposure. As expected, FMDV serotype O was highly virulent in both cattle and swine by contact exposure and direct inoculation. Surprisingly, FMDV serotype A was highly virulent in swine, but was less infectious in cattle by contact exposure to infected swine or cattle. Interestingly, similar quantities of aerosolized FMDV RNA were detected during experiments with viruses of serotypes O and A. Here, specific virus-host interaction of A/SKR/2010 could affect the transmission of this strain to cattle, and this may explain in part the limited spread of the serotype A epizootic
Research Organization:
Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI ID:
1376849
Journal Information:
PLoS ONE, Journal Name: PLoS ONE Journal Issue: 1 Vol. 11; ISSN 1932-6203
Publisher:
Public Library of ScienceCopyright Statement
Country of Publication:
United States
Language:
English

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Cited By (4)

Virulence beneath the fleece; a tale of foot-and-mouth disease virus pathogenesis in sheep journal December 2019
The Pathogenesis of Foot-and-Mouth Disease in Pigs journal May 2016
Parameterization of the Durations of Phases of Foot-And-Mouth Disease in Cattle journal August 2019
Endemic foot and mouth disease: pastoral in-herd disease dynamics in sub-Saharan Africa journal November 2019

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
RNA viruses
South Korea
cattle
foot and mouth disease
livestock
swine
vesicles
viremia