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Title: HIV-1 envelope glycoprotein

Patent ·
OSTI ID:1376215
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The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization, electron microscopy and other biophysical, biochemical and immunological studies for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions, which are formulated into the vaccines of the present invention.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-06CH11357
Assignee:
INTERNATIONAL AIDS VACCINE INITIATIVE
Patent Number(s):
9,738,688
Application Number:
14/072,209
OSTI ID:
1376215
Resource Relation:
Patent File Date: 2013 Nov 05
Country of Publication:
United States
Language:
English

References (8)

Human immunodeficiency virus envelope clycoprotein mutants and uses thereof patent-application April 2005
HIV vaccines based on Env of multiple clades of HIV patent-application December 2006
Hiv-1 Neutralizing Antibodies Elicited By Trimeric Hiv-1 Envelope Glycoprotein Complex patent-application November 2008
Specific amino acids in the N-terminus of the gp41 ectodomain contribute to the stabilization of a soluble, cleaved gp140 envelope glycoprotein from human immunodeficiency virus type 1 journal March 2007
Construction and Characterization of Soluble, Cleaved, and Stabilized Trimeric Env Proteins Based on HIV Type 1 Env Subtype A journal June 2006
Identification of a clade A HIV envelope immunogen from Protocol G that elicits neutralizing antibodies to tier 2 viruses journal January 2012
A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells journal June 2011
A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies journal September 2013

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