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Title: Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO–PPO–PEO triblock copolymers [Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO PPO PEO triblock copolymers]

Journal Article · · Colloids and Surfaces. B, Biointerfaces
ORCiD logo [1];  [1];  [1];  [1];  [1];  [2]; ORCiD logo [1]
  1. Univ. of California, Davis, CA (United States). Dept. of Chemical Engineering and Materials Science
  2. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
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Triblock copolymers comprised of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO, or trade name Pluronic) interact with lipid bilayers to increase their permeability. Here we demonstrate a novel application of Pluronic L61 and L64 as modification agents in tailoring the release rate of a molecular indicator species from 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) bilayer-coated superparamagnetic Fe3O4/mesoporous silica coreshell nanoparticles. Lastly, we show there is a direct relationship between Pluronic concentration and the indicator molecule release, suggesting Pluronic may be useful for the controlled release of drugs from lipid bilayer-coated carriers.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE
Grant/Contract Number:
AC52-07NA27344
OSTI ID:
1376015
Alternate ID(s):
OSTI ID: 1556668
Report Number(s):
LLNL-JRNL-651806
Journal Information:
Colloids and Surfaces. B, Biointerfaces, Vol. 122, Issue C; ISSN 0927-7765
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 16 works
Citation information provided by
Web of Science

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Beyond the lipid-bilayer: interaction of polymers and nanoparticles with membranes journal January 2012
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Cited By (1)

Inhibition of Growth and Metastasis of Colon Cancer by Delivering 5-Fluorouracil-loaded Pluronic P85 Copolymer Micelles journal February 2016

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