Chitosan-Gated Magnetic-Responsive Nanocarrier for Dual-Modal Optical Imaging, Switchable Drug Release, and Synergistic Therapy

Journal Article · Wed Jan 25 04:00:00 EST 2017 · Advanced Healthcare Materials

DOI:https://doi.org/10.1002/adhm.201601080· OSTI ID:1361983

Wang, Hui ^[1]; Mu, Qingxin ^[1]; Revia, Richard ^[1]; Wang, Kui ^[1]; Zhou, Xuezhe ^[1]; Pauzauskie, Peter J. ^[2]; Zhou, Shuiqin ^[3]; Zhang, Miqin ^[1]

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1. Department of Materials Science and Engineering, University of Washington, Seattle WA 98195 USA
2. Department of Materials Science and Engineering, University of Washington, Seattle WA 98195 USA; Fundamental and Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland WA 99354 USA
3. Department of Chemistry, The College of Staten Island, City University of New York, Staten Island NY 10314 USA

In this study, we present a multifunctional yet structurally simple nanocarrier that has a high drug loading capacity, releases drug in response to onset of an AC magnetic field, and can serve as a long-term imaging contrast agent and effectively kills cancer cells by synergistic action. This nanocarrier (HMMC-NC) has a spherical shell structure with a center cavity of 80 nm in diameter. The shell is comprised of two layers: an inner layer of magnetite that exhibits superparamagnetism and an outer layer of mesoporous carbon embedded with carbon dots that exhibit photoluminescence property. Thus in addition to being a drug carrier, HMMC-NC is also a contrast agent for bioimaging. The switchable drug release is enabled by the chitosan molecules attached on the nanocarrier as the switching material which turns on or off the drug release in response to the application or withdrawal of an AC magnetic field.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1361983
• Report Number(s): PNNL-SA--126395
• Journal Information: Advanced Healthcare Materials, Journal Name: Advanced Healthcare Materials Journal Issue: 6 Vol. 6; ISSN 2192-2640
• Publisher: Wiley
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
60 APPLIED LIFE SCIENCES