Imaging agents for monitoring changes of dopamine receptors and methods of using thereof

Mukherjee, Jogeshwar; Chandy, George; Milne, Norah; Wang, Ping H.; Easwaramoorthy, Balu; Mantil, Joseph; Garcia, Adriana

Imaging agents for monitoring changes of dopamine receptors and methods of using thereof

Patent · Tue May 30 00:00:00 EDT 2017

OSTI ID:1360974

Mukherjee, Jogeshwar; Chandy, George; Milne, Norah; Wang, Ping H.; Easwaramoorthy, Balu; Mantil, Joseph; Garcia, Adriana

The present invention is related generally to a method for screening subjects to determine those subjects more likely to develop diabetes by quantization of insulin producing cells. The present invention is also related to the diagnosis of diabetes and related to monitor disease progression or treatment efficacy of candidate drugs.

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Research Organization:: The Regents of the University of California, Oakland, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-03ER63598

Assignee:: The Regents of the University of California

Patent Number(s):: 9,662,059

Application Number:: 12/110,135

OSTI ID:: 1360974

Country of Publication:: United States

Language:: English

References (13)

Current Progress in Non-Invasive Imaging of Beta Cell Mass of the Endocrine Pancreas Souza, Fabiola; Freeby, Matthew; Hultman, Kristi Current Medicinal Chemistry, Vol. 13, Issue 23 https://doi.org/10.2174/092986706778521940	journal	October 2006
11C-Fallypride: radiosynthesis and preliminary evaluation of a novel dopamine D2/D3 receptor PET radiotracer in non-human primate brain Mukherjee, Jogeshwar; Shi, Bingzhi; Christian, Bradley T. Bioorganic & Medicinal Chemistry, Vol. 12, Issue 1 https://doi.org/10.1016/j.bmc.2003.10.020	journal	January 2004
¹⁸F-Fallypride PET of Pancreatic Islets: In Vitro and In Vivo Rodent Studies Garcia, A.; Mirbolooki, M. R.; Constantinescu, C. Journal of Nuclear Medicine, Vol. 52, Issue 7, p. 1125-1132 https://doi.org/10.2967/jnumed.111.088583	journal	June 2011
Longitudinal noninvasive PET-based cell mass estimates in a spontaneous diabetes rat model Souza, F. Journal of Clinical Investigation, Vol. 116, Issue 6 https://doi.org/10.1172/JCI27645	journal	June 2006
Preliminary assessment of extrastriatal dopamine d-2 receptor binding in the rodent and nonhuman primate brains using the high affinity radioligand, 18F-fallypride Mukherjee, Jogeshwar; Yang, Zhi-Ying; Brown, Terry Nuclear Medicine and Biology, Vol. 26, Issue 5 https://doi.org/10.1016/S0969-8051(99)00012-8	journal	July 1999
Systematic screening of potential β-cell imaging agents Sweet, Ian R.; Cook, Daniel L.; Lernmark, Åke Biochemical and Biophysical Research Communications, Vol. 314, Issue 4 https://doi.org/10.1016/j.bbrc.2003.12.182	journal	February 2004
Fluorine-18-l-Dihydroxyphenylalanine (18F-DOPA) Positron Emission Tomography as a Tool to Localize an Insulinoma or β-Cell Hyperplasia in Adult Patients Kauhanen, Saila; Seppänen, Marko; Minn, Heikki The Journal of Clinical Endocrinology & Metabolism, Vol. 92, Issue 4 https://doi.org/10.1210/jc.2006-1479	journal	April 2007
Imaging inflammation of the pancreatic islets in type 1 diabetes Denis, M. C.; Mahmood, U.; Benoist, C. Proceedings of the National Academy of Sciences, Vol. 101, Issue 34, p. 12634-12639 https://doi.org/10.1073/pnas.0404307101	journal	August 2004
Dopamine D2-like Receptors Are Expressed in Pancreatic Beta Cells and Mediate Inhibition of Insulin Secretion Rubí, Blanca; Ljubicic, Sanda; Pournourmohammadi, Shirin Journal of Biological Chemistry, Vol. 280, Issue 44, p. 36824-36832 https://doi.org/10.1074/jbc.M505560200	journal	August 2005
Dopaminergic regulation of glucose-induced insulin secretion through dopamine D2 receptors in the pancreatic islets in vitro Shankar, Eswar; Santhosh, K.; Paulose, C. IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), Vol. 58, Issue 3, p. 157-163 https://doi.org/10.1080/15216540600687993	journal	March 2006
Diagnosis and Localization of Focal Congenital Hyperinsulinism by 18F-Fluorodopa PET Scan Hardy, Olga T.; Hernandez-Pampaloni, Miguel; Saffer, Janet R. The Journal of Pediatrics, Vol. 150, Issue 2 https://doi.org/10.1016/j.jpeds.2006.08.028	journal	February 2007
Fluorinated benzamide neuroleptics—III. Development of (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2,3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer Mukherjee, Jogeshwar; Yang, Zhi-Ying; Das, Malay K. Nuclear Medicine and Biology, Vol. 22, Issue 3 https://doi.org/10.1016/0969-8051(94)00117-3	journal	April 1995
Brain imaging of ¹⁸F-fallypride in normal volunteers: Blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors Mukherjee, Jogeshwar; Christian, Bradley T.; Dunigan, Kelly A. Synapse, Vol. 46, Issue 3, p. 170-188 https://doi.org/10.1002/syn.10128	journal	September 2002

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