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An updated radiosynthesis of [18F]AV1451 for tau PET imaging

Journal Article · · EJNMMI Radiopharmacy and Chemistry
Not Available
Research Organization:
Univ. of Michigan, Ann Arbor, MI (United States)
Sponsoring Organization:
USDOE; USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
Grant/Contract Number:
SC0012484
OSTI ID:
1361451
Alternate ID(s):
OSTI ID: 1629770
Journal Information:
EJNMMI Radiopharmacy and Chemistry, Journal Name: EJNMMI Radiopharmacy and Chemistry Journal Issue: 1 Vol. 2; ISSN 2365-421X
Publisher:
Springer Science + Business MediaCopyright Statement
Country of Publication:
Switzerland
Language:
English

References (40)

Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy journal September 2016
Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases journal November 2016
In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum: Tau and Amyloid in AD journal July 2016
A concise radiosynthesis of the tau radiopharmaceutical, [ 18 F]T807 : Radiosynthesis of [ journal July 2013
Synthesis and quality control of [ 18 F]T807 for tau PET imaging : Detailed synthesis and quality control of [18 F]T807 journal July 2016
Increased basal ganglia binding of 18 F-AV-1451 in patients with progressive supranuclear palsy : Tau Pet In PSP and Healthy Elderly journal October 2016
Multimodal evaluation demonstrates in vivo 18F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration journal November 2016
Human Radiation Dosimetry of [18F]AV-1451(T807) to Detect Tau Pathology journal January 2016
Tau imaging: early progress and future directions journal January 2015
Determination of residual Kryptofix 2.2.2 levels in [18F]-labeled radiopharmaceuticals for human use journal December 2007
In vivo tau PET imaging in dementia: Pathophysiology, radiotracer quantification, and a systematic review of clinical findings journal July 2017
Tau pathology in Alzheimer disease and other tauopathies journal January 2005
Fully automated synthesis of [18F]T807, a PET tau tracer for Alzheimer’s disease journal August 2015
[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease journal November 2013
T807, a reported selective tau tracer, binds with nanomolar affinity to monoamine oxidase a journal July 2015
Defining imaging biomarker cut points for brain aging and Alzheimer's disease journal March 2017
Tau protein abnormalities associated with the progression of alzheimer disease type dementia journal January 2007
Electrochemical determination of the pKa of weak acids in N,N-dimethylformamide journal November 1991
Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future journal February 2015
Acidities of carbon and nitrogen acids: the aromaticity of the cyclopentadienyl anion journal January 1981
An Experimental and Theoretical Study on the Prototropic Equilibria of the Four Carboline Isomers journal July 1997
Tau in physiology and pathology journal December 2015
Tau and neurodegenerative disease: the story so far journal December 2015
Green approaches to late-stage fluorination: radiosyntheses of 18 F-labelled radiopharmaceuticals in ethanol and water journal January 2015
356. Diazaindenes (“azaindoles”). Part I. Ionization constants and spectra journal January 1960
Regional profiles of the candidate tau PET ligand 18 F-AV-1451 recapitulate key features of Braak histopathological stages journal March 2016
In vivo imaging of neuromelanin in Parkinson’s disease using 18 F-AV-1451 PET journal May 2016
Tau Positron Emission Tomography Imaging journal December 2016
Biomarkers in dementia: clinical utility and new directions journal September 2014
Novel PET/SPECT Probes for Imaging of Tau in Alzheimer’s Disease journal January 2015
Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer’s Disease journal January 2016
Tau PET imaging: present and future directions journal February 2017
Protein misfolding in neurodegenerative diseases: implications and strategies journal March 2017
In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain journal July 2016
Tau in Alzheimer Disease and Related Tauopathies journal December 2010
Tau as a Therapeutic Target for Alzheimers Disease journal September 2011
Kinetics of the Tau PET Tracer 18F-AV-1451 (T807) in Subjects with Normal Cognitive Function, Mild Cognitive Impairment, and Alzheimer Disease journal May 2016
Modeling Strategies for Quantification of In Vivo 18 F-AV-1451 Binding in Patients with Tau Pathology journal October 2016
Reference Tissue–Based Kinetic Evaluation of 18 F-AV-1451 for Tau Imaging journal September 2016
Kinetic Modeling of the Tau PET Tracer 18 F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects journal December 2016

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