A SAXS-WAXS study of the endothermic transitions in amorphous or supercooled liquid itraconazole
- Argonne National Lab. (ANL), Argonne, IL (United States); Arizona State Univ., Tempe, AZ (United States)
- Arizona State Univ., Tempe, AZ (United States)
- Univ. of Sheffield, Sheffield (United Kingdom)
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Purdue Univ., West Lafayette, IN (United States)
Small and wide angle high energy x-ray scattering experiments were performed upon cooling itraconazole from the melt to investigate the structural origin of the two transitions at similar to 74 degrees C and similar to 90 degrees C observed in DSC measurements. Slight changes to the main WAXS peak at Q=1.33 +/- 0.01 angstrom(-1) were observed at 90 degrees C and are found to be inter-molecular in nature, suggesting a liquid to isotropic transition. This finding was supported by complementary wide angle neutron scattering measurements. For temperatures at and below similar to 74 degrees C two strong rings appear in the 2D-SAXS pattern at Q= 0.24 +/- 0.01 angstrom(-1) and 0,43 +/- 0.01 angstrom(-1). The SAXS spectra were further deconvoluted into sharp and broad components. A narrowing of the broad component is associated with only minor changes in the packing arrangements of the itraconazole molecules below 90 degrees C, while the appearance of the sharp component below similar to 74 degrees C is attributed to the formation of a polydomain lamellar phase.
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Spallation Neutron Source (SNS); Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- Grant/Contract Number:
- AC05-00OR22725; AC02-06CH11357; AC02-06CH1135
- OSTI ID:
- 1329117
- Alternate ID(s):
- OSTI ID: 1364641; OSTI ID: 1396821
- Journal Information:
- Thermochimica Acta, Vol. 644, Issue C; ISSN 0040-6031
- Publisher:
- ElsevierCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Web of Science
Organic glasses with tunable liquid-crystalline order through kinetic arrest of end-over-end rotation: the case of saperconazole
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journal | January 2020 |
Vapor deposition of a nonmesogen prepares highly structured organic glasses
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journal | September 2019 |
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