U.S. Department of Energy Office of Scientific and Technical Information
Structure of Carbon Nanotube Porins in Lipid Bilayers: An in Situ Small-Angle X-ray Scattering (SAXS) Study [Atomic-level structure of carbon nanotube porins in lipid bilayers: an in-situ small-angle x-ray scattering (SAXS) study]
Carbon nanotube porins (CNTPs), small segments of carbon nanotubes capable of forming defined pores in lipid membranes, are important future components for bionanoelectronic devices as they could provide a robust analog of biological membrane channels. Furthermore, in order to control the incorporation of these CNT channels into lipid bilayers, it is important to understand the structure of the CNTPs before and after insertion into the lipid bilayer as well as the impact of such insertion on the bilayer structure. Here we employed a noninvasive in situ probe, small-angle X-ray scattering, to study the integration of CNT porins into dioleoylphosphatidylcholine bilayers. These results show that CNTPs in solution are stabilized by a monolayer of lipid molecules wrapped around their outer surface. We also demonstrate that insertion of CNTPs into the lipid bilayer results in decreased bilayer thickness with the magnitude of this effect increasing with the concentration of CNTPs.
Tran, Ich C., et al. "Structure of Carbon Nanotube Porins in Lipid Bilayers: An in Situ Small-Angle X-ray Scattering (SAXS) Study [Atomic-level structure of carbon nanotube porins in lipid bilayers: an in-situ small-angle x-ray scattering (SAXS) study]." Nano Letters, vol. 16, no. 7, Jun. 2016. https://doi.org/10.1021/acs.nanolett.6b00466
Tran, Ich C., Tunuguntla, Ramya H., Kim, Kyunghoon, Lee, Jonathan R. I., Willey, Trevor M., Weiss, Thomas M., Noy, Aleksandr, & van Buuren, Tony (2016). Structure of Carbon Nanotube Porins in Lipid Bilayers: An in Situ Small-Angle X-ray Scattering (SAXS) Study [Atomic-level structure of carbon nanotube porins in lipid bilayers: an in-situ small-angle x-ray scattering (SAXS) study]. Nano Letters, 16(7). https://doi.org/10.1021/acs.nanolett.6b00466
Tran, Ich C., Tunuguntla, Ramya H., Kim, Kyunghoon, et al., "Structure of Carbon Nanotube Porins in Lipid Bilayers: An in Situ Small-Angle X-ray Scattering (SAXS) Study [Atomic-level structure of carbon nanotube porins in lipid bilayers: an in-situ small-angle x-ray scattering (SAXS) study]," Nano Letters 16, no. 7 (2016), https://doi.org/10.1021/acs.nanolett.6b00466
@article{osti_1367965,
author = {Tran, Ich C. and Tunuguntla, Ramya H. and Kim, Kyunghoon and Lee, Jonathan R. I. and Willey, Trevor M. and Weiss, Thomas M. and Noy, Aleksandr and van Buuren, Tony},
title = {Structure of Carbon Nanotube Porins in Lipid Bilayers: An in Situ Small-Angle X-ray Scattering (SAXS) Study [Atomic-level structure of carbon nanotube porins in lipid bilayers: an in-situ small-angle x-ray scattering (SAXS) study]},
annote = {Carbon nanotube porins (CNTPs), small segments of carbon nanotubes capable of forming defined pores in lipid membranes, are important future components for bionanoelectronic devices as they could provide a robust analog of biological membrane channels. Furthermore, in order to control the incorporation of these CNT channels into lipid bilayers, it is important to understand the structure of the CNTPs before and after insertion into the lipid bilayer as well as the impact of such insertion on the bilayer structure. Here we employed a noninvasive in situ probe, small-angle X-ray scattering, to study the integration of CNT porins into dioleoylphosphatidylcholine bilayers. These results show that CNTPs in solution are stabilized by a monolayer of lipid molecules wrapped around their outer surface. We also demonstrate that insertion of CNTPs into the lipid bilayer results in decreased bilayer thickness with the magnitude of this effect increasing with the concentration of CNTPs.},
doi = {10.1021/acs.nanolett.6b00466},
url = {https://www.osti.gov/biblio/1367965},
journal = {Nano Letters},
issn = {ISSN 1530-6984},
number = {7},
volume = {16},
place = {United States},
publisher = {American Chemical Society},
year = {2016},
month = {06}}