Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO–PPO–PEO triblock copolymers [Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO PPO PEO triblock copolymers]

Rahman, Masoud; Yu, Erick; Forman, Evan; Roberson-Mailloux, Cameron; Tung, Jonathan; Tringe, Joseph; Stroeve, Pieter

doi:10.1016/j.colsurfb.2014.08.013

Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO–PPO–PEO triblock copolymers [Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO PPO PEO triblock copolymers]

Journal Article · Wed Aug 20 00:00:00 EDT 2014 · Colloids and Surfaces. B, Biointerfaces

DOI:https://doi.org/10.1016/j.colsurfb.2014.08.013· OSTI ID:1376015

^[1]; Yu, Erick ^[1]; Forman, Evan ^[1]; Roberson-Mailloux, Cameron ^[1]; Tung, Jonathan ^[1]; Tringe, Joseph ^[2]; ^[1]

Univ. of California, Davis, CA (United States). Dept. of Chemical Engineering and Materials Science
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

Triblock copolymers comprised of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO, or trade name Pluronic) interact with lipid bilayers to increase their permeability. Here we demonstrate a novel application of Pluronic L61 and L64 as modification agents in tailoring the release rate of a molecular indicator species from 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) bilayer-coated superparamagnetic Fe₃O₄/mesoporous silica coreshell nanoparticles. Lastly, we show there is a direct relationship between Pluronic concentration and the indicator molecule release, suggesting Pluronic may be useful for the controlled release of drugs from lipid bilayer-coated carriers.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 1376015

Alternate ID(s):: OSTI ID: 1556668

Report Number(s):: LLNL-JRNL-651806

Journal Information:: Colloids and Surfaces. B, Biointerfaces, Journal Name: Colloids and Surfaces. B, Biointerfaces Journal Issue: C Vol. 122; ISSN 0927-7765

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Inhibition of Growth and Metastasis of Colon Cancer by Delivering 5-Fluorouracil-loaded Pluronic P85 Copolymer Micelles Zhu, Pengxi; Zhao, Naping; Sheng, Dandan Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep20896	journal	February 2016

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Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO–PPO–PEO triblock copolymers [Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO PPO PEO triblock copolymers]

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